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CD40LG — IL6

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL6 → CD40LG (increases)
  Evidence: Moreover, exposure of endothelial cells to CD154 strongly up-regulates expression of adhesion molecules (E-selectin, VCAM-1, ICAM-1) [8], chemokines (interleukin [IL]-8, MCP-1) [9], and cytokines (IL-1?, IL-6, IL-12) [10, 11] in these cells, thus potentially fuelling leukocyte recruitment and activation in a major way.
• OpenBEL Selventa BEL large corpus: IL6 → CD40LG (increases)
  Evidence: CD40L induces expression of tumor necrosis factor-a, interferon-g, IL-1, IL-6, and IL-8 in peripheral blood monocytes [71,72]
• OpenBEL Selventa BEL large corpus: IL6 → CD40LG (increases) Lazaar et al., J Immunol 1998*
  Evidence: CD40LT increased TNF alpha induced IL-6 secretion by 26%.

Text-mined interactions from Literome

von Leoprechting et al., Cancer Res 1999 (Melanoma) : CD40 ligation on MM by CD40L transfected murine L-cells or by a soluble CD40L fusion protein up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6 , IL-8, tumor necrosis factor-a, and granulocyte macrophage colony stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB
Kuroiwa et al., J Immunol 1999 (Glomerulonephritis) : Human peripheral blood monocytes, primed with IFN-gamma and GM-CSF, were activated with CD40 ligand (CD40L) or TNF-alpha and cocultured with MC. CD40L activated monocytes induced higher levels of IL-6 , monocyte chemoattractant protein-1 ( MCP-1 ) and ICAM-1 synthesis by MC. Separation of CD40L activated monocytes from MC by a porous membrane decreased the mesangial synthesis of IL-6 by 80 % and ICAM-1 by 45 %, but had no effect on MCP-1
Baccam et al., Eur J Immunol 1999 : Membrane bound CD154 , but not CD40-specific antibody, mediates NF-kappaB independent IL-6 production in B cells
Sugiura et al., J Immunol 2000 (Dermatomyositis...) : Increased CD40 expression on muscle cells of polymyositis and dermatomyositis : role of CD40-CD40 ligand interaction in IL-6 , IL-8, IL-15, and monocyte chemoattractant protein-1 production ... Recombinant human CD40L markedly increased the production of IL-6 , IL-8, IL-15, and monocyte chemoattractant protein-1 of SkMC 2859
Richards et al., Cytokine 2000 : IL-6 had no activity alone, but further enhanced TRAP ( + ) cell formation in mOSM or DEX ( 10 ( -7 ) M ) treated cocultures
Woltman et al., Eur J Immunol 2000 : Furthermore, Dex-DC showed a decreased CD40 ligand induced IL-6 and TNF-alpha production, a complete block in IL-12p40 production, while IL-10 production was unaffected
Bergamini et al., J Infect Dis 2000 (HIV Infections) : ELISA and cytofluorometric analysis demonstrated that CD40L stimulation of HIV-1 infected macrophages resulted in substantial production of IL-1beta and IL-6
Gordon et al., Cell Immunol 2000 : Thrombin and the protease activated receptor (PAR)-1 peptide TRAP ( 14 ) induced these cells to secrete IL-6 in a dose dependent fashion
McDowell et al., Infect Immun 2002 : Leishmania priming of human dendritic cells for CD40 ligand induced interleukin-12p70 secretion is strain and species dependent
Möttönen et al., Arthritis Res 2002 (Arthritis, Rheumatoid) : Regulation of CD154 induced interleukin-12 production in synovial fluid macrophages
Wagner et al., Arterioscler Thromb Vasc Biol 2002 : One consequence of this statin dependent downregulation of CD40 expression was a decrease in CD40 ligand induced endothelial interleukin-12 expression
Dongari-Bagtzoglou et al., Inflamm Res 2003 : Moreover, the data strongly suggest that CD154 induced IL-6 secretion in HUVEC is dependent on COX-2 activity
Jeurissen et al., Eur J Immunol 2004 (Hypergammaglobulinemia) : Furthermore, we showed that caps-PS induce production of IL-4, IL-6 , IL-10, and IFN-gamma, and that this enhanced production was inhibited by blocking the CD40-CD40L interaction
Hubert et al., J Immunol 2004 : CpG ODN and CD40 ligand , but not influenza virus, induced IL-12p40 and IL-6 secretion
Loskog et al., Clin Cancer Res 2005 (Carcinoma...) : CD40L stimulation of dendritic cells induces interleukin-12 expression that drives Th1 type of immune responses with activation of cytotoxic T cells
Zirlik et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis...) : Whereas TRAF-1 deficiency enhanced CD40L induced IL-6 and MCP-1 expression, TRAF-2 and TRAF-5 deficiency inhibited CD40L-inducible IL-6 but not MCP-1 expression ... TRAF-3 silencing in ECs showed increased CD40L induced IL-6 , MCP-1, and IL-8 expression, whereas TRAF-6 silencing increased selectively CD40L induced MCP-1 expression
Bose et al., Hum Immunol 2007 (Carcinoma, Squamous Cell...) : Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L mediated endogenous production of interleukin-12
Sommer et al., Vet Immunol Immunopathol 2009 : In uninfected cells, inhibition of MAPK revealed that CD40L mediated increase in IL-6 gene expression was dependent on activation of ERK1/2, while increases in IL-12p40, iNOS, and IL-10 gene expression were dependent on activation of p38
Missiou et al., Thromb Haemost 2010 (Cardiovascular Diseases...) : Stimulation with recombinant CD40L or membranes over expressing CD40L induced a time- and dose dependent expression of IL-6 , MCP-1, IL-8, and PAI-1
Melchers et al., Retrovirology 2011 : Dendritic cells secreted IL-6 , IL-10 and IL-12 in response to stimulation by SOSIP.R6-IZ-CD40L and were able to activate naïve T cells
Donhauser et al., PloS one 2012 (Chronic Disease...) : In addition, low-dose CD40L contributed to the enhanced production of interleukin 6 and 8 in PBMC of HIV-1 infected donors compared to controls
Urashima et al., Blood 1995 (Leukemia, Plasma Cell...) : CD40 ligand triggered interleukin-6 secretion in multiple myeloma ... These studies support the view that CD40L may trigger IL-6 secretion by both MM cells and BMSCs and that IL-6 mediated autocrine and paracrine growth mechanisms may be possible in MM
Gruss et al., Eur J Immunol 1995 (Hodgkin Disease) : We have found that both the recombinant CD30L and CD40L enhanced interleukin (IL)-6 , TNF and lymphotoxin (LT)-alpha release from cultured H-RS cells
Kennedy et al., Eur J Immunol 1996 : CD40/CD40 ligand interactions are required for T cell dependent production of interleukin-12 by mouse macrophages
Urashima et al., Leuk Res 1996 : Interleukin-10+ CD40L triggered 100-fold increments in IgG, IgA and IgM secretion, but IL-10 suppressed IL-6 secretion triggered with CD40L +/- IL-4
Sempowski et al., J Periodontol 1997 (Gingivitis...) : This CD40/CD40L interaction can stimulate fibroblast activation and synthesis of the proinflammatory cytokine IL-6
Schiller et al., Endocrinology 1997 : IL-6 alone, although bone marrow cells in hormone-free culture produced appreciable amounts of the cytokine, did not induce any TRAP+ MNC