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CD5 — IL6
Text-mined interactions from Literome
Gibson et al., J Mol Cell Immunol 1990
:
Data presented here and elsewhere suggest that this
CD5+ B-cell inducing activity is not
mediated by IL-1, IL-2, IL-3, IL-4, IL-5,
IL-6 , IFN-gamma, GM-CSF, or TNF
Masuda et al., Leuk Res 1991
(Leukemia-Lymphoma, Adult T-Cell) :
However,
CD5+ or CD1+ acute leukemia cells were not
stimulated by IL-3 or
IL-6
Defrance et al., Eur J Immunol 1989
(Leukemia, Lymphocytic, Chronic, B-Cell) :
Recombinant IL 1 alpha, IL 2, IL 3, IL 5,
IL 6 , tumor necrosis factor (TNF)-alpha, IFN-gamma and granulocyte macrophage colony stimulating factor neither inhibit nor
stimulate CD5 expression on B cells, therefore suggesting that the capacity to down-regulate CD5 expression on B cells is specific to IL 4
Kanno et al., Autoimmunity 1993
(Lupus Erythematosus, Systemic) :
However, significant amounts of IgG antibodies were also produced, in the
presence of
IL-6 , by
CD5+Lp-3+sIgM+ , but not by CD5-Lp-3+sIgM+ B cells from 6-month-old mice
Spencer et al., Int Immunol 1997
:
A role for IL-12 in the aging process was suggested when it was found that recombinant IL-12 ( rIL-12 ) directly stimulated splenic CD5+ B cells to secrete IL-10, and both
CD5+ and CD5- B cells could be directly
induced to produce
IL-6 in response to rIL-12