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CD72 — EPHB2

Text-mined interactions from Literome

Adachi et al., J Immunol 2000 (Calcium Signaling...) : In this paper we demonstrate that expression of CD72 down-modulates both extracellular signal related kinase ( ERK ) activation and Ca2+ mobilization induced by BCR ligation in the mouse B lymphoma line K46micromlambda, whereas BCR mediated ERK activation was not reduced by the ITIM mutated form of CD72
Wu et al., J Immunol 2001 (Severe Combined Immunodeficiency) : Although both CD72 and BCR induced Btk dependent ERK activation, CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR, as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP, agents that inhibit ERK activity
Li et al., J Immunol 2006 : CD72 ligation with anti-CD72 Ab ( K10.6 ), which mimics the binding of CD100 ( a natural ligand for CD72 ) to release the inhibitory function of CD72, augments cell proliferation, Ca ( 2+ ) flux, IkappaBalpha activation, and ERK MAPK activity upon Ag stimulation in wild-type B cells