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APP — CDK5
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CDK5
—
APP
(direct interaction, pull down)
Oláh et al., J Biol Chem 2011
-
IRef Hprd Interaction:
APP
—
CDK5
(in vitro)
Iijima et al., J Neurochem 2000*, Taru et al., FEBS Lett 2004*, Aplin et al., J Neurochem 1996*
-
IRef Hprd Interaction:
APP
—
CDK5
(in vivo)
Iijima et al., J Neurochem 2000*, Taru et al., FEBS Lett 2004*, Aplin et al., J Neurochem 1996*
Text-mined interactions from Literome
Liu et al., FEBS Lett 2003
(Neuroblastoma) :
These results confirm the involvement of Cdk5 in APP processing, and suggest that p35- and p25 mediated
Cdk5 activities
lead to discrete
APP phosphorylation
Ryder et al., Biochem Biophys Res Commun 2003
(Alzheimer Disease) :
Neither GSK3 nor
CDK5 inhibition by these means significantly
affected cellular
APP levels or APP maturation
Cole et al., J Biol Chem 2008
:
The increased phosphorylation in
Alzheimer disease could be
due to increases in
Cdk5 and/or GSK3 activity or, alternatively, through decreased activity of a CRMP phosphatase