Gene interactions and pathways from curated databases and text-mining

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CA2 — CDKN1A

Text-mined interactions from Literome

Sakaguchi et al., J Cell Biol 2003 (Calcium Signaling) : Introduction of anti-S100C/A11 antibody into the cells largely abolished the growth inhibition induced by Ca2+ and the induction of p21CIP1/WAF1
King et al., Carcinogenesis 2006 (Carcinoma, Squamous Cell...) : The DeltaN-terminus is sufficient to maintain keratinocytes in a proliferative state, as both DeltaN forms block Ca2+ mediated p21WAF1 induction and S-phase arrest, while sustaining elevated PCNA levels
Todd et al., Am J Pathol 1998 : Induction of p21WAF1 by phorbol ester and Ca2+ was inhibited by the specific protein kinase C inhibitor Ro 31-8220 ... The results demonstrate a differential time course of p21WAF1 protein up-regulation in response to phorbol ester and Ca2+ , signals that result in keratinocyte differentiation, and suggest that induction of p21WAF1 in differentiating human keratinocytes occurs through protein kinase C-dependent and p53 independent mechanisms