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CA2 — CDKN1A
Text-mined interactions from Literome
Sakaguchi et al., J Cell Biol 2003
(Calcium Signaling) :
Introduction of anti-S100C/A11 antibody into the cells largely abolished the growth inhibition
induced by
Ca2+ and the induction of
p21CIP1/WAF1
King et al., Carcinogenesis 2006
(Carcinoma, Squamous Cell...) :
The DeltaN-terminus is sufficient to maintain keratinocytes in a proliferative state, as both DeltaN forms block
Ca2+ mediated
p21WAF1 induction and S-phase arrest, while sustaining elevated PCNA levels
Todd et al., Am J Pathol 1998
:
Induction of
p21WAF1 by phorbol ester and
Ca2+ was inhibited by the specific protein kinase C inhibitor Ro 31-8220 ... The results demonstrate a differential time course of
p21WAF1 protein up-regulation in
response to phorbol ester and
Ca2+ , signals that result in keratinocyte differentiation, and suggest that induction of p21WAF1 in differentiating human keratinocytes occurs through protein kinase C-dependent and p53 independent mechanisms