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CDKN1B — NOTCH4

Text-mined interactions from Literome

Dohda et al., Exp Cell Res 2007 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : This suggests that other immediate Notch downstream genes are activated, and we found that Notch signaling controls the levels of expression of the E3 ubiquitin ligase SKP2 and its target protein p27Kip1 ... Collectively, our data suggest that the aberrantly high Notch signaling in T-ALL maintains SKP2 at a high level and reduces p27Kip1 , leading to more rapid cell cycle progression
Heo et al., Growth Factors 2008 : Moreover, TGF-alpha increased cyclin D/CDK 4 and cyclin E/CDK 2 levels, while decreasing p21cip1/waf1 and p27kip1 , which were blocked by the inhibition of Akt, mTOR and Notch