Gene interactions and pathways from curated databases and text-mining

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CHKA — PPP2R1A

Text-mined interactions from Literome

Li et al., J Biol Chem 2007 : Claspin may then be one of the phosphoproteins through which PP2A ( Aalpha/Cbeta ) affects Chk1 phosphorylation when ATR is activated by human immunodeficiency virus-1 Vpr
Freeman et al., Cell cycle (Georgetown, Tex.) 2010 : PP 2A negatively regulates CHK2 phosphorylation at multiple sites, as well as its kinase activity
Parsels et al., Clin Cancer Res 2011 (Pancreatic Neoplasms) : pS345 Chk1 induction in response to gemcitabine and AZD7762 occurred in the presence of PP2A inhibition and in association with elevated ?H2AX, suggesting that DNA damage is an underlying mechanism