Gene interactions and pathways from curated databases and text-mining

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AKT1 — CNR1

Text-mined interactions from Literome

Samson et al., J Immunol 2003 : CB1 inhibition does not affect AKT or extracellular signal regulated kinase activation by cannabinoids, indicating that CB2 is the predominant regulatory receptor for these kinases in this cell context
Catani et al., Cell Mol Life Sci 2010 : Anandamide extends platelets survival through CB(1) dependent Akt signaling ... Instead, AEA binding to type-1 cannabinoid receptor activates Akt , which regulates, through phosphorylation of Bad, the interactions among different Bcl-2 family members
Preet et al., Cancer prevention research (Philadelphia, Pa.) 2011 (Carcinoma, Non-Small-Cell Lung...) : Upon further elucidation into the molecular mechanism, we observed that both CB1 and CB2 agonists inhibited phosphorylation of AKT , a key signaling molecule controlling cell survival, migration, and apoptosis, and reduced matrix metalloproteinase 9 expression and activity
Wu et al., Bone 2011 : CB1 signaling regulated JNK, ERK, GSK-3ß, and Akt activation as well as Runx2 and IGF-I expression