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AKT1 — CNTN1

Text-mined interactions from Literome

Hung et al., Chem Biol Interact 2009 (Lung Neoplasms...) : However, only ERK signaling pathway inhibitor PD98059, but not AKT signaling pathway inhibitor LY294002, suppressed the induction of contactin-1 by NNK
Yan et al., PloS one 2013 : In an effort to investigate the mechanisms whereby contactin-1 reduces E-cadherin expression, we observed that contactin-1 plays a role in AKT activation, as knockdown of contactin-1 attenuated AKT activation ... Upon overexpression, CNTN-1 reduced E-cadherin levels in one cell line and increased AKT activation in the other ... These observations thus suggest that contactin-1 enhances AKT activation in part by preventing PHLPP2 mediated AKT dephosphrorylation