Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Basbous et al., J Biol Chem 2003 : Our results support the hypothesis that HBZ could be a negative modulator of the Tax effect by controlling Tax expression at the transcriptional level and by attenuating activation of AP-1 by Tax
Mori et al., J Virol 2004 (Disease Models, Animal...) : Although the viral protein Tax is an activator of NF-kappaB and AP-1 , FR901228 induced apoptosis was not associated with reduced expression of Tax
Tomita et al., Leuk Res 2006 (Leukemia-Lymphoma, Adult T-Cell) : Curcumin also inhibited HTLV-1 Tax induced AP-1 transcriptional activity
Peloponese et al., J Biol Chem 2006 (Cell Transformation, Viral) : We show here that Tax , in the absence of NF-kappaB signaling, can activate activator protein-1 to promote cellular proliferation and survival ... Tax is shown to activate activator protein-1 through the phosphatidylinositol 3-kinase/Akt pathway
Marban et al., Retrovirology 2012 : In addition, when Tax2 and APH-2 are co-expressed, they physically interact in vivo and in vitro and APH-2 acts as an inhibitor of Tax2 mediated activation of AP-1 transcription
Armstrong et al., Proc Natl Acad Sci U S A 1993 : In this report, we demonstrate that Tax also enhances the site-specific DNA binding activity of serum response factor and Fos-Jun and modestly enhances the binding of the NF-kappa B subunits, p50 and p65