Gene interactions and pathways from curated databases and text-mining

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COQ6 — IL6

Text-mined interactions from Literome

Inui et al., Biofactors 2008 : Our in vitro studies showed that UVB induced IL-6 production of normal human keratinocyte ( NHKC ) decreased in the presence of CoQ10 ... Taken together, our results indicate that CoQ10 may inhibit the production of IL-6 which stimulate fibroblasts in dermis by paracrine manner to up-regulate MMPs production, and contribute to protecting dermal fiber components from degradation, leading to rejuvenation of wrinkled skin
Bessler et al., J Nutr Sci Vitaminol (Tokyo) 2010 : The production of the proinflammatory cytokines IL-1beta, IL-6 and IFNgamma and that of the anti-inflammatory cytokines IL-1ra and IL-10 by PBMC was not affected by CoQ10 , whereas TNFalpha secretion was significantly decreased when the cells were incubated with 0.6 and 1.25 muM of CoQ10