Gene interactions and pathways from curated databases and text-mining

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CA2 — CPA1

Text-mined interactions from Literome

Rahmani et al., Frontiers in bioscience : a journal and virtual library 1999 : The internal stores of Ca2+ were depleted by repeated alpha 1-adrenergic stimulation with phenylephrine ( PE ) and refilling of these stores was prevented by cyclopiazonic acid (CPA) and/or thapsigargin ( TG ), two known inhibitors of Ca2+ATPase , the enzyme that drives sarcoplasmic calcium pumps
Toms et al., Neuropharmacology 1999 : However, in the presence of 1 microM DHPG, CPA potently ( EC50 = 12.3 +/- 1.9 nM ) increased [ Ca2+ ] i responses
Sekiguchi et al., Br J Pharmacol 1999 (Body Weight...) : 1. The effects of cyclopiazonic acid (CPA) , a selective inhibitor of sarcoplasmic reticulum ( SR ) Ca2+-ATPase , on twitch contraction and on the resting state of tension and intracellular Ca2+ level ( [ Ca2+ ] i ) of the oesophageal striated muscle of stroke-prone spontaneously hypertensive rats ( SHRSP ) and normotensive Wistar Kyoto rats ( WKY ) were compared
Ishii et al., Jpn J Pharmacol 1992 : These results suggest that CPA inhibits the intracellular Ca2+ release, probably due to the depletion of Ca2+ stores induced by inhibition of the ATP dependent Ca2+ pump
Uyama et al., Br J Pharmacol 1992 : These results suggest that CPA selectively inhibits ATP dependent Ca2 '' -uptake into intracellular storage sites in skinned ileal smooth muscle strips
Matsumoto et al., J Oral Sci 2003 : The effect of cyclopiazonic acid (CPA) on changes in the intracellular free Ca2+ concentration ([Ca2+]i) evoked by bradykinin ( BK ), histamine ( HIST ) and thapsigargin ( TG ) was investigated in human gingival fibroblasts ... CPA itself dose-dependently stimulated [Ca2+ ] i responses in both the absence and presence of extracellular Ca2+
Martínez-Azorín et al., FEBS Lett 2004 : The experimental data suggest that in the presence of CPA , only a single Ca2+ ion binds to the Ca2+-ATPase
Wang et al., Biochem Pharmacol 2004 (Calcium Signaling) : In the presence of external Ca2+, pretreatment of neutrophils with 3- ( 5'-hydroxymethyl-2'-furyl ) -1-benzyl indazole ( YC-1 ) inhibited the cyclopiazonic acid (CPA) induced [Ca2+ ] ( i ) elevation in a concentration- but not a time dependent manner, while YC-1 had no effect on the Ca2+ signals in a Ca2+-free medium
Kahlert et al., J Neurosci Res 2005 : Astrocytes displayed a large CPA mediated Ca2 response, indicating a high level of Ca2+ load in the stores in astrocytes
Hsu et al., Biochem Pharmacol 2005 (Calcium Signaling) : In this study, we demonstrate that N-ethylmaleimide ( NEM ), a cell permeable thiol alkylating agent, enhanced the [Ca2+ ] i rise caused by stimulation with cyclopiazonic acid (CPA) , a sarcoplasmic-endoplasmic reticulum Ca2+-ATPase inhibitor , in rat neutrophils ... In the absence of external Ca2+, NEM rendered the CPA induced [Ca2+ ] i elevation persistently but inhibited the fMLP induced Ca2+ spike, which was reversed by tris- ( 2-cyanoethyl ) phosphine ( TCP ), a cell permeable reductant without a thiol group
Rubini et al., J Cell Physiol 2006 (Calcium Signaling) : ATP caused an increase of [Ca2+ ] i by a mechanism only partly dependent on external Ca2+ ; the residual ATP effect was blocked by cyclopiazonic acid (CPA) and was therefore due to the release of Ca2+ from its intracellular pools ... CPA caused an early [Ca2+ ] i response due to release from intracellular storage sites, followed by a late [Ca2+ ] i response due to the influx of this cation from the extracellular space, probably triggered by the opening of store operated channels (SOCs) in the plasma membrane
Stankevicius et al., Br J Pharmacol 2006 : Incubation with apamin and charybdotoxin did not change acetylcholine or CPA induced increases in [Ca2+ ] i, but inhibited the sustained NO release induced by CPA
Resnik et al., Am J Physiol Lung Cell Mol Physiol 2007 (Calcium Signaling...) : Under both hypoxic and normoxic conditions, cyclopiazonic acid (CPA) increased [Ca2+ ] i more in PHTN than in control PA SMC
Liu et al., Biochemistry 2009 : The fungal neurotoxin alpha-cyclopiazonic acid (CPA) , a nanomolar inhibitor of Ca2+-ATPase , has a pentacyclic indole tetramic acid scaffold that arises from one molecule of tryptophan, acetyl-CoA, malonyl-CoA, and dimethylallyl pyrophosphate by consecutive action of three enzymes, CpaS, CpaD, and CpaO
Seidler et al., J Biol Chem 1989 : The effect of CPA on the sarcoplasmic reticulum Ca2+-ATPase appears to be fairly specific, since the kidney and brain Na+, K+-ATPase ( EC 3.6.1.37 ), the gastric H+, K+-ATPase ( EC 3.6.1.36 ), the mitochondrial F1-ATPase ( EC 3.6.1.34 ), the Ca2+-ATPase of erythrocytes, and the Mg2+ activated ATPase of T-tubules and surface membranes of rat skeletal muscle were not inhibited by CPA, even at concentrations as high as 1000 nmol/mg protein
Lien et al., Am J Physiol 1995 : Without glucose, 1 microM TG induced a sustained elevation in [ Ca2+ ] i, which increased further with glucose addition, whereas 15 microM CPA induced a transient increase in [ Ca2+ ] i that was not affected by further addition of glucose
Wang et al., Br J Pharmacol 1994 : Cyclopiazonic acid (CPA) induced the release of Ca2+ from intracellular stores and this was also reduced by gomisin C
Kasai et al., Br J Pharmacol 1994 : CPA inhibited oxytocin induced Ca2+ release and contraction, the half and full inhibitory concentrations of CPA being 0.3 and 10 microM, respectively
Omote et al., Acta Physiol Scand 1993 : Ryanodine and CPA inhibited both phenylephrine induced Ca2+ release from the SR and Ca2+ sequestration, without affecting Ca2+ influx across the plasmalemma, evaluated by monitoring agonist induced contractions
Uyama et al., Br J Pharmacol 1993 : 6. These results indicate that CPA enhances ileal smooth muscle excitability and increases Ca2+-influx through voltage dependent Ca2+ channels ... The effect may be consistent with the hypothesis that CPA induced decrease in stored Ca due to Ca-pump inhibition reduces the Ca2+ dependent K+ current and indirectly enhances Ca2+-influx through membrane activity resulting from the increased excitability.Direct evidence for the regulation of Ca2+ channel activity by intracellular Ca storage sites was not obtained in the present study
Dickenson et al., Br J Pharmacol 1993 : 3. Removal of extracellular Ca2+ ( experiments performed in Ca ( 2+ ) -free buffer containing 0.1 mM EGTA ) had no effect on the synergistic interaction between CPA ( 300 nM ) and histamine ( 1 microM )
Li et al., Cell Growth Differ 1995 : In the absence of extracellular Ca2+ , both Tg and CPA transiently increase Cai and deplete intracellular Ca2+ stores ; while in the presence of extracellular Ca2+, Tg and CPA stimulate Ca2+ influx and cause a sustained increase in Cai while depleting stored Ca2+
Casavola et al., J Membr Biol 1996 : CPA , added to cells in suspension, caused a rapid rise in [Ca2+ ] i that was antagonized by CPX, not affected by CSC and prevented by thapsigargin preincubation
Golovina et al., Glia 1996 : In the absence of extracellular Ca2+, cyclopiazonic acid (CPA) , an inhibitor of the endoplasmic reticulum ( ER ) Ca ( 2+ ) -ATPase, induced a transient, four-fold increase in [ Ca2+ ] cyt due to the release of Ca2+ from inositol triphosphate ( IP3 ) sensitive stores
Higuchi et al., Am J Physiol 1996 : CPA induces a sustained increase in [Ca2+ ] i of endothelial cells in situ and relaxes porcine coronary artery ... Using fura 2 fluorometry, we investigated the effect of cyclopiazonic acid (CPA) , an inhibitor of Ca2+ pump adenosinetriphosphatase of the endoplasmic reticulum, on cystosolic Ca2+ concentration ([Ca2+]i) and tension in porcine aortic valvular endothelial cells and coronary arterial strips with endothelium ... These results indicate that the CPA induced increase in [ Ca2+ ] i depends on the Ca2+ release and the Ca2+ influx in the endothelial cells in situ and that the CPA induced endothelium dependent decreases in [ Ca2+ ] i and tension in the smooth muscle are due to the combined effect of N omega-nitro-L-arginine-sensitive and -resistant factors
Sekiguchi et al., Br J Pharmacol 1996 : 1. The effects of cyclopiazonic acid (CPA) and thapsigargin ( TG ), both of which are known to inhibit sarcoplasmic reticular Ca ( 2+ ) -ATPase, on the mechanical activities, intracellular Ca2+ level and electrical activities of smooth muscle of the carotid artery of stroke-prone spontaneously hypertensive rats ( SHRSP ) and Wistar Kyoto rats ( WKY ) were compared
Yoshikawa et al., Am J Physiol 1996 : The effects of cyclopiazonic acid (CPA) , an inhibitor of the sarco ( endo ) plasmic reticulum Ca ( 2+ ) -ATPase ( SERCA ), on cytosolic Ca2+ concentration ([Ca2+]c) and membrane currents were studied in isolated urinary bladder myocytes to test the hypothesis that the sarcoplasmic reticulum ( SR ) buffers Ca2+, which enters the myocyte at a slow to moderate rate ... In 12 of these 40 cells, CPA increased [ Ca2+ ] c and IK, Ca signals
Petkov et al., Pflugers Arch 1996 : Cyclopiazonic acid (CPA) , a specific inhibitor of SR Ca2+-ATPase , caused a significant and sustained increase in muscle tone, depending on the presence of extracellular Ca2+
Yuan et al., Am J Physiol 1997 : Authentic NO ( approximately 0.3 microM ) reversibly diminished 5-HT induced [ Ca2+ ] i transients but augmented CPA induced Ca2+ release in the absence of extracellular Ca2+
Bambrick et al., Glia 1997 (Alzheimer Disease...) : In the absence of extracellular Ca2+, CPA induced a transient increase in [Ca2+ ] cyt to over 1200 nM in Ts16 astrocytes as compared to only 500 nM in euploid cells, indicating an increased amount of Ca2+ in the Ts16 astrocyte ER
Morgan et al., J Physiol 1997 : A slow decline of tension was produced by cyclopiazonic acid (CPA) , a sarcoplasmic reticulum Ca2+ uptake pump inhibitor
Nomura et al., Br J Pharmacol 1997 (Hypertension) : Differences in the effects of cyclopiazonic acid (CPA) and thapsigargin, agents which inhibit the Ca ( 2+ ) -ATPase of SR, on tension and cellular Ca2+ level were assessed in endothelium denuded strips of femoral arteries from 13-week-old SHR and normotensive Wistar-Kyoto rats ( WKY )
Tostes et al., Braz J Med Biol Res 1997 (Hypertension) : We tested the hypothesis that cyclopiazonic acid (CPA) , an inhibitor of the sarcoplasmic reticulum ( SR ) Ca ( 2+ ) -ATPase, increases intracellular Ca2+ concentration ([Ca2+]) in aortic myocytes and that the increase in [Ca2+ ] i is higher in aortic cells from deoxycorticosterone acetate ( DOCA ) -hypertensive rats ... The effects of CPA on resting [ Ca2+ ] i and on caffeine induced increase in [ Ca2+ ] i after [ Ca2+ ] i depletion and reloading were compared in aortic cells from DOCA and normotensive rats ... CPA induced increase in [ Ca2+ ] i did not occur in the absence of extracellular Ca2+ or in the presence of nifedipine
Sasajima et al., Biochem Biophys Res Commun 1997 : We investigated the effects of 10 microM cyclopiazonic acid (CPA) , 10 microM ryanodine, and 10 mM caffeine on the rate of Ca2+ depletion from the ER and on Ca2+ and Mn2+ influx using fura-2 fluorescence
Claflin et al., J Physiol 1998 : Tension and [Ca2+ ] i were recorded during the slow decline of tension following stimulation in the presence of cyclopiazonic acid (CPA) , a sarcoplasmic reticulum Ca2+-uptake pump inhibitor
Takahashi et al., Gen Pharmacol 1998 : 1. We examined the effects of ryanodine and cyclopiazonic acid (CPA) on Ca2+ release from myocardial sarcoplasmic reticulum ( SR ) with skinned fibers of neonatal rat ventricular myocardium ... These results suggest that ryanodine and CPA inhibit Ca2+ release from the SR and Ca2+ uptake into it in neonatal myocardia
Duke et al., Pflugers Arch 1998 : At a bathing [Ca2+ ] of 100 nM, introduction of 20 microM CPA induced a slow release of Ca2+ from the SR
Asano et al., Eur J Pharmacol 1998 : To clarify whether sarcoplasmic reticulum of the cerebral arteries can buffer the sustained Ca2+ influx, effects of cyclopiazonic acid (CPA) , an inhibitor of sarcoplasmic reticulum Ca2+-ATPase , were determined in endothelium denuded strips of the cerebral ( basilar, posterior communicating, middle cerebral ), mesenteric and coronary arteries of the dog
Wardle et al., Am J Physiol 1998 : We tested this hypothesis by eliciting responses of `` desensitized PCASM '' to 40 mM KCl in the presence of cyclopiazonic acid (CPA) , an SR Ca2+-ATPase inhibitor
Srinivas et al., Curr Eye Res 1998 : UTP and msATP stimulated Mn2+ influx following [Ca2+ ] i peak similar to that observed in response to cyclopiazonic acid (CPA) , an inhibitor of ER Ca2+-ATPase