◀ Back to EPHB2

CREB1 — EPHB2

Text-mined interactions from Literome

Schwarzschild et al., J Neurochem 1999 : In primary cultures of striatal neurons, glutamatergic activation of ERK and one of its transcription factor targets, CREB , showed a calcium dependence typical of NMDA receptor mediated responses
Grewal et al., J Biol Chem 2001 : This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and ERK and activation of cAMP-responsive element binding protein ( CREB ), NF-kappaB, and E2F ), as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs
Tokunou et al., Arterioscler Thromb Vasc Biol 2001 : These results suggest that the CRE site and CREB play an important role in thrombin induced IL-6 gene expression in VSMCs. Transactivation of EGF-R and activation of ERK and p38 MAPK are involved in this process
Tada et al., J Invest Dermatol 2002 : The mitogen induced phosphorylation of p90rsk and CREB was dependent on ERK1/2 activation, and was mediated by intracellular calcium mobilization and by protein kinase C and tyrosine kinase activation, but not by activation of the cAMP dependent protein kinase A. Exposure of melanocytes to ultraviolet radiation B resulted in the phosphorylation of the stress induced mitogen- activated protein kinases p38 and JNK/SAPK, but not ERK1/2
Funakoshi et al., J Biol Chem 2002 : Inhibition of epidermal growth factor-receptor by AG1478 suppressed the AngII induced CREB phosphorylation as well as activation of ERK and p38MAPK
Koncz et al., Immunol Lett 2002 : We compared the BCR induced intracellular [ Ca2+ ] transient, protein tyrosine phosphorylation and ERK phosphorylation, furthermore, the activation of Elk-1 and CREB transcription factors
Huttunen et al., J Biol Chem 2002 (Neuroblastoma) : Furthermore, inhibition of ERK1/2-Rsk2 dependent CREB phosphorylation efficiently inhibited up-regulation of chromogranin gene expression upon RAGE activation
Zhou et al., Biochem Biophys Res Commun 2002 : CREB DNA binding activation by a 50-Hz magnetic field in HL60 cells is dependent on extra- and intracellular Ca ( 2+ ) but not PKA, PKC, ERK , or p38 MAPK ... Furthermore, We found that the MF-induced increase of CREB DNA binding in HL60 cells was dependent on both extracellular and intracellular Ca ( 2+ ) but not PKA, PKC, ERK , or p38 MAPK by using various pathway inhibitors
Carrasco et al., Am J Physiol Cell Physiol 2003 : Both early gene activation and CREB phosphorylation were inhibited by ERK phosphorylation blockade
Alonso et al., Cell Mol Neurobiol 2002 (MAP Kinase Signaling System) : Inhibition of ERK1/2 activation by PD098059 produced similar effects and also reduced CREB phosphorylation
Qiao et al., Mol Cell Biol 2003 : DCA induced ERK1/2 activation was responsible for increased DNA binding of C/EBPbeta, CREB , and c-Jun/AP-1
Lee et al., Biochem Biophys Res Commun 2003 (MAP Kinase Signaling System) : Inhibition of ERK1/2 with PD98059 and of p38 MAPK with SB203580 efficiently blocked LPA mediated phosphorylation of CREB
Jüttner et al., Cell Microbiol 2003 (Helicobacter Infections...) : Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription : critical importance of MEK/ERK dependent activation of USF1/-2 and CREB transcription factors
Dalle et al., J Biol Chem 2004 : Remarkably, glucagon promotes the nuclear translocation of ERK1/2 and induces the phosphorylation of cAMP-response element binding protein ( CREB )
Nishihara et al., J Biol Chem 2004 (Colonic Neoplasms) : Studies with pharmacological inhibitors revealed that cAMP dependent phosphorylation of CREB required activation of ERK1/2 and p38 MAPK but was largely independent of protein kinase A. Immunoblots and transcriptional reporter assays using specific inhibitors, as well as expression of constitutively active forms of MEK1 and MKK3, showed that c-IAP2 induction by cAMP is regulated predominantly through ERK1/2 and p38 MAPK and suggested involvement of p90 ribosomal protein S6 kinase and mitogen and stress response kinase-1 as well
Grady et al., J Immunol 2004 (MAP Kinase Signaling System) : We also show that CREB is activated downstream of the pre-TCR complex, and that the induction of CREB activity is regulated by protein kinase C alpha- and ERK-MAPK mediated signals
Inoue et al., J Biol Chem 2004 : DNA precipitation assays and DNA decoy experiments indicated that ERK dependent activation of CREB binding to a CRE/AP-1 like element ( designated `` CRE2 '' ) at the position of -413 largely contributed to the transcriptional effects of FSS
Suzuki et al., J Comp Neurol 2004 (Synaptic Transmission) : Second, while phosphorylation of ERK and RSK are modulated by visual experience, phosphorylation of CREB at serines 133, 142, or 143 is detected constitutively and is unaffected by experience
Carrasco et al., Biol Res 2004 (Calcium Signaling) : We present novel results from our laboratory showing ERK mediated CREB activation by hydrogen peroxide
Barlow et al., Am J Respir Cell Mol Biol 2006 : Oxidant stress mediated regulation of extracellular signal regulated kinases ( ERK1/2 ) is linked to pathologic outcomes in lung epithelium, yet a role for Ca2+ and Ca2+/cAMP-response element binding protein ( CREB ) in ERK1/2 signaling has not been defined ... In this study, we tested the hypotheses that oxidants induce Ca2+ mediated phosphorylation of ERK and CREB, and that CREB is required for oxidant induced proliferation and apoptosis
Arany et al., Kidney Int 2005 : Inhibition of ERK also inhibited CREB activation
Maldonado et al., Biochem Biophys Res Commun 2005 (Calcium Signaling) : IGF-1 induced CREB phosphorylation was mediated by MEK1/ERK , PI3-K, p38-MAPK, as well as Ca ( 2+ ) /calmodulin kinase and calcineurin
Mattson et al., J Neurochem 2005 (Cocaine-Related Disorders) : Therefore, enhanced activation of ERK , but not PKA, enables and mediates cocaine induced CREB phosphorylation in nucleus accumbens of rats that are sensitized by repeated cocaine administration outside their home cages
Cao et al., Pain 2005 (MAP Kinase Signaling System...) : The spinal ERK inhibition or knockdown also reduced morphine withdrawal induced phosphorylation of cAMP response element binding protein ( CREB ), which is one of the important downstream substrates of ERK pathway, and Fos expression
Sharma et al., Mol Cell Endocrinol 2005 : PD98059 did not block activation of ERK5 and MEF2C, but inhibited CREB phosphorylation by 90 %
Mathieson et al., Br J Pharmacol 2006 : S1P induced CREB activation was dependent on ERK1/2 and Ca2+-calmodulin dependent protein kinase ( CaMK ) activation ... CREB activation by SPC required both p38MAPK and CaMK activation, but not ERK1/2
Gelain et al., Cell Signal 2006 : Retinol induces the ERK1/2 dependent phosphorylation of CREB through a pathway involving the generation of reactive oxygen species in cultured Sertoli cells
Park et al., Neurosci Lett 2006 (Neuroblastoma) : The mitogen activated protein kinase/extracellular signal regulated kinase ( MAPK/ERK ) activates a transcription factor CREB ... Previously, we reported that N-acetyl-O-methyldopamine ( NAMDA ) protects neurons from ischemia via enhancing ERK dependent CREB phosphorylation ... The effect was completely blocked by a specific MEK inhibitor U0126, suggesting the involvement of ERK dependent CREB signaling
Shah et al., Brain Res 2006 : Short chain fatty acids induce TH gene expression via ERK dependent phosphorylation of CREB protein
Xin et al., J Neurosci Res 2006 : Western blotting analysis showed that the protein level of phosphorylated ERK ( p-ERK ) in ipsilateral spinal dorsal horn was transiently increased after LTP induction, starting at 15 min and returning to control at 60 min after tetanic stimulation and that the protein level of p-CREB increased at 30 min, persisting for at least 3 hr after LTP induction
Sun et al., Genes Cells 2006 : Taken together, NGF induced PC12 cell differentiation requires M-Ras-ERK pathway mediated activation of CREB
Li et al., Biochem Biophys Res Commun 2006 : Inhibition of ERK1/2 with PD98059 ( 10 ( -5 ) M ) completely inhibited the activation of p90 ( RSK ), but did not block CREB-S133 phosphorylation in TPA perfused heart, indicating that PKA, CaMKII, and p90 ( RSK ) do not phosphorylate CREB-S133 in the murine heart
Maher et al., Proc Natl Acad Sci U S A 2006 (MAP Kinase Signaling System) : Here we show that the flavonoid fisetin activates ERK and induces cAMP response element binding protein ( CREB ) phosphorylation in rat hippocampal slices, facilitates long-term potentiation in rat hippocampal slices, and enhances object recognition in mice
Kemmerling et al., Cell Calcium 2007 (Calcium Signaling) : We propose that ryanodine receptor stimulation by activity generated redox species produces calcium release signals that may contribute significantly to hippocampal synaptic plasticity, including plasticity that requires long lasting ERK dependent CREB phosphorylation
Adiseshaiah et al., J Immunol 2006 (MAP Kinase Signaling System) : ERK inhibition not only blocked phosphorylation of Elk1, CREB , and ATF1, which constitutively bind to the FRA-1 promoter, but also suppressed the recruitment of c-Jun to the promoter ... Our findings collectively indicate that ERK signaling plays key roles in both Elk1, CREB , and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in response to TNF-alpha in pulmonary epithelial cells
Ronda et al., J Steroid Biochem Mol Biol 2007 : 1alpha,25 ( OH ) ( 2 ) D ( 3 ) and 17beta-estradiol also induced the phosphorylation of CREB and Elk-1 transcription factors in an ERK1/2 dependent manner
Lopez-Bergami et al., Cancer Cell 2007 (MAP Kinase Signaling System...) : Constitutively active ERK increases c-Jun transcription and stability, which are mediated by CREB and GSK3, respectively
Tu et al., Cell Signal 2007 : Moreover, both baclofen and CGP7930 induce ERK dependent CREB phosphorylation
Martorell et al., Journal of thrombosis and haemostasis : JTH 2007 : NOR-1 up-regulation by thrombin is dependent on multiple pathways, including cytosolic Ca ( 2+ ), activation of protein kinase C ( PKC ), mitogen activated protein kinase ( MAPK ) pathways [ both extracellular regulated kinase (ERK) and p38 MAPK ], and downstream activation of cAMP response element binding protein ( CREB )
Song et al., Gut 2007 (Adenocarcinoma...) : Unconjugated bile acids induce CREB and AP-1 dependent COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of PI3K/AKT and ERK1/2
Chen et al., J Neurophysiol 2007 : PREGS also triggered a persistent phosphorylation of extracellular signal regulated kinase 2 ( ERK2 ) followed by an ERK dependent phosphorylation of cAMP-response element binding protein ( CREB ), which was crucial for the LTP PREGS induction and was sensitive to ifenprodil
Wei et al., Biochem Pharmacol 2007 (Adenocarcinoma...) : Activation of ERK and p38 MAPK appeared to be mediated primarily by transactivation of EGFR, whereas activation of CREB and NF-kappaB was mediated by PKA, PKC and ERK
Jiao et al., J Neurochem 2007 : Finally, the blockade of NMDA-receptor reduces cocaine induced ERK activation, and inhibits phosphorylation of NR1, Ca ( 2+ ) /calmodulin dependent protein kinase II, and CREB , while inhibiting ERK activation attenuates cocaine induced CREB phosphorylation in the CPu
Martorell et al., Frontiers in bioscience : a journal and virtual library 2008 (Atherosclerosis...) : Mitogenic stimuli up-regulates NOR-1 in endothelial cells ( ECs ) through multiple pathways, including increase of cytosolic calcium, activation of protein kinase C, mitogen activated protein kinase ( MAPK) (ERK1/2 and p38 MAPK ) and downstream activation of cAMP response element binding protein ( CREB )
Cui et al., J Endocrinol 2008 : These findings suggest that coordinated phosphorylation of CREB and C/EBPbeta in response to GH is mediated by ERK1/2 , and that the phosphorylated proteins are part of a regulatory complex that occupies c-fos in vivo to regulate c-fos transcription cooperatively in response to GH
Marais et al., Cardiovasc Drugs Ther 2008 (Myocardial Reperfusion Injury) : Activation of PKA, PKC, ERK and p38 MAPK is involved in preconditioning induced CREB phosphorylation
Park et al., J Leukoc Biol 2008 : gAcrp stimulated CREB phosphorylation was mediated by the activation of both ERK1/2- and cAMP dependent protein kinase (PKA) dependent pathways ... Inhibition of either ERK1/2 or PKA activity prevented gAcrp stimulated CREB phosphorylation, as well as gAcrp stimulated IL-10 promoter activation
Liu et al., Mol Cell Neurosci 2008 : Moreover, the ephrinB1/EphB receptor complex specifically enhances the ability of alpha7-nAChRs to activate the transcription factor CREB , acting through a pathway including a receptor tyrosine kinase, a Src family member, PI3 kinase, and protein kinase A most distally
Ligeza et al., FEBS J 2008 : Silencing of CREB or Elk-1 significantly increased ERK activation observed after 5 min of morphine stimulation
Cao et al., J Neurosci 2009 (Pain) : Thus, when rats were re-exposed to the conditioning context for retrieval of pain experience, ERK and CREB were reactivated in the rACC, and inhibiting ERK activation blocked the expression of F-CPA
Namkoong et al., Cell Signal 2009 : The exchange protein directly activated by cAMP ( Epac ) activator, 8CPT-2Me-cAMP, promoted the Akt/eNOS/NO pathway and ERK phosphorylation, but did not induce CREB phosphorylation and VEGF expression
Poddar et al., J Neurochem 2009 (MAP Kinase Signaling System) : The sustained activation of ERK but a transient activation of CREB together suggest that exposure to homocysteine initiates a feedback loop that shuts off CREB signaling without affecting ERK phosphorylation and thereby facilitates homocysteine mediated neurotoxicity
Bidwell et al., Prostaglandins Other Lipid Mediat 2010 (Glioma...) : Pretreatment of U87-MG cells with the ERK inhibitor PD98059, accentuated ERK inhibition and increased CREB phosphorylation at Ser-133 and CREB-driven transcription stimulated by PGE ( 2 ), suggesting that inhibition of ERK contributes to PGE ( 2 ) -induced CREB activation
Chia et al., Neoplasia (New York, N.Y.) 2011 (Breast Neoplasms) : In this respect, the inhibition of ERK phosphorylation reduces AR expression and CREB1 mediated transcriptional regulation of AR acts as a downstream connector between the AR and ERK signaling pathways in molecular apocrine cells
Wu et al., J Biomed Sci 2011 (Hyperpigmentation...) : Cpc exerted dual antimelanogenic mechanisms by upregulation of MAPK/ERK dependent degradation of MITF and downregulation of p38 MAPK regulated CREB activation to modulate melanin formation
Aroor et al., Eur J Pharmacol 2012 (Fatty Liver, Alcoholic) : In chronic ethanol-binge studies, analysis of the whole cell extracts showed increased phosphorylation of CREB, with no effect on CREB protein levels ; increased phospho-ERK1/2 , and decreased phospho-p38 MAPK
Cheong et al., Endocrinology 2012 : In vitro studies using pharmacological antagonists showed that ERK1/2 was essential for E2-induced CREB phosphorylation in GnRH neurons
Lee et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2012 : Specifically, PS and VS induced ERK phosphorylation, though they had no effect on phosphorylation of the cAMP response element binding protein ( CREB )
Wu et al., Mol Cell Neurosci 2013 : This effect is independent of tPA 's proteolytic properties and leads to a rapid and transient phosphorylation of the extracellular signal regulated kinases1/2 ( ERK1/2 ), with ERK1/2 mediated activation of the cAMP response element binding protein ( CREB ) and induction of the neuroprotective CREB regulated activating transcription factor 3 (Atf3)
Sun et al., Mol Cell Biochem 2013 (Calcium Signaling...) : Intracellular calcium chelator BAPTA-AM, the selective inhibitor of EGFR AG1478 and the selective inhibitor of Erk PD98059 blocked EP1 receptor activation induced CREB phosphorylation and MMP2 expression
Geng et al., Neurochem Int 2013 : Moreover, EphB2 overexpression prevented Aß1-42 oligomer induced downregulation of dephosphorylated p38 MAPK and phosphorylated CREB
Sato et al., Biochem Biophys Res Commun 1997 : A beta ( 1-40 ) induced phosphorylation of p44 and p42 MAP kinases ( Erk1 and Erk2 ) at tyrosine-204, and PD98059, a MEK1 inhibitor, inhibited A beta ( 1-40 ) -induced CREB phosphorylation at serine-133
Xing et al., Mol Cell Biol 1998 : Inhibition of either the ERK/RSK or the p38/MAPKAP kinase 2 pathway only partially blocked NGF induced CREB Ser-133 phosphorylation, suggesting that either pathway alone is sufficient for coupling the NGF signal to CREB activation
Impey et al., Neuron 1998 (Calcium Signaling) : The sequential activation of ERK and Rsk2 by Ca2+ leads to the phosphorylation and transactivation of CREB ... Furthermore, the full expression of the late phase of long-term potentiation ( L-LTP ) and L-LTP associated CRE mediated transcription requires ERK activation, suggesting that the activation of CREB by ERK plays a critical role in the formation of long lasting neuronal plasticity