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CRH — IL6

Text-mined interactions from Literome

Makrigiannakis et al., Neuroendocrinology 1999 (Adenocarcinoma...) : For this purpose we have measured the effects of IL-1, IL-6 and LIF on the activity of CRH promoter inserted in human endometrial cells in culture ... Similarly, IL-6 increased the activity of CRH promoter in a dose dependent fashion, an effect partially reversed by indomethacin
Venihaki et al., J Clin Invest 2001 (Inflammation) : Corticotropin releasing hormone regulates IL-6 expression during inflammation ... We used the corticotropin releasing hormone-deficient ( Crh ( -/- ) ) mouse to elucidate the effect of CRH deficiency on IL-6 expression and IL-6 induced HPA axis activation during turpentine induced inflammation ... The paradoxical increase of plasma IL-6 associated with CRH deficiency suggests that IL-6 release during inflammation is CRH dependent ... These findings, along with the regulation of IL-6 by CRH , support the importance of the interaction between the immune system and the HPA axis in the pathophysiology of inflammatory diseases
De Souza et al., Inflamm Res 2002 : Indomethacin or dipyrone reduced LPS, IL-1beta, IL-6 or TNF-alpha induced fever and CRH release from rat hypothalamus
Zbytek et al., Life Sci 2002 : It is demonstrated for the first time that exogenously added CRH stimulates production of IL-6 and IL-11
Agelaki et al., Infect Immun 2002 (Shock, Septic) : We have found that CRH enhanced lipopolysaccharide (LPS) induced tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 production
Huang et al., Cardiovasc Res 2003 (Coronary Disease) : Stress induced IL-6 release may, therefore, be at least partly due to peripheral Ucn and/or CRH , with Ucn possibly overcompensation for CRH deficiency
Cambronero et al., Regul Pept 1992 : Adrenalectomy does not change CRF secretion induced by interleukin-1 from rat perifused hypothalami
Komori et al., Chem Senses 2003 : Our results indicate that citralva enhances stress induced activation of the hypothalamic-pituitary-adrenal axis by corticotropin releasing hormone (CRH) mediated stimulation of IL-6 , while DMMB enhances the beneficial action of IL-6 without affecting CRH
Maes et al., Neuro Endocrinol Lett 2003 : In one study, CRH significantly decreases IFNgamma production by cultured human peripheral blood immunocytes, whereas in other studies CRH increases the production of cytokines, such as IL-1, IL-2 and IL-6
Ware et al., FEBS Lett 2005 : High CRH may be caused by increased central TNFalpha and IL-6 expression
Leu et al., Cell Immunol 1992 (Inflammation) : Stimulation of interleukin-6 production by corticotropin releasing factor
Lyson et al., Neuroendocrinology 1992 : Involvement of arachidonic acid cascade pathways in interleukin-6 stimulated corticotropin releasing factor release in vitro ... As reported previously, 10 ( -13 ) M IL-6 increased CRF release, which was significantly suppressed by DEX in a dose dependent manner ... The suppression was already highly significant at a concentration of 10 ( -11 ) M DEX and became maximal at 10 ( -7 ) M, at which concentration CRF release was no longer stimulated by IL-6 ... CLO also suppressed IL-6 induced CRF release with a minimal effective dose of 10 ( -9 ) M. Suppression was complete at 10 ( -7 ) and 10 ( -5 ) M. ( ABSTRACT TRUNCATED AT 250 WORDS )
Krause et al., Horm Metab Res 2007 : alpha-Helical-CRF, a CRH antagonistic peptide, annulled the CRH effect on SZ95 sebocyte proliferation and interleukin secretion, while the non-peptidic CRH-R1 selective antagonist antalarmin inhibited the increased production of neutral lipids caused by CRH
Navarra et al., Endocrinology 1991 : IL-6 increased hypothalamic CRH-41 secretion in the range 10-100 U/ml, but had no effect on isolated median eminences incubated in vitro under the same conditions
Kageyama et al., J Endocrinol 2009 : Among them, interleukin (IL)-6 plays a role in the regulation of CRF
Rivier et al., Stress 2001 : These data also illustrate the ability of a CRF antagonist or CRF antibodies to significantly augment IL-6 secretion, which indicates an inhibitory influence of the endogenous peptide in the paradigm we used.As comparable findings were obtained in adrenal-intact and adrenalectomized rats, they suggest that endogenous CRF is involved in the IL-6 response to LPS independently of circulating corticosteroids or other adrenal factors
Sandi et al., Eur J Pharmacol 1995 : This study investigated the possibility that nitric oxide ( NO ) acts as a mediator of interleukin-1 induced CRF release ... The concurrent treatment with NG-nitro-L-arginine and indomethacin ( 14 microM ) -- an inhibitor of prostaglandin production -- reduced interleukin-1 induced CRF release to the same level as NG-nitro-L-arginine alone, suggesting that prostaglandins might interact with NO on this interleukin-1 effect
Angioni et al., Life Sci 1993 : CRH significantly increased IL-6 release from PBMC ( p < 0.01 )
Kakucska et al., Endocrinology 1993 : Endotoxin induced corticotropin releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin-1
Karanth et al., Neuroimmunomodulation 1995 : The inhibitor of cyclooxygenase, indomethacin ( IND ), also blocked IL-2 induced CRF release just as it has previously been shown to block IL-1- and IL-6 induced CRF release
Stephanou et al., Mol Cell Endocrinol 1997 (Arthritis, Experimental) : Increased CRH promoter activity following phorbol ester treatment was inhibited by a dominant negative NF-IL6 mutant, showing that the effects of phorbol ester were principally mediated by C/EBP
Mulchahey et al., Endocrinology 1999 : The expression of both CRF and CRF-BP is positively regulated by forskolin and interleukin-6
Dudley et al., Am J Obstet Gynecol 1999 (Obstetric Labor, Premature...) : The cytokine interleukin 1 stimulates production of corticotropin releasing hormone , and corticotropin releasing hormone in turn regulates cytokine production by immune effector cells