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CRK — TNF

Text-mined interactions from Literome

Sato et al., J Immunol 1999 : TNF-alpha induced tyrosine phosphorylation and enzymatic activation of ERK2, SAPK/JNK, and p38mapk , whereas IL-10 did not induce these events
Hashimoto et al., Biochem Biophys Res Commun 1999 : The results showed that TNF-alpha induced p38 MAP kinase activation and interleukin-6 (IL-6) production by TRX 14 were less than those by the parental L cells and the control transfected L cells ( Neo-1 )
Hashimoto et al., Eur Respir J 1999 : Inhibition of TNF-alpha- and IL-1alpha induced p38 MAP kinase activity by SB 203580 inhibited TNF-alpha- and IL-1alpha induced IL-8 protein production as well as IL-8 messenger ribonucleic acid ( mRNA ) expression, indicating that SB 203580 was effective at the transcriptional level
Wadsworth et al., J Pharmacol Exp Ther 1999 : Monocyte/macrophage production of TNF-alpha is dependent on the mitogen activated protein kinase p38
Hashimoto et al., Allergy 1999 : The results showed that TNF-alpha induced RANTES production and p38 MAP kinase activity in human pulmonary vascular endothelial cells ... Abrogation of p38 MAP kinase activity by SB 203580 repressed TNF-alpha induced p38 MAP kinase activity and RANTES production
Clerk et al., J Mol Cell Cardiol 1999 (MAP Kinase Signaling System) : IL-1 beta and TNF alpha also stimulated p38-MAPK phosphorylation, but the response to IL-1 beta was consistently greater than TNF alpha
Cosulich et al., Carcinogenesis 2000 (MAP Kinase Signaling System) : Here we show that treatment of primary rat hepatocyte cultures with nafenopin causes an increase in bioactive TNF-alpha and that this process requires p38 MAP kinase activity
Hashimoto et al., Allergy 2000 : Regulation by intracellular glutathione of TNF-alpha induced p38 MAP kinase activation and RANTES production by human pulmonary vascular endothelial cells ... However, a regulatory role of intracellular glutathione ( GSH ) in TNF-alpha induced p38 MAP kinase activation and p38 MAP kinase mediated RANTES production has not been determined ... Human pulmonary vascular endothelial cells were exposed to N-acetylcysteine (NAC) or buthionine sulfoximine ( BSO ), and then TNF-alpha induced p38 MAP kinase activation and p38 MAP kinase mediated RANTES production were determined ... The results showed that 1 ) NAC attenuated TNF-alpha induced p38MAP kinase activation and RANTES production 2 ) SB 203580 as the specific inhibitor of p38 MAP kinase activity attenuated TNF-alpha induced RANTES production 3 ) BSO facilitated TNF-alpha induced p38 MAP kinase activation and RANTES production 4 ) SB 203580 attenuated BSO mediated facilitation of TNF-alpha induced RANTES production ... These results indicated that TNF-alpha induced p38 MAP kinase activation and p38 MAP kinase mediated RANTES production by human pulmonary vascular endothelial cells are inversely regulated by intracellular GSH levels
Rutault et al., J Biol Chem 2001 : We have studied the role of ERK and p38 mitogen activated protein ( MAP ) kinase in controlling TNF-alpha mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes
Valladares et al., Endocrinology 2000 : TNFalpha activates extracellular regulated kinase-1/2 ( ERK1/2 ) and p38MAPK
Hashimoto et al., Br J Pharmacol 2001 : N-acetylcysteine attenuates TNF-alpha induced p38 MAP kinase activation and p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells
Hashimoto et al., Clin Exp Allergy 2001 : However, a role of cellular redox regulated by intracellular glutathione ( GSH ) in TNFalpha induced p38 MAP kinase activation and p38 MAP kinase mediated RANTES production by human BECs has not been determined ... TNFalpha induced p38 MAP kinase activation and p38 MAP kinase mediated RANTES production by human BECs were then examined in order to clarify these issues ... These results indicate that cellular redox regulated by GSH is critical for TNF-alpha induced p38 MAP kinase activation and p38 MAP kinase mediated RANTES production by human BECs
Valladares et al., FEBS Lett 2001 : Tumor necrosis factor-alpha (TNF-alpha) activates extracellular regulated kinases ( ERKs ) and p38 mitogen activated protein kinase ( p38MAPK ), and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes
Surapisitchat et al., Proc Natl Acad Sci U S A 2001 (MAP Kinase Signaling System) : Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells : Inhibitory crosstalk among MAPK family members
Saijonmaa et al., J Vasc Res 2001 : TNF-alpha and IL-1beta activated p44/42 and p38 mitogen activated protein kinases ( MAPKs ) in HUVECs ; this was inhibited by the specific inhibitors of these kinases, PD98059 and SB202190, respectively
Guo et al., J Cell Biochem 2001 : Treatment of the cells with TNF-alpha alone had little effect on their viability, but they became very sensitive to apoptosis when treated with TNF-alpha in the presence of the p38 inhibitor SB 203580
Slomiany et al., IUBMB Life 2001 (Gastritis...) : The animal model of H. pylori lipopolysaccharide (LPS) induced gastritis was used to study the role of extracellular signal regulated kinase ( ERK ) and p38 mitogen activated protein kinase ( MAPK ) in the mucosal release of tumor necrosis factor-alpha (TNF-alpha) and endothelin-1 (ET-1) in response to H. pylori infection
Mielke et al., Mol Cell Neurosci 2002 (Nerve Degeneration) : TNFalpha induced in dPC12, but not nPC12, a biphasic activation of JNKs with a rapid transient JNK1 activation and a second persistent activation of JNK1 and JNK2 paralleled by phosphorylation of c-Jun ; in contrast, TNFalpha did not activate p38 kinase
Azzolina et al., Cytokine 2002 (MAP Kinase Signaling System) : The results reveal that the induction of TNF-alpha expression and histamine exocytosis by exposure of rat PMC to substance P requires the activation of p38 and JNK MAPKs pathways
Cui et al., Neurobiol Dis 2002 : The effect of TNF alpha was dependent on the p55 TNF alpha receptor and activation of MAP kinase p38
Laufer et al., Osteoarthritis Cartilage 2002 : Also for SB 202190 this correlation in inhibition of IL-1beta and TNFalpha synthesis ( IC ( 50 ) 's : 0.055 microM and 1.01 microM ) and p38-MAP kinase inhibition ( IC ( 50 ) : 0.088 microM ) could be shown
Wang et al., J Neurochem 2003 (MAP Kinase Signaling System) : CRH effects on TNF-alpha release were also inhibited by specific inhibitors of MEK, the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 mitogen activated protein kinase ( SB203580 ), but not by H89
Pol et al., J Invest Dermatol 2003 : Previously, it was shown that in cultured keratinocytes, elafin expression is induced by serum or tumor necrosis factor-alpha , and that expression is suppressed by retinoids, dithranol, and p38 mitogen activated protein kinase inhibitors
Garcia-Cao et al., EMBO Rep 2003 (MAP Kinase Signaling System) : Consistent with recent reports demonstrating the antagonistic actions of NF-kappaB and c-Jun amino-terminal kinase (JNK) signalling, we have found that Par4 ( -/- ) cells show a reduced activation of the sustained phase of JNK and p38 stimulation by TNF-alpha and interleukin 1
Yoshizumi et al., J Pharmacol Sci 2003 (Arteriosclerosis) : TNF-alpha activated ERK1/2, JNK, and p38 maximally at 15 min in HUVEC
Chae et al., Res Commun Mol Pathol Pharmacol 2001 : In this study, IFN-gamma enhancement of TNF-alpha induced NF-kappaB binding affinity as well as p38 MAP kinase activation was observed
Devin et al., EMBO Rep 2003 (MAP Kinase Signaling System) : We found that TNF induced activation of ERK, p38 and JNK is decreased in Rip ( -/- ) cells
Comalada et al., Am J Physiol Cell Physiol 2003 : JNK mainly regulates TNF-alpha transcription and apoptosis, whereas ERK and p38 contribute to the regulation of TNF-alpha production, probably through posttranscriptional mechanisms
Lee et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : In transfection studies, RIP1 and TRAF2 stimulate p38 MAP kinase activation, and dominant negative forms of RIP1 and TRAF2 inhibit TNF-alpha induced p38 MAP kinase activation
Kang et al., J Biol Chem 2004 : Tumor necrosis factor-alpha (TNF-alpha) induces the activation of all three types of mitogen activated protein kinase ( MAPK ) : c-Jun NH ( 2 ) -terminal kinase ( JNK ), p38 , and extracellular signal regulated kinase ( ERK )
Jeong et al., J Biol Chem 2004 : The TNF-alpha induced activation of c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinases ( MAPKs ), however, was promoted by depletion of TRP14 but not by that of Trx1
Tudan et al., Cell Signal 2004 : Furthermore, CPPD crystals repressed the TNF-alpha associated 6-fold induction of p38 kinase phosphotransferase activity to levels associated with CPPD crystal incubation alone in a PD98059 ( 20 ng/ml ) and Wortmannin ( 100 nM ) sensitive manner
Zhang et al., Infect Immun 2004 : TNF-alpha also induced the phosphorylation of p38
Habelhah et al., EMBO J 2004 : Here, we demonstrate that TRAF2 ubiquitination is required for TNFalpha induced activation of JNK but not of p38 or NF-kappaB ... Inhibition of Ubc13 expression by RNAi resulted in inhibition of TNFalpha induced TRAF2 translocation and impaired activation of JNK but not of IKK or p38
Lin et al., Cell Signal 2004 : This hypothesis was further supported by that TNF-alpha induced a transient activation of p42/p44 and p38 MAPKs in a time-and concentration dependent manner
Asehnoune et al., J Immunol 2004 : Antioxidant treatment of LPS stimulated neutrophils also inhibited the production of proinflammatory cytokines ( TNF-alpha , macrophage inflammatory protein-2, and IL-1beta ), as well as activation of the kinases IkappaB kinase alpha, IkappaB kinase beta, p38 , Akt, and extracellular receptor activated kinases 1 and 2
Ling et al., Biochem J 2004 (Inflammation) : Stimulation of human skin fibroblasts or articular chondrocytes with IL-1 or TNF-alpha in the presence of HC-gp39 resulted in a marked reduction of both p38 mitogen activated protein kinase and stress activated protein kinase/Jun N-terminal kinase phosphorylation, whereas nuclear translocation of nuclear factor kappaB proceeded unimpeded
Fotheringham et al., Eur J Pharmacol 2004 : Activation of adenosine receptors inhibits tumor necrosis factor-alpha release by decreasing TNF-alpha mRNA stability and p38 activity
Hernandez et al., Diabetologia 2004 (Insulin Resistance) : Rosiglitazone treatment impaired TNF-alpha activation of p38 and p42/p44MAPK, restoring insulin signalling and leading to normalisation of glucose uptake
Yoshino et al., Am J Reprod Immunol 2004 (Endometriosis) : IL-1beta, TNFalpha and H ( 2 ) O ( 2 ) stimulated the phosphorylation of ERK, p38 and JNK, while the total amounts of proteins of the respective MAPKs were virtually the same compared with those in the unstimulated controls
Scherberich et al., Oncogene 2005 (Breast Neoplasms...) : Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro
Goral et al., J Immunol 2005 (Inflammation) : Specifically, the study focused on the proinflammatory cytokines IL-6 and TNF-alpha and activation of p38 and ERK1/2 MAPKs after a single in vivo exposure to physiologically relevant level of ethanol followed by ex vivo stimulation with specific TLR ligands ... However, inhibitors of serine/threonine protein phosphatase type 1 and type 2A significantly increased IL-6 and TNF-alpha levels, and prolonged activation of p38 and ERK1/2 when triggered by TLR4 and TLR9 ligands
Nimah et al., Shock 2005 : LPS induced expression of TNF-alpha is partly regulated by the p38 mitogen activated protein ( MAP ) kinase, which post-transcriptionally stabilizes TNF-alpha mRNA ... We hypothesized that MKP-1 expression induced during tolerance regulates TNF-alpha expression by inhibiting p38 activity
Li et al., J Biol Chem 2005 : Our study suggests that TNFalpha induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha induced ASK1-JNK/p38 activation
Li et al., J Biol Chem 2005 (Arteriosclerosis...) : The increases in TNF-alpha and IL-6 mRNA and protein were mediated by FC-induced activation of the IkappaB kinase/NF-kappaB pathway as well as activation of MKK3/p38 , Erk1/2, and JNK1/2 mitogen activated protein kinases ( MAPK )
Murali et al., Proc Natl Acad Sci U S A 2005 (Arthritis, Experimental) : TNF-alpha induced NF-kappaB and p38 kinase activities and clinical symptoms of collagen induced arthritis in mice were all diminished
Komine et al., J Invest Dermatol 2005 : RXM partially suppressed p38 phosphorylation and NFkappaB-driven luciferase activity induced by TNFalpha and IFNgamma
Kim et al., Cardiovasc Res 2006 : Furthermore, APE1/ref-1 overexpression inhibited the TNF-alpha induced increase in intracellular superoxide and p38 MAPK phosphorylation
Choo et al., Int J Cancer 2006 (Colonic Neoplasms...) : Moreover, knockdown of endogenous TAK1 using small interfering RNA ( siRNA ) suppressed the TNF-alpha induced JNK/p38 activation, migration and pulmonary metastasis
Koss et al., J Immunol 2006 (MAP Kinase Signaling System) : This study tested the hypothesis that ERM proteins are phosphorylated on this critical threonine residue through TNF-alpha induced activation of PKC and p38 and modulate permeability increases in pulmonary microvascular ECs
Johansen et al., J Immunol 2006 (Psoriasis) : This increase in TNF-alpha protein expression was completely blocked by the p38 inhibitor, SB202190
Kimura et al., Life Sci 2006 (Myocardial Ischemia) : The increases in TNF alpha production, as well as phosphorylation of p38 MAP kinase and S6 kinase after ischemia were inhibited by IP or p38 MAP kinase inhibitors ( SB203580, FR167653 )
Xue et al., Vascul Pharmacol 2006 (MAP Kinase Signaling System) : We observed that EPA or DHA alone significantly reduced the TNF-alpha induced activation of p38 and JNK kinases at a concentration of 20 microM, but EPA is a more potent inhibitor than DHA ... Meanwhile, both EPA and DHA significantly attenuated the TNF-alpha induced expression of p38 and ERK1/2 mRNA, and DHA but not EPA also reduced the TNF-alpha induced JNK mRNA expression
Higashimoto et al., Cytokine 2006 (Chromosome Aberrations) : In cells progressing through S-phase, TNFalpha activation of IKK, JNK, and p38 is significantly reduced
Zhou et al., J Bone Miner Res 2006 (Fractures, Bone) : TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats ... The results show that TNF-alpha mediates p38 activation, which influences the recruitment, proliferation, and osteoblast differentiation of mesenchymal cells and negatively regulates bone formation at the injured growth plate ... In addition, activation of p38 was blocked in rats treated with TNF-alpha antagonist, suggesting a role of TNF-alpha in p38 activation
Thirunavukkarasu et al., Hepatology 2006 (Disease Models, Animal...) : In conclusion, endotoxin induced synthesis of NO, TNF-alpha , and IL-6 in HSCs is mediated by p38 and NF-kappaB, with involvement of H ( 2 ) O ( 2 ) in TNF-alpha production
Laza-Stanca et al., J Virol 2006 (Asthma...) : Finally, we established the requirement for NF-kappaB but not p38 mitogen activated protein kinase in induction of TNF-alpha
Smith et al., Br J Pharmacol 2006 (Pneumonia) : p38 MAPK may regulate cytokine production, therefore, the effect of two p38 MAPK inhibitors, SB239063 and SD-282, on the release of TNF-alpha , GM-CSF and IL-8 from human macrophages was investigated
Shi et al., Osteoarthritis Cartilage 2007 (Osteoarthritis) : Upon examination of the signaling components, we found that TNFalpha was a potent activator of p38 , p44/42, p54/46 MAPK, and IkappaBalpha ( IkappaBalpha )
Qin et al., Diabetes 2007 (Disease Models, Animal...) : Ex vivo experiments using freshly isolated enterocytes also showed TNF-alpha induced p38 phosphorylation and intestinal apoB48 overproduction, effects that could be blocked by SB203580 ... Enterocytes were found to have detectable levels of both TNF-alpha receptor types ( p55 and p75 ), and antibodies against either of the two TNF-alpha receptors partially blocked the stimulatory effect of TNF-alpha on apoB48 production and p38 phosphorylation
Nizamutdinova et al., Int Immunopharmacol 2007 (Atherosclerosis) : It also blocked the TNF-alpha induced phosphorylation of p38 and extracellular signal regulated kinase ( ERK ), which are involved in regulating ICAM-1 production by TNF-alpha
Zhang et al., J Biol Chem 2007 (MAP Kinase Signaling System) : RIP1 mediated AIP1 phosphorylation at a 14-3-3 binding site is critical for tumor necrosis factor induced ASK1-JNK/p38 activation
Kesherwani et al., Cytokine 2007 : The expression of TNF-alpha, IL-1beta and IL-12 was down regulated in the presence of PD98059 and SB202190 in a dose dependent manner, suggesting the involvement of p42/44 and p38 in ConA induced production of TNF-alpha , IL-1beta and IL-12 by macrophages
Cindrova-Davies et al., Am J Pathol 2007 (Pre-Eclampsia) : Vitamin administration or p38 pathway inhibition also reduced cyclooxygenase-2 expression, tumor necrosis factor-alpha and interleukin-1 beta secretion, and the levels of apoptosis
Yoon et al., Osteoarthritis Cartilage 2008 (Chondrosarcoma) : We found that alpha-MSH pretreatment inhibited TNF-alpha induced MMP-13 expression and p38 kinase phosphorylation in HTB-94 human chondrosarcoma cells
Lagoumintzis et al., Scand J Immunol 2008 (Pseudomonas Infections) : TNF-alpha levels were significantly reduced by ERK1/2 inhibitor ( PD98059 ), or p38 inhibitor ( SB203580 )
Brechter et al., Bone 2008 : p38 and JNK were important for TNF-alpha induced stimulation of B1 receptors, whereas NF-kappaB, p38 and JNK were involved in TNF-alpha induced expression of B2 receptors
Faurschou et al., Exp Dermatol 2008 : In this work, we demonstrate that in the premalignant keratinocyte cell line HaCaT, TNF-alpha activates Akt, ERK1/2 and p38
Raffetto et al., Vasc Endovascular Surg 2008 (Varicose Ulcer) : TNF-alpha and IL-1beta significantly increase p38 expression
Kim et al., J Endocrinol 2008 (Insulinoma) : The TNF-alpha treatment was thought to activate c-Jun N-terminal kinase (JNK), p38 mitogen activated protein kinase ( MAPK ), and NF-kappaB inflammatory signals, since TNF-alpha increased phospho-JNK and phospho-p38 and reduced I kappaB levels
Langer et al., PloS one 2008 (MAP Kinase Signaling System) : Peptidoglycan stimulated monocyte p38 mitogen activated protein kinase and p38 activity was required for TNFalpha production by the cells
Ming et al., BMC cardiovascular disorders 2009 : Moreover, the inhibitory effect of L-norvaline was not reversed by the NOS inhibitor L-NAME and L-norvaline did not interfere with TNFalpha induced activation of NF-kappaB, JNK, p38mapk , while it inhibited p70s6k ( S6K1 ) activity
Kurada et al., J Biol Chem 2009 (Neoplasms) : We investigated the physiological role of endogenous MAPK activating death domain containing protein ( MADD ), a splice variant of the IG20 gene, that can interact with TNFR1 in tumor necrosis factor-alpha (TNFalpha) induced activation of NF-kappaB, MAPK, ERK1/2, JNK, and p38
Noguchi et al., J Endod 2009 : After the pretreatment of LPS with O ( 3 ) aq, effects of LPS and O ( 3 ) aq-treated LPS on cell viability ; calcification ability ; expression of cyclooxygenase 2 (COX-2), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) ; and activation of p38 of KN-3 cells were examined
Bruun et al., Mol Cell Endocrinol 2009 : SOCS-3 inhibited TNFalpha induced phosphorylation of the mitogen activated protein kinases ERK1/2, p38 and JNK in INSr3 # 2 cells and in primary rat islets
Cuong et al., Life Sci 2009 (Inflammation...) : Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha , interleukin (IL)-6, and IL-12 p40, and the activation of ERK1/2 and p38
Bae et al., Inflammation 2010 (Acute Lung Injury...) : In the present study, production of TNF-alpha and MIP-2 and activation of extracellular signal regulated kinases ( ERK ) 1/2, c-Jun amino terminal kinases (JNK) and p38 in RAW264.7 cells were measured
Knobloch et al., Thorax 2009 : Both TNFalpha and ET-1 activated p38 ( MAPK ) and extracellular signal regulated kinase ( ERK ) -1/-2 signalling
Xing et al., Microvasc Res 2010 (Inflammation) : Both LPS and TNFalpha caused sustained activation of p38 and ERK1/2 MAP kinases, increased phosphorylation and degradation of negative regulator of NFkappaB signaling IkBalpha, and increased Rho-kinase mediated phosphorylation of myosin phosphatase MYPT1 leading to accumulation of phosphorylated myosin light chains
Rakkestad et al., Inhal Toxicol 2010 (Inflammation) : MEHP also induced phosphorylation of MAPK p38, while the p38 inhibitor SB 202190 reduced MEHP induced TNF-alpha , suggesting a p38 dependent cytokine production
Ravindranath et al., J Immunol 2009 (Acute Lung Injury...) : In human pulmonary microvascular ECs, AR activity was required for TNF-alpha induced activation of the Rho kinase/MKK4/JNK pathway and IL-6 production, but not p38 activation or ICAM-1 expression
Stjernberg-Salmela et al., Rheumatology (Oxford) 2010 (Familial Mediterranean Fever) : Low TNF induced NF-kappaB and p38 phosphorylation levels in leucocytes in tumour necrosis factor receptor associated periodic syndrome
Chen et al., Vet Res 2011 : Administration of an inhibitor specific to p38 or JNK resulted in varying degrees of attenuation on ApxI induced cytokine expression, suggesting the differential regulatory roles of p38 and JNK in IL-1ß, IL-8 and TNF-a production
Bølling et al., Toxicol Lett 2012 : Experiments using specific inhibitors suggested that MEHP induced activation of both p38 and the phosphoinositide-3 (PI3) kinase/Akt pathway were involved in the release of TNF-a ; whereas only PI3kinase seemed to be involved in differentiation
Ma et al., J Pharmacol Sci 2012 : Moreover, yangonin did not inhibit TNF-a induced activation of p38 , but it significantly impaired activation of extracellular signal regulated kinase 1/2 and stress activated protein kinase/c-Jun NH ( 2 ) -terminal kinase
Kim et al., Mol Cells 2012 (Inflammation) : TNF-a also increased the production of inducible nitric oxide synthase (iNOS), nitric oxide ( NO ), and intercellular adhesion molecule 1 ( ICAM-1 ) through activation of p38 mitogen activated protein kinase ( MAPK ) from HT-29 cells
Kazama et al., Eur J Pharmacol 2012 : An antioxidant drug, N-acetyl-l-cysteine significantly inhibited TNF-a induced phosphorylation of p38 and JNK
Lacerda et al., PloS one 2012 : All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit tumor necrosis factor a ( TNF-a production in cultured macrophages ) and in vitro MAPK p38a inhibition
Alshorafa et al., Tohoku J Exp Med 2012 (Psoriasis) : In addition, H ( 2 ) S inhibited TNF-a mediated activation of p38 , extracellular-signal regulated kinase and nuclear factor kappa B
Abi Saab et al., Oncogenesis 2012 : Our results show that MLK4ß inhibits sorbitol- and tumor necrosis factor induced activation of p38
Tsai et al., PloS one 2013 : Bla g 2 can stimulate up-regulation of inflammatory cytokines including TNF-alpha and IL-6 and activation of nuclear factor kappa B ( NF-kB/p65 ), p38 mitogen activated protein kinase ( p38 ), ERK, and JNK in cultured fibrocytes
Tanigawa et al., Immunopharmacol Immunotoxicol 2013 : Acacetin suppressed the TNF-a induced phosphorylation of p38 but did not inhibit TNF-a induced phosphorylations of JNK and ERK
Ishizuka et al., Proc Natl Acad Sci U S A 1997 : Aggregation of FcepsilonRI stimulated MEK kinase 1 (MEKK1) activity, which activates JNK kinase (JNKK), the kinase that phosphorylates and activates JNKs. Expression of activated MEKK1 ( DeltaMEKK1 ) in MC/9 cells strongly stimulated JNK activity but only weakly stimulated p38 activity, and it induced a large activation of TNF-alpha promoter regulated luciferase gene expression ... Wortmannin, an inhibitor of phosphatidylinositol 3-kinase, diminished FcepsilonRI mediated TNF-alpha synthesis, significantly blunted JNK activation and TNF-alpha promoter-driven luciferase expression, and only weakly inhibited p38 kinase activation
Zu et al., J Immunol 1998 : Protein phosphorylation analysis of cellular MAP kinases indicates that exposure of human neutrophils to chemotactic factor FMLP as well as granulocyte-macrophage CSF, PMA, or ionomycin rapidly induced the activation of p38 and p44/42 MAP kinases, but stimulation with inflammatory cytokine TNF-alpha triggered the activation of p38 MAP kinase only
Pyo et al., Neuroreport 1998 : Both inhibitors of p38 ( SB203580 ) and ERK pathway ( PD098059 ) reduced LPS induced nitric oxide ( NO ) release and Abeta induced tumor necrosis factor-alpha (TNF-alpha) release
Hoffmeyer et al., J Biol Chem 1999 : Here we show that extracellular signal regulated kinase ( ERK ), c-Jun N-terminal kinase (JNK), and p38-mitogen activated protein kinase ( MAPK ) pathways control the transcription and synthesis of TNF-alpha in A3.01 T cells that produce the cytokine upon T cell activation by costimulation with 12-O-tetradecanoylphorbol-13-acetate ( TPA ) and ionomycin