Gene interactions and pathways from curated databases and text-mining

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CRKL — SRC

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Li et al., Mol Cell Biol 2003 : Consistent with the ability of CrkL to biochemically associate with Cas, we found that Src triggers translocation of CrkL to focal adhesions (FAs) in a manner dependent on Cas ... These results therefore indicate a role for CrkL in mediating Src signaling by activating small G proteins at focal adhesions
Fiskus et al., Clin Cancer Res 2006 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Treatment with dasatinib attenuated the levels of autophosphorylated Bcr-Abl, p-CrkL , phospho-signal transducer and activator of transcription 5 ( p-STAT5 ), p-c-Src, and p-Lyn ; inhibited the activity of Lyn and c-Src ; and induced apoptosis of the cultured CML cells