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CRKL — SRC
Pathways - manually collected, often from reviews:
-
BioCarta links between pyk2 and map kinases:
PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL)
→
RAC1
(modification, activates)
-
BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL)
→
p130CAS (BCAR1)
(modification, collaborate)
-
BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL)
→
PYK2/SRC complex (PTK2B-SRC)
(modification, collaborate)
-
BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL)
→
CRKL
(modification, collaborate)
-
BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
PYK2/SRC complex (PTK2B-SRC)
→
CRKL
(modification, collaborate)
-
BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL)
→
RAC1
(modification, activates)
-
BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL)
→
None
(modification, activates)
-
BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL)
→
None
(modification, activates)
-
BioCarta links between pyk2 and map kinases:
PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL)
→
p130CAS (BCAR1)
(modification, collaborate)
-
BioCarta links between pyk2 and map kinases:
PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL)
→
PYK2/SRC complex (PTK2B-SRC)
(modification, collaborate)
-
BioCarta links between pyk2 and map kinases:
PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL)
→
CRKL
(modification, collaborate)
-
BioCarta links between pyk2 and map kinases:
PYK2/SRC complex (PTK2B-SRC)
→
CRKL
(modification, collaborate)
Text-mined interactions from Literome
Li et al., Mol Cell Biol 2003
:
Consistent with the ability of CrkL to biochemically associate with Cas, we found that
Src triggers translocation of
CrkL to focal adhesions (FAs) in a manner dependent on Cas ... These results therefore indicate a
role for
CrkL in mediating
Src signaling by activating small G proteins at focal adhesions
Fiskus et al., Clin Cancer Res 2006
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Treatment with dasatinib attenuated the levels of autophosphorylated Bcr-Abl,
p-CrkL , phospho-signal transducer and activator of transcription 5 ( p-STAT5 ), p-c-Src, and p-Lyn ;
inhibited the activity of Lyn and
c-Src ; and induced apoptosis of the cultured CML cells