◀ Back to TNF
CSRP1 — TNF
Text-mined interactions from Literome
Hu et al., Diabetes 2004
(Diabetes Mellitus, Type 2...) :
Elevated
CRP levels are a strong independent predictor of type 2 diabetes and may
mediate associations of
TNF-alphaR2 and IL-6 with type 2 diabetes
Singh et al., Arterioscler Thromb Vasc Biol 2005
(Atherosclerosis...) :
CRP increased interleukin (IL)-1beta and
tumor necrosis factor (TNF)-alpha
Singh et al., Arterioscler Thromb Vasc Biol 2006
:
Also,
CRP alone
increased secretion of IL-8, IL-6, and
tumor necrosis factor from HMDMs and did not inhibit LPS induced secretion of these cytokines
Dowton et al., Pediatr Res 1991
(Acute-Phase Reaction) :
Studies of immature hamsters after birth show that the
responses of
CRP and SAA genes to lipopolysaccharide,
tumor necrosis factor , IL-1, and IL-6 are reduced when compared with induction of mRNA accumulation for these acute phase reactants in adult animals
Choi et al., Nucleic Acids Res 2007
:
We investigated the mechanism of
TNF-alpha induced
CRP expression and found that the p50 subunit of NF-kappaB was responsible for the transcriptional activation of CRP
Liu et al., Inflammation 2011
(Atherosclerosis) :
TLR4 knockdown significantly inhibited
CRP induced
TNF-a generation, and p38 mitogen activated protein kinase ( MAPK ) blocker SB203580 depressed TLR4 expression and TNF-a production initiated by CRP in VSMCs
Li et al., Mediators Inflamm 2012
:
Actinomycin D treatment completely prevented
CRP and
TNF-a induction of PAPP-A mRNA and protein expression
Gabay et al., Clin Exp Immunol 1995
(Carcinoma, Hepatocellular) :
Since previous studies on the contributions of cytokine inhibitors in connective tissues diseases suggested that IL-1 and
tumour necrosis factor-alpha (TNF-alpha) might
play an important role in the regulation of
CRP , we decided to examine in more detail the respective roles of IL-1 beta, IL-6, and TNF-alpha and their inhibitors in the production of APP by human primary hepatocytes versus the hepatoma cell line PLC/PRF/5 ... In the hepatoma cell line, IL-1 beta and/or
TNF-alpha had synergistic effects with IL-6 on the production of
CRP and SAA