Gene interactions and pathways from curated databases and text-mining

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CSRP1 — TNF

Text-mined interactions from Literome

Hu et al., Diabetes 2004 (Diabetes Mellitus, Type 2...) : Elevated CRP levels are a strong independent predictor of type 2 diabetes and may mediate associations of TNF-alphaR2 and IL-6 with type 2 diabetes
Singh et al., Arterioscler Thromb Vasc Biol 2005 (Atherosclerosis...) : CRP increased interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha
Singh et al., Arterioscler Thromb Vasc Biol 2006 : Also, CRP alone increased secretion of IL-8, IL-6, and tumor necrosis factor from HMDMs and did not inhibit LPS induced secretion of these cytokines
Dowton et al., Pediatr Res 1991 (Acute-Phase Reaction) : Studies of immature hamsters after birth show that the responses of CRP and SAA genes to lipopolysaccharide, tumor necrosis factor , IL-1, and IL-6 are reduced when compared with induction of mRNA accumulation for these acute phase reactants in adult animals
Choi et al., Nucleic Acids Res 2007 : We investigated the mechanism of TNF-alpha induced CRP expression and found that the p50 subunit of NF-kappaB was responsible for the transcriptional activation of CRP
Liu et al., Inflammation 2011 (Atherosclerosis) : TLR4 knockdown significantly inhibited CRP induced TNF-a generation, and p38 mitogen activated protein kinase ( MAPK ) blocker SB203580 depressed TLR4 expression and TNF-a production initiated by CRP in VSMCs
Li et al., Mediators Inflamm 2012 : Actinomycin D treatment completely prevented CRP and TNF-a induction of PAPP-A mRNA and protein expression
Gabay et al., Clin Exp Immunol 1995 (Carcinoma, Hepatocellular) : Since previous studies on the contributions of cytokine inhibitors in connective tissues diseases suggested that IL-1 and tumour necrosis factor-alpha (TNF-alpha) might play an important role in the regulation of CRP , we decided to examine in more detail the respective roles of IL-1 beta, IL-6, and TNF-alpha and their inhibitors in the production of APP by human primary hepatocytes versus the hepatoma cell line PLC/PRF/5 ... In the hepatoma cell line, IL-1 beta and/or TNF-alpha had synergistic effects with IL-6 on the production of CRP and SAA