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CTGF — TNF
Text-mined interactions from Literome
Liu et al., Zhonghua Gan Zang Bing Za Zhi 2001
(Liver Cirrhosis) :
To investigate the
effect of
tumor necrosis factor alpha (TNF-alpha) on the expression of
connective tissue growth factor (CTGF) in rat hepatic stellate cells (HSC) in vitro
Villacorta et al., Circ Res 2003
:
On the other hand,
tumor necrosis factor-alpha reduced the expression of
CTGF , an effect that was reversed by antioxidants
Zarrinkalam et al., Kidney Int 2003
(Peritonitis) :
In contrast, platelet derived growth factor ( PDGF ), epidermal growth factor (EGF), and
tumor necrosis factor-alpha (TNF-alpha) had no measurable effects on
CTGF mRNA expression
Kunzmann et al., Am J Physiol Lung Cell Mol Physiol 2007
(Bronchopulmonary Dysplasia...) :
TGF-beta1 induced
CTGF expression can be
blocked by
TNF-alpha
Karger et al., Cell Signal 2008
:
Transforming growth factor-beta1, activin A and
tumor necrosis factor-alpha enhanced expression of the
CTGF gene, while interferon-gamma displayed the opposite effect
Yu et al., Cell Signal 2009
:
TNF-alpha suppressed TGF-beta induced
CTGF expression by switching the binding preference of p300 from Smad4 to p65 ... In this study, we found the inhibitory
effect of
TNF-alpha on TGF-beta induced
CTGF expression in WT but not p65-/-MEF cells
Nozawa et al., Arthritis Res Ther 2009
(Arthritis, Rheumatoid...) :
In addition, tumour necrosis factor (TNF)alpha can induce the CTGF production from synovial fibroblasts even though
TNFalpha can oppositely
inhibit the production of
CTGF from chondrocytes ... These results indicate that aberrant
CTGF production
induced by
TNFalpha plays a central role for the abnormal osteoclastic activation in RA patients
Xiao et al., Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2011
(Liver Cirrhosis...) :
Paeoniflorin may exert its effects by inhibiting the serum level of
TNF-alpha and down
regulating the expression of
CTGF and PDGF proteins
Laug et al., PloS one 2012
:
IFN-? and
TNF-a synergize to
inhibit CTGF expression in human lung endothelial cells ... IFN-? and
TNF-a down-regulated
CTGF in human LEC at the promoter-, transcriptional- and translational-level in a dose- and time dependent manner ... Besides the inhibitory
effect of IFN-? and
TNF-a alone on
CTGF expression and LEC proliferation, these cytokines had an additive inhibitory effect on proliferation as well as on CTGF expression when administered together ... In addition, an additive
effect of IFN-? and
TNF-a on inhibition of
CTGF expression and cell proliferation could be found