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CXCL1 — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Devalaraja et al., Cancer Res 1999
(Melanoma) :
We also show here that the resultant elevated nuclear
NF-kappaB ( p50/p65 ) in these cells is
responsible for the increased basal transcription of
MGSA/GRO-alpha ... Cotransfection of a 350-bp MGSA/GRO-alpha promoter-luciferase reporter construct with either the dominant negative IKK-alpha or the repressors of NF-kappaB, the IkappaB-alpha wild type or mutants lacking the inducible phosphorylation sites, demonstrates that the increased basal
MGSA/GRO-alpha transcription in the Hs294T cells is
due to the enhanced nuclear activation of
NF-kappaB
Wang et al., J Biol Chem 2001
(Cell Transformation, Neoplastic) :
We show here that either exogenous addition or continuous expression of
MGSA/GROalpha in immortalized melanocytes
enhances NF-kappaB activation, as well as mitogen activated protein ( MAP ) kinase kinase kinase ( MEKK) 1, MAP kinase kinase (MEK) 3/6, and p38 MAP kinase activation ... Expression of dominant negative M-Ras ( S27N ), dominant negative MEKK1 ( K432M ), or specific chemical inhibitors for p38 MAP kinase ( SB202190 and SB203580 ) block MGSA/GROalpha induced NF-kappaB transactivation, demonstrating that Ras, MEKK1, and p38 are involved in the signal pathways of
MGSA/GROalpha activation of
NF-kappaB
Loukinova et al., Int J Cancer 2001
(Carcinoma, Squamous Cell...) :
The enhanced expression of
Gro-1 gene by SCC is
regulated by activation of
nuclear factor-kappaB (NF-kappaB) , leading to accelerated tumor growth, angiogenesis and metastasis in vivo
Méndez-Samperio et al., J Interferon Cytokine Res 2002
:
Finally, two specific
NF-kappa B inhibitors, sulfasalazine and caffeic acid phenetyl ester ( CAPE ), strongly
inhibited the production of
CXCL-8 by human monocytes infected with M. bovis
Chandrasekar et al., J Biol Chem 2004
(Arteriosclerosis...) :
In conclusion,
CXCL16 is a potent and direct
activator of
NF-kappaB and induces kappa B-dependent proinflammatory gene transcription
Si et al., J Immunol 2004
(Acquired Immunodeficiency Syndrome) :
Interestingly, although LPS induced
IL-8/CXCL8 was
dependent on
NF-kappaB , the baseline or 15d-PGJ ( 2 ) -mediated IL-8/CXCL8 production was NF-kappaB independent
Cinatl et al., Int J Mol Med 2005
(Colonic Neoplasms...) :
High hydrocortisone concentrations ( > or =50 microg/ml ) completely prevented increased DNA binding activity of AP-1 and
NF-kappaB and
inhibited up-regulation of
CXCL8 and CXCL10, but did not reduce chemokine expression to basal levels
Keshamouni et al., Neoplasia (New York, N.Y.) 2005
(Carcinoma, Non-Small-Cell Lung...) :
Similarly, an inhibitor of
NF-kappa B activation ( PDTC ) also
blocked CXCL8 , CXCL5, and CXCL1 production, consistent with their NF-kappa B-dependent regulation
Edwards et al., Mol Immunol 2007
:
Focusing on CXCL8, both rhinovirus infection and dsRNA treatment
required IkappaB kinase-beta for induction of
CXCL8
D'Aversa et al., J Neurosci Res 2008
(AIDS Dementia Complex...) :
Gel shift analyses demonstrated that
NFkappaB and AP-1, but not C/EBPbeta,
mediate microglial
CXCL8 production
Yang et al., Mol Immunol 2008
(Escherichia coli Infections...) :
Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate
NF-kappaB in mammary epithelial cells and to quickly
induce TNFalpha and interleukin-8 (
CXCL8 ) expression in the udder
Bachmeier et al., Carcinogenesis 2008
(Breast Neoplasms) :
Using small interfering RNA techniques, we elucidated the underlying molecular mechanism revealing that reduction of
CXCL1 and -2 messenger RNA levels is
NFkappaB dependent and requires intact IkappaBalpha expression
Bischoff et al., J Cell Biochem 2008
:
NF-kappaB inhibition
resulted in a decrease in
CXCL8 levels in hMSCs grown in non-OGM
Guillot et al., Infect Immun 2008
(Cryptococcosis...) :
Intracellular signaling analysis demonstrated that TNF-alpha and
KC/CXCL1 production was
regulated by
NF-kappaB and phosphatidylinositol 3 kinase in both strains ; however, SJL/J macrophages exhibited heightened and prolonged activation in response to C. neoformans infection compared to that of C57BL/6J
Martin et al., J Biol Chem 2009
:
Furthermore, we identified the components of the CBM complex, Carma3, Bcl10, and Malt1, as key mediators of the
CXCL8/IL8 induced
NFkappaB activation and VEGF up-regulation
Ho et al., J Immunol 2009
:
In contrast, NE did not induce NRF expression in A549 and Beas-2B cells, where NE only stimulates
NF-kappaB activation and
IL-8/CXCL8 induction
Khalaf et al., BMC immunology 2010
(Inflammation) :
The present study shows that
NF-kappaB regulated IL-6 but not
CXCL8
Le Dréau et al., Glia 2010
:
Using a panel of kinase inhibitors, we demonstrated that NOV action on CCL2 and
CXCL1 production
involved a
Rho/ROCK/JNK/NF-kappaB and a Rho/qROCK/p38/NF-kappaB pathway, respectively
Wood et al., J Biol Chem 1995
(Melanoma) :
Constitutive and cytokine induced expression of the
melanoma growth stimulatory activity/GRO alpha gene
requires both
NF-kappa B and novel constitutive factors
Luan et al., J Leukoc Biol 1997
(Disease Progression...) :
We propose that this endogenous nuclear
NF-kappaB , working in concert with the 115-kDa IUR binding factor,
promotes constitutive expression of
MGSA/GRO genes