Gene interactions and pathways from curated databases and text-mining

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BRCA1 — CYP19A1

Text-mined interactions from Literome

Lu et al., J Clin Endocrinol Metab 2006 (Breast Neoplasms...) : BRCA1 negatively regulates the cancer associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells ... Reduction of BRCA1 in BAFs and in MCF7 and SKBR3 malignant breast epithelial cells using small interfering RNA ( siRNA ) or small hairpin RNA significantly increased aromatase mRNA levels and enzyme activity
Subbaramaiah et al., J Biol Chem 2008 (Breast Neoplasms...) : Activation of the aromatase promoter by PGE ( 2 ) was suppressed by overexpressing wild-type BRCA1
Chand et al., BMC cancer 2009 : Of significance is the finding that BRCA1 negatively regulates aromatase expression in vitro
Lu et al., J Steroid Biochem Mol Biol 2011 : BRCA1/BARD1 complex interacts with steroidogenic factor 1 -- A potential mechanism for regulation of aromatase expression by BRCA1