Schattenberg et al., Hepatology 2004
(MAP Kinase Signaling System) :
The effect of CYP2E1 overexpression on MAPK activation and their function in altering death responses of CYP2E1 overexpressing hepatocytes were investigated
Wang et al., Free Radic Biol Med 2009
(Drug-Induced Liver Injury...) :
These results show that chronic ethanol feeding enhances Fas induced liver injury by a mechanism associated with induction of CYP2E1 , elevated serum TNF-alpha levels, and activation of MAPK