Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Roger et al., FEBS Lett 2004 : By contrast, MRS 2179 ( 10 microM ), a specific antagonist of P2Y1, a Gq-coupled ADP receptor, did not affect collagen induced ERK2 activation
Crosson et al., J Pharmacol Exp Ther 2004 : This activation of ERK1/2 was blocked by pretreatment with the mitogen activated protein kinase kinase inhibitor 1,4-diamino-2,3-dicyano-1,4-bis ( o-aminophenylmercapto ) butadiene ( U-0126 ) or the protein kinase C inhibitor chelerythrine chloride, but not by MRS-2179
Liu et al., Basic Res Cardiol 2010 (Myocardial Infarction...) : AMP579 induced ERK phosphorylation with an EC50 of 250 nM and this phosphorylation could be blocked by MRS1754 or PSB1115, two highly selective blockers of human A2b receptors
Tsukimoto et al., Radiat Res 2010 : The activation of ERK1/2 was blocked by suramin ( P2Y inhibitor ), MRS2578 ( P2Y(6) antagonist ) and apyrase