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DEFB1 — TNF
Text-mined interactions from Literome
Pandey et al., Int Immunopharmacol 2005
:
Bd-I inhibited production of PHA stimulated IL-2 at the protein and mRNA transcript levels and LPS
stimulated TNF-alpha production in human PBMCs ; it also blocked the activation of DNA binding of nuclear factor- ( kappa ) B and AP-1, two major transcription factors centrally involved in expression of the IL-2 and IL-2R gene, which are necessary for T cell activation and proliferation
Motzkus et al., FASEB J 2006
(Sepsis) :
Moreover,
DEFB123 prevented LPS induced
tumor necrosis factor (TNF)-alpha secretion in a murine monocyte cell line ( RAW264.7 )
Yu et al., J Biol Chem 2013
(Inflammation...) :
Interestingly,
DEFB114 demonstrated novel LPS binding activity in vitro and
inhibited TNF-a release in RAW264.7 cultures through the inhibition of MAPK p42/44 when challenged with LPS