Gene interactions and pathways from curated databases and text-mining

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DEFB103B — TNF

Text-mined interactions from Literome

Fahlgren et al., Clin Exp Immunol 2004 (Colitis, Ulcerative...) : Interferon (IFN)-gamma, but not tumour necrosis factor (TNF)-alpha or IL-1beta, augmented hBD-3 mRNA expression
Vankeerberghen et al., J Periodontol 2005 (Periodontal Pocket) : In addition to the published observations ( PMA induces hBD-2 and -4 ; TNF-alpha induces hBD-2 and -3 ), it was found that PMA can upregulate hBD-1 and hBD-3, whereas TNF-alpha can induce hBD-4
Albanesi et al., J Immunol 2007 : We demonstrate here that stimulation of keratinocytes with TNF-alpha/IFN-gamma induces HBD-2 and HBD-3 by activating STAT-1 and NF-kappaB signaling ... This interferes with STAT-1 and NF-kappaB signaling, thereby inhibiting TNF-alpha/IFN-gamma mediated induction of HBD-2 and HBD-3
Semple et al., Eur J Immunol 2010 (Endotoxemia...) : In addition, in the presence of LPS, hBD3 and the murine orthologue Defb14 ( but not hBD2 ), effectively inhibit TNF-alpha and IL-6 accumulation implying an anti-inflammatory function ... hBD3 also inhibits CD40/IFN-gamma stimulation of Mphi and in vivo, hBD3 significantly reduces the LPS induced TNF-alpha level in serum
Hau et al., Am J Pathol 2013 (Psoriasis) : siRNAs targeting c-Jun and STAT3 suppressed visfatin plus TNF-a induced hBD-3 production