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DEFB103B — TNF
Text-mined interactions from Literome
Fahlgren et al., Clin Exp Immunol 2004
(Colitis, Ulcerative...) :
Interferon (IFN)-gamma, but not
tumour necrosis factor (TNF)-alpha or IL-1beta,
augmented hBD-3 mRNA expression
Vankeerberghen et al., J Periodontol 2005
(Periodontal Pocket) :
In addition to the published observations ( PMA induces hBD-2 and -4 ;
TNF-alpha induces
hBD-2 and -3 ), it was found that PMA can upregulate hBD-1 and hBD-3, whereas TNF-alpha can induce hBD-4
Albanesi et al., J Immunol 2007
:
We demonstrate here that stimulation of keratinocytes with
TNF-alpha/IFN-gamma induces HBD-2 and
HBD-3 by activating STAT-1 and NF-kappaB signaling ... This interferes with STAT-1 and NF-kappaB signaling, thereby inhibiting
TNF-alpha/IFN-gamma mediated induction of HBD-2 and
HBD-3
Semple et al., Eur J Immunol 2010
(Endotoxemia...) :
In addition, in the presence of LPS,
hBD3 and the murine orthologue Defb14 ( but not hBD2 ), effectively
inhibit TNF-alpha and IL-6 accumulation implying an anti-inflammatory function ...
hBD3 also inhibits CD40/IFN-gamma stimulation of Mphi and in vivo, hBD3 significantly
reduces the LPS induced
TNF-alpha level in serum
Hau et al., Am J Pathol 2013
(Psoriasis) :
siRNAs targeting c-Jun and STAT3 suppressed visfatin plus
TNF-a induced
hBD-3 production