Gene interactions and pathways from curated databases and text-mining

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DLL3 — NOTCH4

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Ladi et al., J Cell Biol 2005 : The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
Geffers et al., J Cell Biol 2007 : Dll3 does not compensate for Dll1 ; DLL1 activates Notch in Drosophila wing discs, but DLL3 does not
Mine et al., Oncol Rep 2010 (Fibrosarcoma...) : Notch is activated by DLL and Jag presents on neighboring cells
Sugiyama et al., Biochem Biophys Res Commun 2010 : Delta1 and Delta4, but not Delta3 , exhibit filopodial protrusive activity, and this activity is independent of Notch signaling
Hoyne et al., Immunol Cell Biol 2011 : We show that Dll3 can not activate Notch when expressed in trans but like other Notch ligands it can inhibit Notch signalling when expressed in cis with the receptor
Turchi et al., Stem Cells 2013 : Mechanistically, ERK dependent induction of miR-18a* directly represses expression of DLL3 , an autocrine inhibitor of NOTCH , thus enhancing the level of activated NOTCH-1