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EDA — RELA
Text-mined interactions from Literome
Döffinger et al., Nat Genet 2001
(Ectodermal Dysplasia...) :
We also show that the ectodysplasin receptor, DL, triggers NF-kappaB through the NEMO protein, indicating that
EDA results from impaired
NF-kappaB signaling
Bal et al., Hum Mutat 2007
(Ectodermal Dysplasia 1, Anhidrotic) :
Our results confirm that
NF-kB activation is
impaired in
EDA and support the role of EDARADD DD as a downstream effector of EDAR signaling
Pispa et al., Hum Mol Genet 2008
:
Assessment of NF-kappaB activity with a transgenic reporter construct indicated that
Eda is the main
activator of
NF-kappaB signalling in developing skin appendages and surprisingly that the functional overlap of Troy and Eda signalling pathways is mediated by NF-kappaB independent pathways