Gene interactions and pathways from curated databases and text-mining

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EDA — RELA

Text-mined interactions from Literome

Döffinger et al., Nat Genet 2001 (Ectodermal Dysplasia...) : We also show that the ectodysplasin receptor, DL, triggers NF-kappaB through the NEMO protein, indicating that EDA results from impaired NF-kappaB signaling
Bal et al., Hum Mutat 2007 (Ectodermal Dysplasia 1, Anhidrotic) : Our results confirm that NF-kB activation is impaired in EDA and support the role of EDARADD DD as a downstream effector of EDAR signaling
Pispa et al., Hum Mol Genet 2008 : Assessment of NF-kappaB activity with a transgenic reporter construct indicated that Eda is the main activator of NF-kappaB signalling in developing skin appendages and surprisingly that the functional overlap of Troy and Eda signalling pathways is mediated by NF-kappaB independent pathways