Gene interactions and pathways from curated databases and text-mining

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EDN2 — MAPK9

Text-mined interactions from Literome

Nilsson et al., Eur J Pharmacol 2008 (Cardiovascular Diseases) : We hypothesize that protein kinase C ( PKC ) and mitogen activated kinases ( MAPK ) are involved in the regulation of endothelin receptors
Eriksson et al., J Ethnopharmacol 2008 : We also demonstrate that Panax ginseng, endothelin-3 (ET-3) and alpha-melanocyte stimulating hormone ( MSH ) stimulate an activation of mitogen activated protein kinase ( MAPK )
Nilsson et al., BMC cardiovascular disorders 2008 : The involvement of PKC and MAPK in the endothelin receptor regulation was examined by culture in the presence of antagonists
Chen et al., BMC cell biology 2009 : Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells
Sandhu et al., Toxicol Appl Pharmacol 2010 : The present study was designed to examine if lipid-soluble ( dimethyl sulfoxide-soluble ) cigarette smoke particles ( DSP ) induces upregulation of contractile endothelin type B ( ET ( B ) ) receptors in rat cerebral arteries and if activation of mitogen activated protein kinase ( MAPK ) and nuclear factor-kappaB ( NF-?B ) mediate the upregulation of contractile endothelin receptors in the cerebral arteries
Zhang et al., TheScientificWorldJournal 2010 (Cardiovascular Diseases...) : Up-regulation of endothelin receptors induced by cigarette smoke -- involvement of MAPK in vascular and airway hyper-reactivity
Lazou et al., Circ Res 1994 : In isolated myocytes, endothelin 1 ( 100 nmol/L for 5 minutes ) also stimulated MAPK , but stimulation by norepinephrine or isoproterenol was difficult to detect
Sugimoto et al., Biochem Biophys Res Commun 1993 : In cultured rat glomerular mesangial cells, endothelin-1 (ET-1) activated both pp 44 and pp 42 mitogen activated protein ( MAP ) kinases
Jones et al., Life Sci 1996 : Effects of endothelin on mitogen activated protein kinase activity and protein synthesis in isolated adult feline cardiac myocytes
Scott et al., Biochem J 1996 : In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and endothelin ( Et-1 ) stimulate sustained and comparable activation of mitogen activated protein kinase ( MAP kinase ) but display very different mitogenic efficacies, with PDGF inducing 50 times more DNA synthesis than Et-1