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AKT1 — EFNB1
Text-mined interactions from Literome
Minami et al., Mol Biol Cell 2011
(MAP Kinase Signaling System) :
EphrinA1-Fc suppressed IGF-I induced activation of Ras and ERK1/2, but not that of AKT, in C2C12 myoblasts, whereas
ephrinB1-Fc affected neither ERK1/2 nor
AKT activated by IGF-I
Yu et al., PloS one 2012
(Disease Models, Animal...) :
Pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented activation of spinal
AKT induced by
ephrinB1-Fc. Inhibition of spinal PI3K signaling dose-dependently prevented and reversed pain behaviors and spinal c-Fos protein expression induced by intrathecal injection of ephrinB1-Fc. Inhibition of EphBs receptors by intrathecal injection of EphB1-Fc reduced formalin induced inflammation and chronic constrictive injury induced neuropathic pain behaviors accompanied by decreased expression of spinal PI3K, p-AKT and c-Fos protein