Gene interactions and pathways from curated databases and text-mining

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EGF — IL6

Text-mined interactions from Literome

Tokunou et al., Arterioscler Thromb Vasc Biol 2001 : Pharmacological inhibition of extracellular signal regulated protein kinase ( ERK ), p38 mitogen activated protein kinase ( MAPK ), or epidermal growth factor receptor (EGF-R) suppressed the thrombin induced IL-6 expression
Deaciuc et al., Alcohol Clin Exp Res 2002 (Liver Diseases, Alcoholic) : EGF did not affect liver mRNA expression of TNF-alpha, IL-1beta, IL-6 , and IL-10, which suggested that these cytokines were not involved in EGF protective effect
Halpern et al., J Pediatr Gastroenterol Nutr 2003 (Disease Models, Animal...) : We have shown in previous studies that proinflammatory interleukin-18 and interleukin-12 are up-regulated in the ileum of rats with experimental NEC and that epidermal growth factor (EGF) reduces the development of disease
Le et al., J Exp Med 1991 : Regulation of cytokine production in the human thymus : epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta, and IL-6 in human thymic epithelial cells at a post-transcriptional level
Yang et al., Exp Eye Res 2010 : Neither EGF nor WIN induced any increases in IL-6 and IL-8 release
Alberti et al., Oncogene 2012 (Neoplasms, Glandular and Epithelial...) : A significant reduction of EGF stimulated IL-6/PAI-1 secretion was also obtained with the NFkB inhibitor dehydroxymethylepoxyquinomicin
Jones et al., Acta Endocrinol (Copenh) 1993 (Adenoma...) : Interleukin-1 (IL-1) stimulated IL-6 release after a 24-h incubation period in five of the seven IL-6 secreting adenoma cultures and in all seven after 72 h. Tumour necrosis factor, interferon-gamma and epidermal growth factor did not significantly affect IL-6 secretion
Wu et al., J Biol Chem 1996 : In contrast, NGF and EGF , in the presence or absence of IL-6 , cause mobility shifts of Stat3 that are consistent with serine phosphorylations
Schluns et al., J Immunol 1997 : TGF-beta differentially modulates epidermal growth factor mediated increases in leukemia-inhibitory factor, IL-6 , IL-1 alpha, and IL-1 beta in human thymic epithelial cells ... TGF-beta plus EGF did not affect transcription of LIF and IL-6 genes ; this suggests that the increases in the steady state levels of cytokine mRNA were mediated post-transcriptionally, most likely at the level of mRNA stability
Murthy et al., J Lipid Res 1997 : The results suggest that, in CaCo-2 cells, IL-6 causes the release of EGF or an EGF-like molecule