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EGF — NEUROD6

Text-mined interactions from Literome

Kusumoto et al., In Vitro Cell Dev Biol Anim 2009 : Maximum mitogenic stimulation with 50 ng/mL EGF blocked the BMP-4 effect on neuronal differentiation , but did not block TGF-beta induced expression of markers of the astrocytic lineage
den Hertog et al., Cell Growth Differ 1991 : Interestingly, neuronal differentiation is induced in these cells in response to EGF under culture conditions resembling those during early preimplantation embryogenesis
Teng et al., J Biol Chem 1995 : Nerve growth factor (NGF) and epidermal growth factor (EGF) elicit contrasting actions on PC12 pheochromocytoma cells ; NGF causes neuronal differentiation , and EGF induces proliferation
Traverse et al., Curr Biol 1994 : EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
Yamada et al., Neurochem Res 1996 : EGF induced sustained tyrosine phosphorylation and decreased rate of down-regulation of EGF receptor in PC12h-R cells which show neuronal differentiation in response to EGF ... We examined the mechanism by which EGF induced the neuronal differentiation in PC12h-R cells ... The EGF induced neuronal differentiation of PC12h-R cells was not blocked by K252a, whereas that induced by NGF was ... EGF induced sustained tyrosine phosphorylation of the EGF receptor in PC12h-R cells, but not in the parent PC12h cells, which do not show neuronal differentiation in response to EGF ... These findings suggested that the EGF induced neuronal differentiation of PC12h-R cells is due to the sustained activation of the EGF receptor, resulting from the decreased down-regulation of the EGF receptor and that the duration of the receptor tyrosine kinase activity determines the cellular responses of PC12 cells