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EGR1 — VEGFA
Text-mined interactions from Literome
Houston et al., Biochem Biophys Res Commun 2001
:
NAB2 blocks Egr-1 activation of the tissue factor ( TF ) promoter,
Egr-1 stimulated production of PDGF-AB, HGF, TGFbeta(1), and
VEGF and the endogenous expression of PDGF-AB and TGFbeta(1)
Szabó et al., J Physiol Paris 2001
:
This study aimed to determine whether indomethacin ( IND ) and/or the selective COX-2 inhibitor, NS-398, interfere with
egr-1 gene expression in human microvascular endothelial cells ( HMVEC ) in
response to
vascular endothelial growth factor ( VEGF ) stimulation ... IND pre-treatment significantly inhibited
VEGF induced
Egr-1 mRNA expression by 29+/-4 % ( P < 0.01 ) and protein expression by 41+/-8 % ( P < 0.05 )
Sassa et al., Graefes Arch Clin Exp Ophthalmol 2002
:
VEGF activated transcription factor
Egr-1 within 60 min. Inactivation of Egr-1 by PD98059 resulted in the prohibition of VEGF induced TF gene expression
Tarnawski et al., J Mol Med (Berl) 2003
(Neoplasms...) :
Some of these mechanisms include : inhibition of mitogen activated protein ( Erk2 ) kinase activity ; suppression of cell cycle proteins ;
inhibition of early growth response (
Egr-1 ) gene activation ; interference with hypoxia inducible factor 1 and
VEGF gene activation ; increased production of the angiogenesis inhibitor, endostatin ; inhibition of endothelial cell proliferation, migration, and spreading ; and induction of endothelial apoptosis
Goldhar et al., Mol Cell Endocrinol 2005
:
Our results indicate that PRL
induces VEGF expression through
Egr-1 , and implicates VEGF as an intermediary of PRL regulated angiogenesis
Worden et al., Cancer Res 2005
(Carcinoma, Squamous Cell...) :
In the present study, we investigated the potential
role of HGF induced
Egr-1 in expression of PDGF,
VEGF , and IL-8 ... Consistent with this, expression of PDGFA and
VEGF but not IL-8 showed corresponding differences with Egr-1 expression in HNSCC tumor specimens and were strongly
suppressed by transfection of
Egr-1-antisense or small interference RNA ( siRNA ) oligonucleotides ... We conclude that the HGF induced activation of transcription factor
Egr-1 by MEK1/2- and PKC dependent mechanisms differentially
contributes to expression of PDGF and
VEGF , which are important angiogenesis factors and targets for HNSCC therapy
Shimoyamada et al., Am J Pathol 2010
(Adenocarcinoma...) :
We demonstrate here that
early growth response-1 (EGR-1) , which is induced by the extracellular signal regulated kinase ( ERK ) pathway activation,
activates VEGF-A in lung cancer cells ... Hypoxic culture, siRNA experiment, luciferase assays, chromatin immunoprecipitation, electrophoretic mobility shift assays, and quantitative RT-PCR using EGR-1-inducible lung cancer cells demonstrated that
EGR-1 binds to the proximal region of the VEGF-A promoter,
activates VEGF-A expression, and enhances hypoxia inducible factor 1alpha ( HIF-1alpha ) -mediated VEGF-A expression
Kim et al., Cell Physiol Biochem 2011
:
Transfection of
Egr-1 or Sp-1 expression vector
increased VEGF luciferase activity in VEGF-Luc transfected cells, and this was inhibited by transfection with wt p53