Gene interactions and pathways from curated databases and text-mining

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EGR2 — JUN

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Levkovitz et al., J Neurosci 2001 : Furthermore, the Egr inhibitor blocks the ability of MEKK1 [ mitogen activated protein kinase ( MAPK ) kinase kinase 1 ], an upstream kinase capable of stimulating the JNK ( c-Jun N-terminal protein kinase ) -c-Jun pathway, to induce apoptosis and activate c-Jun
Levkovitz et al., J Neurosci 2002 : A dominant negative Egr inhibitor blocks nerve growth factor induced neurite outgrowth by suppressing c-Jun activation : role of an Egr/c-Jun complex
Parkinson et al., J Cell Biol 2004 : Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death
Mirsky et al., J Peripher Nerv Syst 2008 (Demyelinating Diseases) : Likewise, the transcription factor c-Jun is required for Schwann cell proliferation and death and is down-regulated by Krox-20 on myelination
Song et al., Neuroreport 2012 : However, our data show that neither suppressing Egr activity using a dominant negative mutant nor specifically silencing Egr-1 using small interfering RNA inhibited the activation and expression of c-Jun after activity deprivation in cerebellar granule neurons