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EPHA2 — SRC

Pathways - manually collected, often from reviews:

• NCI Pathway Database EPHA2 forward signaling: Ephrin A1/EPHA2/Src complex (EFNA1-EPHA2-SRC) → Src (SRC) (modification, collaborate) Fang et al., J Cell Sci 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EPHA2 forward signaling: Ephrin A1/EPHA2/Src complex (EFNA1-EPHA2-SRC) → Ephrin A1/EPHA2 complex (EFNA1-EPHA2) (modification, collaborate)
  Fang et al., J Cell Sci 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EPHA2 forward signaling: Src (SRC) → Ephrin A1/EPHA2 complex (EFNA1-EPHA2) (modification, collaborate)
  Fang et al., J Cell Sci 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EPHA forward signaling: Ephrin A1/EPHA1-4 complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
  Walker-Daniels et al., Mol Cancer Res 2002, Sharfe et al., J Immunol 2003
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHA forward signaling: Ephrin A1/EPHA1-4 complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Shamah et al., Cell 2001, Sahin et al., Neuron 2005
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: EPHA2 → SRC (reaction) Marignani et al., J Cell Biol 2001, Marston et al., Nat Cell Biol 2003, Cowan et al., Neuron 2005
• Reactome Reaction: EPHA2 → SRC (indirect_complex)
• Reactome Reaction: EPHA2 → SRC (direct_complex)

Text-mined interactions from Literome

Chakraborty et al., Proc Natl Acad Sci U S A 2012 : EphA2 associates with c-Cbl-myosin IIA and augmented KSHV induced Src and PI3-K signals in LRs, leading to bleb formation and macropinocytosis of KSHV
Tawadros et al., Br J Cancer 2012 (Neoplasm Metastasis...) : Arachidonic acid induced a rapid increase of EphA2 Akt-dependent/ligand independent activation, while knockdown of the EphrinA1 ligand decreased AA induced transendothelial migration, with an associated decrease in Src and FAK activity
Sugiyama et al., J Cell Biol 2013 (Breast Neoplasms...) : This cleavage, coupled with EphA2 dependent Src activation, triggered intracellular EphA2 translocation, as well as an increase in RhoA activity and cell junction disassembly, which suggests an overall repulsive effect between cells