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AKT3 — EPO

Text-mined interactions from Literome

Tramontano et al., Biochem Biophys Res Commun 2003 (Anoxia...) : In the NRVM, EPO increased the activity of Akt
Digicaylioglu et al., Proc Natl Acad Sci U S A 2004 : EPO+IGF-I synergistically activated Akt ( protein kinase B ), a downstream target of PI3-K, and prevented dephosphorylation of Akt
Sekiguchi et al., Diabetes Res Clin Pract 2004 : Furthermore, Epo induced phosphorylation of Akt in dose dependent manner
Hanlon et al., FASEB J 2005 (Myocardial Infarction...) : Perfusion with the phosphatidylinositol 3-kinase (PI3K) inhibitors LY294002 or wortmannin just before and concomitant with EPO treatment attenuated EPO induced phosphorylation of the PI3K substrate Akt but had no effect on EPO mediated cardioprotection
Sekiguchi et al., Biochem Biophys Res Commun 2005 : Erythropoietin stimulated Akt phosphorylation in a dose dependent manner ( 1-100 U/ml )
Kadri et al., Mol Cell Biol 2005 : We report here that erythropoietin regulates the transcription of the TIMP-1 gene upon binding to its receptor in erythroid cells by triggering the activation of phosphatidylinositol 3-kinase (PI3K)/Akt
Um et al., J Biol Chem 2006 (Neuroblastoma) : Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways
Hardee et al., Mol Cancer Ther 2006 (Adenocarcinoma...) : We showed that systemic recombinant erythropoietin treatment of rats bearing R3230 mammary carcinomas induced an increase in phospho-Akt levels within tumor cells
Urao et al., Circ Res 2006 (Hyperplasia...) : Epo induced Akt/eNOS phosphorylation and NO synthesis on EPCs and exerted an antiapoptotic action on wire injured arteries
Kumar et al., Melanoma Res 2006 (Anoxia...) : Epo increased Akt kinase activity, which was abrogated by co-treatment with LY294002, a specific blocker of phosphoinositide 3-kinase
Wu et al., Eur J Pharmacol 2007 (Neurotoxicity Syndromes) : In addition, the downstream effector of PI3K, Akt, was activated by erythropoietin , and Akt activation was inhibited by LY 294002
Yin et al., Int J Oncol 2007 (Brain Neoplasms...) : Furthermore, EPO increased the phosphorylation of AKT through the PI3K pathway in the glioma cells
Kobayashi et al., Clin Exp Pharmacol Physiol 2008 (Myocardial Infarction...) : Erythropoietin increased phospho-Akt in the mitochondria and induced complex formation of Akt with adenine nucleotide translocase ( ANT ), a major subunit of mPTP, upon reperfusion
Ransome et al., Mol Cell Neurosci 2008 : EPO stimulated the phosphorylation of Akt at serine-473 and co-incubation of the Akt/PI-3 kinase pathway inhibitor LY294002 with EPO abolished its effects on Akt phosphorylation and axonal growth
Missiroli et al., Int J Biochem Cell Biol 2009 (Leukemia, Erythroblastic, Acute) : In this work we show that erythropoietin stimulation of K562 cells can induce nuclear translocation of active Akt , a downstream molecule of the phosphatidyl-inositol 3-kinase signaling pathway ... Akt shows a peak of activity in whole cell homogenates at earlier stage when compared to the nucleus, which shows a peak delayed of 10 min. Akt increases its intranuclear amount and activity rapidly and transiently in response to EPO
Fukumoto et al., Cell Signal 2009 (Leukemia, Erythroblastic, Acute) : EPO induced activation of Erk1/2 but not of Akt was significantly suppressed in F-36P-Gab1-siRNA cells compared with mock transfected F-36P cells
Miki et al., Diabetes 2009 (Body Weight...) : However, neither phosphorylation of Akt and GSK-3beta nor infarct size limitation was induced by EPO in OLETF rats
Wen et al., Zhonghua Xin Xue Guan Bing Za Zhi 2009 : EPO also activated Akt and enhanced the expression of eNOS and its phosphorylation ( all P < 0.05 ), increased the NO production ( P < 0.01 )
Laubach et al., Exp Hematol 2009 (Polycythemia Vera) : EPO induced AKT phosphorylation was observed in PV but not normal erythroblasts, an effect associated with apoptosis resistance in PV erythroblasts
Wang et al., Nan Fang Yi Ke Da Xue Xue Bao 2010 (Status Epilepticus) : [ Effect of recombinant human erythropoietin on hippocampal p-Akt and caspase-9 expressions in rats with status epilepticus and the mechanism ] ... To observe the effect of recombinant human erythropoietin ( rhuEPO ) on p-Akt and caspase-9 expressions in the hippocampus of rats with status epilepticus ( SE ) and explore the neuroprotective mechanism of rhuEPO
Perna et al., Blood 2010 (MAP Kinase Signaling System...) : Indeed, L3MBTL1 knockdown enhanced the sensitivity of hematopoietic stem/progenitor cells to erythropoietin (Epo), with increased Epo induced phosphorylation of STAT5, AKT , and MAPK as well as detectable phosphorylation in the absence of Epo
Follo et al., Leukemia 2012 (Myelodysplastic Syndromes) : Moreover, in normal CD34+ cells induced to erythroid differentiation, PI-PLCbeta1 overexpression abrogated both EPO induced Akt phosphorylation and beta-Globin expression
Coldewey et al., Kidney Int 2013 : In the kidneys of endotoxemic wild-type mice, EPO enhanced the phosphorylation of Akt , glycogen synthase kinase-3ß, and endothelial nitric oxide synthase, and inhibited the activation of nuclear factor-?B
Hu et al., Kidney Int 2013 : Here we found in rat kidney and in a rat renal tubular epithelial cell line ( NRK cells ) EpoR transcript and antigen, and EpoR activity signified as EPo induced phosphorylation of Jak2, ErK, Akt , and Stat5 indicating the presence of functional EpoR
Sun et al., PloS one 2013 : Our results show that baicalein induced Epo and VEGF expression in a HIF1a- and PI3K/Akt dependent manner in neurons