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ERBB2 — SRC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SRC → ERBB2 (increases, SRC Activity)
  Evidence: This study establishes that HER2/HRG signaling selectively upregulates Tyr phosphorylation of c-Src at Tyr-215 located within the SH2 domain, increases c-Src kinase activity and selectively upregulates Tyr phosphorylation of FAK at Tyr-861. HER2-overexpressing tumors showed increased levels of c-Src phosphorylation at Tyr-215. These findings suggest that HER2/HRG influence metastasis of breast cancer cells through a novel signaling pathway involving phosphorylation of FAK tyrosine 861 via activa...
• Reactome Reaction: ERBB2 → SRC (reaction) Xu et al., Mol Cell Biol 2007
• WikiPathways Signaling Pathways in Glioblastoma: IGF1R/ERBB3/FGFR1/PDGFRA/PDGFRB/ERBB2/EGFR/FGFR2/MET → SRC (mim-stimulation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SRC — ERBB2 (physical association, affinity chromatography technology) Liang et al., Cancer Cell 2010*
• IRef Biogrid Interaction: SRC — ERBB2 (direct interaction, pull down) Ren et al., J Biol Chem 2002
• IRef Biogrid Interaction: SRC — ERBB2 (physical association, affinity chromatography technology) Li et al., Cancer Res 2007*
• IRef Hprd Interaction: SRC — ERBB2 (in vivo) Muthuswamy et al., Oncogene 1995*
• IRef Intact Interaction: Complex of 19 proteins (association, anti bait coimmunoprecipitation) Hawthorne et al., Mol Cancer Res 2009*
• IRef Intact Interaction: Complex of ERBB2-SRC-SRC-JAK2-ERBB2-JAK2 (association, anti bait coimmunoprecipitation) Liang et al., Cancer Cell 2010*
• IRef Intact Interaction: Complex of SRC-ERBB2-PIK3R1-ERBB3 (association, anti bait coimmunoprecipitation) Liang et al., Cancer Cell 2010*
• IRef Intact Interaction: ERBB2 — SRC (association, coimmunoprecipitation) Ren et al., J Biol Chem 2002
• IRef Intact Interaction: ERBB2 — SRC (physical association, anti bait coimmunoprecipitation) Liang et al., Cancer Cell 2010*
• IRef Ophid Interaction: ERBB2 — SRC (aggregation, confirmational text mining) Jones et al., Nature 2006
• IRef Ophid Interaction: ERBB2 — SRC (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: ERBB2 — SRC (aggregation, confirmational text mining) Muthuswamy et al., Oncogene 1995*

Text-mined interactions from Literome

Kim et al., J Biol Chem 2002 (Breast Neoplasms) : Our previous studies demonstrated that Csk homologous kinase (CHK) acts as a negative growth regulator of human breast cancer through inhibition of ErbB-2/neu mediated Src family kinase activity ( Bougeret, C., Jiang, S., Keydar, I., and Avraham, H. ( 2001 ) J. Biol. Chem. 276, 33711-33720
Tan et al., Cancer Res 2005 (Breast Neoplasms...) : ErbB2 promotes Src synthesis and stability : novel mechanisms of Src activation that confer breast cancer metastasis ... Our studies revealed two novel mechanisms that are involved in Src protein up-regulation and activation by ErbB2 : ( a ) ErbB2 increased Src translation through activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway and ( b ) ErbB2 increased Src stability most likely through the inhibition of the calpain protease ... Together, activation of ErbB2 and downstream signaling pathways can lead to increased Src protein synthesis and decreased Src protein degradation resulting in Src up-regulation and activation, which play critical roles in ErbB2 mediated breast cancer invasion and metastasis
Xu et al., Mol Cell Biol 2007 : Loss of Hsp90 association up-regulates Src dependent ErbB2 activity ... We show further that Tyr877 phosphorylation is mediated by Src and that it is necessary for the enhanced kinase activity of ErbB2
Ishizawar et al., Oncogene 2007 (Breast Neoplasms) : This paper investigates the role of c-Src in modulating the physical and functional interaction between ErbB2 and ErbB3, two family members that preferentially associate with one another and together exhibit high oncogenic potential ... In contrast to previous studies that defined a role for c-Src downstream of ErbB2/ErbB3, the current work suggests an upstream mechanism, whereby c-Src enhances ErbB2/ErbB3 signaling and biological functions by positively modulating the association between ErbB2 and ErbB3
Gratio et al., Int J Cancer 2009 (Calcium Signaling...) : Finally, the Src inhibitor PP2 abrogated ErbB-2 and ERK phosphorylation and HT29 cell proliferation, suggesting the essential role of Src activity in PAR4 induced phosphorylation of ErbB-2
Houshmandi et al., Mol Cell Biol 2009 : Next, we demonstrate that Src activation results from merlin regulation of ErbB2 activation and that genetic or pharmacologic ErbB2 inhibition reduces Nf2 ( -/- ) glial cell Src/Src effector activation and proliferation to wild-type levels ... Lastly, we show that merlin competes with Src for direct binding to ErbB2 and present a novel molecular mechanism for merlin regulation of ErbB2 dependent Src signaling and growth control
Arias-Romero et al., Cancer Res 2009 (Cell Transformation, Neoplastic) : Activation of ErbB2 , but not ErbB1, increases PTP1B expression, and increased expression of PTP1B activates Src and induces a Src dependent transformed phenotype
Rivas et al., Breast Cancer Res Treat 2010 (Breast Neoplasms...) : ErbB-2 phosphorylation at Tyr877 residue was mediated by TNFalpha induced c-Src activation
Sheffield et al., Biochem Biophys Res Commun 1998 : C-Src activation by ErbB2 leads to attachment independent growth of human breast epithelial cells