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EPHB2 — ESR1

Text-mined interactions from Literome

Singh et al., J Neurosci 2000 (MAP Kinase Signaling System) : Interestingly, the transcriptionally inactive stereoisomer 17alpha-estradiol did elicit a strong induction of ERK phosphorylation, which, together with the inability of the ER-alpha- and ER-beta-selective ligands to elicit ERK phosphorylation, and of ICI 182,780 to block the actions of estradiol in ERKO cultures, supports the hypothesis that a novel, estradiol-sensitive and ICI-insensitive estrogen receptor may mediate 17beta-estradiol induced activation of ERK in the brain
de Jager et al., J Biol Chem 2001 : Egr-1 mRNA and protein were rapidly and strongly induced by estrogen in an estrogen receptor dependent manner via the extracellular signal regulated kinase, ERK1/2
Chieffi et al., Int J Oncol 2003 (Prostatic Neoplasms) : 17beta-estradiol induced activation of ERK1/2 through endogenous androgen receptor-estradiol receptor alpha-Src complex in human prostate cells
Jessop et al., J Bone Miner Res 2004 (Mechanotransduction, Cellular) : This response is replicated in vitro and involves ERK mediated activation of the estrogen receptor (ER) alpha and upregulation of estrogen response element activity
Bourguignon et al., J Biol Chem 2005 (Disease Progression...) : The activated ERK2 then increased the phosphorylation of both Elk-1 and estrogen receptor-alpha (ER alpha) , resulting in Elk-1- and estrogen-responsive element mediated transcriptional up-regulation ... Down-regulation of IQGAP1 ( by treating cells with IQGAP1-specific small interfering RNAs ) not only blocked IQGAP1 association with CD44, Cdc42, F-actin, and ERK2 but also abrogated HA-CD44 induced cytoskeletal function, ERK2 signaling ( e.g. ERK2 phosphorylation/activity, ERK2 mediated Elk-1/ER alpha phosphorylation, and Elk-1/ER alpha-specific transcriptional activation ), and tumor cell migration
Kronblad et al., Oncogene 2005 (Breast Neoplasms) : Hypoxia further caused transcriptional downregulation of ERalpha via activation of ERK1/2 in cell lines and, importantly, MEK1/2 inhibitors ( U0126 or PD184352 ) or ERK1/2 suppression by siRNA partially restored the ERalpha expression
Penolazzi et al., Apoptosis 2008 (Bone Resorption) : The resistance to apoptosis seems to be not correlated with NF-kB, NFATc1, or ERalpha expression level, or with the activation of ERK and Akt proteins
Di et al., Hum Reprod 2008 (Leiomyoma...) : Additionally, extracellular regulated kinase (ERK) , Src homology/collagen (Shc) and ER alpha were transiently activated, and interactions between ER alpha and IGF-I receptor (IGF-IR) were rapidly induced by genistein in LM cells ... ER alpha is involved in the transient activation of ERK/mitogen activated protein kinase ( MAPK ) by genistein via its early association with IGF-IR, leading to hyper-responsiveness of LM cells and confirming that ER signaling is enhanced by activation of ERK/MAPK in LM cells
Dominguez et al., J Neurosci 2009 (Gangliosidosis, GM1) : These results demonstrate that E2-mediated neuroprotection and ERK activation involve ERalpha activation of G-protein- and beta-arrestin mediated mechanisms
Lin et al., Reproductive biology and endocrinology : RB&E 2009 (Carcinoma...) : Testosterone induces ERK and Akt phosphorylation via the membrane initiated signaling pathways mediated by ER-alpha36 , suggesting a possible involvement of ER-alpha 36 in testosterone carcinogenesis
Kang et al., Mol Endocrinol 2010 : G1 induced activities mediated by ER-alpha36, such as transcription activation activity of a VP16-ER-alpha36 fusion protein and activation of the MAPK/ERK1/2 in ER-alpha36 expressing cells
Vicent et al., Mol Endocrinol 2010 : Rapid activation of Erk by progestins via an interaction of the progesterone receptor (PR) with the estrogen receptor is critical for transcriptional activation of the mouse mammary tumor virus ( MMTV ) promoter and other progesterone target genes
Jain et al., Nanomedicine (Lond) 2012 (MAP Kinase Signaling System) : Our findings demonstrate that in vitro cadmium containing QDs induce cellular proliferation, estrogen receptor a activation , and biphasic phosphorylation of AKT and ERK1/2 , comparable with 17ß-estradiol
Watson et al., Steroids 2012 (MAP Kinase Signaling System...) : Estrogen- and xenoestrogen induced ERK signaling in pituitary tumor cells involves estrogen receptor-a interactions with G protein-ai and caveolin I
Hashimoto et al., Evidence-based complementary and alternative medicine : eCAM 2012 : These results suggest that ginsenoside Rb1 protects PC12 cells from caspase-3 dependent apoptosis through stimulation of estrogen receptor with consequent activation of ERK1/2 and Akt and inhibition of SAPK/JNK and p38