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ESR1 — SRC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of BCAR1-ESR1-PIK3R1-SRC → SRC (directlyIncreases, BCAR1/ESR1/PIK3R1/SRC Activity) Cabodi et al., J Cell Sci 2004
  Evidence: We show that in the human breast carcinoma T47D cells, upon estrogen treatment, p130Cas rapidly and transiently associates with the estrogen receptor alpha in a multi-molecular complex containing the c-Src kinase and the p85 subunit of PI 3-kinase. Association of p130Cas with the estrogen receptor alpha occurs within 3 minutes of estrogen treatment and is dependent on c-Src kinase activation. Transient overexpression of p130Cas in T47D cells increases estrogen-dependent Src kinase and Erk1/2 MAP...
• OpenBEL Selventa BEL large corpus: Complex of BCAR1-ESR1-PIK3R1-SRC (increases) Cabodi et al., J Cell Sci 2004
  Evidence: We show that in the human breast carcinoma T47D cells, upon estrogen treatment, p130Cas rapidly and transiently associates with the estrogen receptor alpha in a multi-molecular complex containing the c-Src kinase and the p85 subunit of PI 3-kinase. Association of p130Cas with the estrogen receptor alpha occurs within 3 minutes of estrogen treatment and is dependent on c-Src kinase activation. Transient overexpression of p130Cas in T47D cells increases estrogen-dependent Src kinase and Erk1/2 MAP...
• BioCarta pelp1 modulation of estrogen receptor activity: SRC → Estrogen/ER alpha/PELP1 complex (ESR1-PELP1) (modification, collaborate)
  
• BioCarta pelp1 modulation of estrogen receptor activity: SRC → Estrogen/ER alpha/PELP1/SRC complex (ESR1-PELP1-SRC) (modification, collaborate)
  
• BioCarta pelp1 modulation of estrogen receptor activity: Estrogen/ER alpha/PELP1 complex (ESR1-PELP1) → Estrogen/ER alpha/PELP1/SRC complex (ESR1-PELP1-SRC) (modification, collaborate)
  
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC) → E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1) (modification, collaborate)
  Song et al., Mol Endocrinol 2002, Song et al., Proc Natl Acad Sci U S A 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC) → p52 SHC (SHC1) (modification, collaborate) Song et al., Mol Endocrinol 2002, Song et al., Proc Natl Acad Sci U S A 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1) → p52 SHC (SHC1) (modification, collaborate) Song et al., Mol Endocrinol 2002, Song et al., Proc Natl Acad Sci U S A 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: IGF1 (IGF1) → E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1) (modification, collaborate)
  Kahlert et al., J Biol Chem 2000, Song et al., Proc Natl Acad Sci U S A 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1) → IGF-1R heterotetramer complex (IGF1R) (modification, activates)
  Kahlert et al., J Biol Chem 2000, Song et al., Proc Natl Acad Sci U S A 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1) → IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1) (modification, activates)
  Kahlert et al., J Biol Chem 2000, Song et al., Proc Natl Acad Sci U S A 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC) → E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1) (modification, collaborate)
  Simoncini et al., Nature 2000, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007, Cheskis et al., Steroids 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Simoncini et al., Nature 2000, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007, Cheskis et al., Steroids 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Simoncini et al., Nature 2000, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007, Cheskis et al., Steroids 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: None → E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1) (modification, activates)
  Haynes et al., Circ Res 2000, Hisamoto et al., J Biol Chem 2001, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007
  Evidence: assay
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1) → AKT1 (AKT1) (modification, activates) Haynes et al., Circ Res 2000, Hisamoto et al., J Biol Chem 2001, Haynes et al., J Biol Chem 2003, Greger et al., Mol Cell Biol 2007
  Evidence: assay
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC) → E2/ER alpha (dimer)/PELP1/Src/p130 Cas complex (ESR1-PELP1-SRC-BCAR1) (modification, collaborate)
  Cabodi et al., J Cell Sci 2004
  Evidence: physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC) → p130 Cas (BCAR1) (modification, collaborate) Cabodi et al., J Cell Sci 2004
  Evidence: physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/p130 Cas complex (ESR1-PELP1-SRC-BCAR1) → p130 Cas (BCAR1) (modification, collaborate) Cabodi et al., J Cell Sci 2004
  Evidence: physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: None → E2/ER alpha (dimer)/PELP1/Src/PI3K complex (ESR1-PELP1-SRC-PIK3CA-PIK3R1) (modification, collaborate)
  Simoncini et al., Nature 2000, Haynes et al., J Biol Chem 2003
  Evidence: mutant phenotype, assay
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1) → E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 complex (ESR1-PELP1-SRC-SHC1-GRB2-SOS1) (modification, collaborate)
  Song et al., Mol Endocrinol 2002, Kumar et al., Mol Endocrinol 2007
  Evidence: physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Song et al., Mol Endocrinol 2002, Kumar et al., Mol Endocrinol 2007
  Evidence: physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 complex (ESR1-PELP1-SRC-SHC1-GRB2-SOS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Song et al., Mol Endocrinol 2002, Kumar et al., Mol Endocrinol 2007
  Evidence: physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC) → E2/ER alpha (dimer)/PELP1 complex (ESR1-PELP1) (modification, collaborate)
  Wong et al., Proc Natl Acad Sci U S A 2002*, Haynes et al., J Biol Chem 2003, Barletta et al., Mol Endocrinol 2004*, Greger et al., Mol Cell Biol 2007, Cheskis et al., Steroids 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src complex (ESR1-PELP1-SRC) → Src (SRC) (modification, collaborate) Wong et al., Proc Natl Acad Sci U S A 2002*, Haynes et al., J Biol Chem 2003, Barletta et al., Mol Endocrinol 2004*, Greger et al., Mol Cell Biol 2007, Cheskis et al., Steroids 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1 complex (ESR1-PELP1) → Src (SRC) (modification, collaborate) Wong et al., Proc Natl Acad Sci U S A 2002*, Haynes et al., J Biol Chem 2003, Barletta et al., Mol Endocrinol 2004*, Greger et al., Mol Cell Biol 2007, Cheskis et al., Steroids 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: ER alpha/Gai/GDP/Gbeta gamma complex (ESR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-GNB1-GNG2) → Src (SRC) (modification, activates) Kumar et al., Mol Endocrinol 2007
  Evidence: mutant phenotype

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SRC — ESR1 (direct interaction, two hybrid) Jaber et al., J Mol Endocrinol 2004*
• IRef Biogrid Interaction: SRC — ESR1 (direct interaction, pull down) Kim et al., Mol Cell Biol 1999
• IRef Biogrid Interaction: SRC — ESR1 (direct interaction, two hybrid) Slentz-Kesler et al., Genomics 2000*
• IRef Biogrid Interaction: SRC — ESR1 (direct interaction, pull down) Bourdoncle et al., J Mol Biol 2005*
• IRef Biogrid Interaction: SRC — ESR1 (direct interaction, pull down) Kurtev et al., J Biol Chem 2004
• IRef Biogrid Interaction: SRC — ESR1 (physical association, affinity chromatography technology) Ku et al., J Endocrinol 2007*
• IRef Biogrid Interaction: SRC — ESR1 (direct interaction, pull down) Flajollet et al., Mol Cell Endocrinol 2007*
• IRef Biogrid Interaction: SRC — ESR1 (direct interaction, pull down) Okada et al., EMBO Rep 2008
• IRef Biogrid Interaction: SRC — ESR1 (direct interaction, two hybrid) Albers et al., Mol Cell Proteomics 2005
• IRef Biogrid Interaction: SRC — ESR1 (physical association, affinity chromatography technology) Cabodi et al., J Cell Sci 2004
• IRef Biogrid Interaction: SRC — ESR1 (direct interaction, two hybrid) Monroe et al., J Endocrinol 2003*
• IRef Biogrid Interaction: SRC — ESR1 (physical association, affinity chromatography technology) Hitosugi et al., J Biol Chem 2007*
• IRef Biogrid Interaction: SRC — ESR1 (colocalization, imaging technique) Zwart et al., EMBO J 2007*
• IRef Biogrid Interaction: SRC — ESR1 (direct interaction, two hybrid) Zwart et al., EMBO J 2007*
• IRef Biogrid Interaction: SRC — ESR1 (direct interaction, fluorescent resonance energy transfer) Zwart et al., EMBO J 2007*
• IRef Biogrid Interaction: SRC — ESR1 (physical association, affinity chromatography technology) Teo et al., Mol Cell Biol 2001*
• IRef Biogrid Interaction: SRC — ESR1 (physical association, affinity chromatography technology) Jaber et al., J Mol Endocrinol 2004*
• IRef Biogrid Interaction: SRC — ESR1 (physical association, affinity chromatography technology) Migliaccio et al., EMBO J 2000*
• MIPS CORUM p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex: p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex complex (BCAR1-ESR1-PIK3R1-SRC) Cabodi et al., J Cell Sci 2004
• IRef Corum Interaction: Complex of SRC-ESR1-PIK3R1-BCAR1 (association, anti bait coimmunoprecipitation) Cabodi et al., J Cell Sci 2004
• IRef Dip Interaction: SRC — ESR1 (physical association, anti bait coimmunoprecipitation) Li et al., Proc Natl Acad Sci U S A 2007*
• IRef Dip Interaction: Complex of SRC-NOS3-ESR1 (anti bait coimmunoprecipitation) Li et al., Proc Natl Acad Sci U S A 2007*
• IRef Hprd Interaction: SRC — ESR1 (two hybrid) Zhao et al., J Biol Chem 2003*, Kurtev et al., J Biol Chem 2004, Arnold et al., Mol Endocrinol 1995*
• IRef Hprd Interaction: SRC — ESR1 (in vitro) Zhao et al., J Biol Chem 2003*, Kurtev et al., J Biol Chem 2004, Arnold et al., Mol Endocrinol 1995*
• IRef Intact Interaction: Complex of SRC-EGFR-ESR1 (association, anti bait coimmunoprecipitation) Hitosugi et al., J Biol Chem 2007*
• IRef Intact Interaction: Complex of ESR1-SRC-PIK3R1 (association, anti bait coimmunoprecipitation) Poulard et al., EMBO Mol Med 2012*
• IRef Intact Interaction: SRC — ESR1 (physical association, anti tag coimmunoprecipitation) Zhang et al., Oncogene 2011*
• IRef Intact Interaction: SRC — ESR1 (association, pull down) Barletta et al., Mol Endocrinol 2004*
• IRef Intact Interaction: SRC — ESR1 (physical association, proximity ligation assay) Poulard et al., EMBO Mol Med 2012*

Text-mined interactions from Literome

Haynes et al., J Biol Chem 2003 : Estrogen rapidly activated c-Src inducing an estrogen receptor , c-Src, and P85 ( regulatory subunit of PI3-kinase ) complex formation
Ballaré et al., Mol Cell Biol 2003 (Breast Neoplasms...) : Progestins have been reported to activate also this pathway either via an interaction of the progesterone receptor isoform B (PRB) with ERalpha , which itself activates c-Src , or by direct interaction of PRB with the SH3 domain of c-Src
Castoria et al., Steroids 2004 : In these cells, activation of the Src- and the PI3 K-dependent pathways is simultaneous and mediated by direct interactions of the two kinases with ERalpha
Kim et al., Oncogene 2005 : Although there is strong biochemical evidence supporting a role for c-Src in ERalpha signaling, the consequence of this association is unclear at the biological level
Chu et al., J Clin Invest 2007 (Breast Neoplasms) : Src promotes estrogen dependent estrogen receptor alpha proteolysis in human breast cancer ... Inducible Src stimulated ligand activated ER alpha transcriptional activity and reduced ER alpha t(1/2) ... In both ER alpha positive and -negative cell lines, both proteasome and Src inhibitors increased ER alpha levels ... Src inhibition impaired ligand activated ER alpha ubiquitylation and increased ER alpha levels ... Oncogenic Src activation may promote not only proliferation, but also estrogen activated ER alpha loss in a subset of ER alpha negative breast cancers, altering prognosis and response to therapy
Di et al., Hum Reprod 2008 (Leiomyoma...) : Additionally, extracellular regulated kinase (ERK), Src homology/collagen (Shc) and ER alpha were transiently activated, and interactions between ER alpha and IGF-I receptor (IGF-IR) were rapidly induced by genistein in LM cells
Song et al., J Steroid Biochem Mol Biol 2010 (Breast Neoplasms) : The Src inhibitor PP2 and IGF-1-R inhibitor AG1024 greatly blocked fulvestrant induced ERalpha/IGF-1-R interaction leading to a further depletion of total cellular ERalpha induced by fulvestrant and further enhanced fulvestrant induced cell growth arrest
Hartmaier et al., Mol Endocrinol 2012 (Bone Demineralization, Pathologic...) : The coregulator steroid receptor coactivator (SRC)-1 increases transcriptional activity of the estrogen receptor ( ER ) in a number of tissues including bone
Lee et al., Eur J Pharmacol 2012 : Ugonin K-stimulated osteogenesis involves estrogen receptor dependent activation of non-classical Src signaling pathway and classical pathway