Gene interactions and pathways from curated databases and text-mining

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ESR2 — MAPK1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Improta-Brears et al., Proc Natl Acad Sci U S A 1999 (Breast Neoplasms) : In this study, we have used a pharmacological approach to dissect this novel pathway in MCF-7 breast cancer cells and have determined that in the presence of endogenous estrogen receptor , activation of MAPK by E2 is preceded by a rapid increase in cytosolic calcium
Ostrovsky et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Specific activation of MAPK by expression of an active Raf1-estrogen receptor chimera protein reduced significantly the number of myoblasts undergoing programmed cell death in the differentiation medium
Tang et al., Endocrinology 2004 (Breast Neoplasms...) : Thyroid hormone causes mitogen activated protein kinase dependent phosphorylation of the nuclear estrogen receptor
Simoncini et al., Steroids 2004 : For instance, estrogens and glucocorticoids trigger rapid vasodilatation due to rapid induction of nitric oxide synthesis in endothelial cells via the estrogen receptor dependent activation of MAPK and PI3K, leading to relevant pathophysiological consequences, in vitro and in vivo
Acconcia et al., J Cell Physiol 2005 : On the other hand, the E2-ER beta complex induced the rapid and persistent phosphorylation of p38/MAPK which, in turn, was involved in caspase-3 activation and cleavage of poly ( ADP-ribose ) polymerase, driving cells into the apoptotic cycle
Yen et al., Mol Pharmacol 2005 : Taken together, such results provide evidence that diosgenin up-regulates VEGF-A and promotes angiogenesis in preosteoblast-like cells by a hypoxia-inducible factor-1alpha dependent mechanism involving the activation of src kinase, p38 MAPK , and Akt signaling pathways via estrogen receptor
Gilad et al., J Mol Endocrinol 2007 (MAP Kinase Signaling System) : In clone A, ERbeta colocalized to membrane preparations and E2 treatment induced significant ERK 1/2 phosphorylation and enhanced VDR expression
Majidi et al., Cancer Res 2007 (Adenocarcinoma...) : ERbeta enhanced NNK induced cyclic AMP accumulation as well as Galphai mediated mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) 1/2 activation
Wang et al., Biochim Biophys Acta 2008 (Breast Neoplasms) : The estrogen receptor interacting protein HPIP increases estrogen-responsive gene expression through activation of MAPK and AKT ... Here, we report that hematopoietic PBX interacting protein ( HPIP ) interacts both with ERalpha and with ERbeta , and increases ERalpha target gene expression through activation of MAPK and AKT and enhanced ERalpha phosphorylation
Hershberger et al., J Steroid Biochem Mol Biol 2009 (Carcinoma, Non-Small-Cell Lung...) : Estrogen receptor beta (ERbeta) subtype-specific ligands increase transcription, p44/p42 mitogen activated protein kinase ( MAPK ) activation and growth in human non-small cell lung cancer cells
Yamnik et al., FEBS Lett 2010 (Breast Neoplasms) : mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor alpha serine 167 phosphorylation
Mendoza et al., J Endocrinol 2011 : The reduction in the p38 MAPK activity caused a significant increase in the expressions of estrogen receptor-a ( ERa ) and the progesterone receptor, but eliminated the expression of ERß
Kato et al., Science 1995 : Activation of the estrogen receptor through phosphorylation by mitogen activated protein kinase
Joel et al., J Biol Chem 1998 : Estradiol induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen activated protein kinase