Gene interactions and pathways from curated databases and text-mining

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ETS1 — RELA

Text-mined interactions from Literome

Lee et al., Infect Immun 2005 : Our data indicate that the increased Ets/Elk and NF-kappaB promoter activities associated with M. smegmatis infected macrophages are responsible, at least in part, for the increased TNF-alpha and NOS2 production observed in these infected cells and that ERK1/2 is required for Ets/Elk activity and full TNF-alpha production
Sangiovanni et al., PloS one 2013 : In vitro, ETs inhibited TNF-a induced NF-kB driven transcription ( IC50 : 0.67-1.73 µg/mL ) and reduced TNF-a induced NF-kB nuclear translocation ( 57 % -67 % at 2 µg/mL )
Newton et al., FEBS Lett 1997 : Furthermore, equivalent effects were observed on NF-kappaB binding to COX-2 promoter kappaB sites and activation of the Jun N-terminal kinases (JNK), p54 and p46