Gene interactions and pathways from curated databases and text-mining

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F2RL1 — MAPK14

Text-mined interactions from Literome

Hirota et al., Hum Reprod 2005 (Endometriosis...) : Activation of PAR2 stimulated the phosphorylation of all three MAPK, and inhibitors of each MAPK suppressed the PAR2 activation induced proliferation of ESC
Matsushima et al., Am J Physiol Lung Cell Mol Physiol 2006 (MAP Kinase Signaling System) : These results indicate that HAT stimulates fibroblast proliferation in bronchial airways through a PAR-2 dependent MEK-MAPK mediated pathway and that HAT is linked to airway processes involving fibroblasts
Syeda et al., J Biol Chem 2006 : PAR-1 and PAR-2 stimulation rapidly activated both ERK1/2 and p38MAPK , and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV induced COX-2 expression and 6-keto-PGF1alpha formation
Pan et al., Shock 2008 : Western blotting analysis showed that PAR2-AP induced phosphorylation of p38 MAPK and its upstream protein kinase MAPK kinase 3/6 ( MKK3/6 ) in a time dependent manner
Namkung et al., Am J Physiol Gastrointest Liver Physiol 2008 (Pancreatitis) : Effects of PAR2 activation on intrapancreatic damage and on mitogen activated protein ( MAP ) kinase signaling were assessed
Shi et al., Zhonghua Zhong Liu Za Zhi 2009 (Colonic Neoplasms) : Factor VIIa and PAR2-AP induced IL-8 expression at both mRNA and protein levels, upregulated TF mRNA expression and TF activity, but down-regulated caspase-7 mRNA and p-p38 MAPK levels in SW620 cells
Flynn et al., J Biol Chem 2011 (Calcium Signaling...) : All peptidomimetic agonists stimulated PAR(2) dependent in vitro physiological responses, MAPK signaling, and Ca ( 2+ ) signaling with an overall rank order of potency of 2-f-LIGRLO-NH ( 2 ) ˜ 2-at-LIGRL-NH ( 2 ) > 6-an-LIGRL-NH ( 2 ) » SLIGRL-NH ( 2 )
Saito et al., Hum Reprod 2011 (Endometriosis...) : The TGF-ß1 induced increase in PAR2 gene expression was repressed by inhibition of p38 MAPK , p42/44 MAPK or PI3K, but not by knockdown of Smad4 expression
Ramachandran et al., J Biol Chem 2011 (Calcium Signaling...) : Interestingly, elastase ( but neither cathepsin-G nor proteinase-3 ) causes a TL-independent PAR(2) mediated activation of MAPK that, unlike the canonical trypsin activation, does not involve either receptor internalization or recruitment of ß-arrestin
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012 : Although PAR(2) activation increased ERK MAPK phosphorylation, neither ERK pathway inhibitors nor a p38 MAPK inhibitor affected 2fLI induced COX-2 expression
Zhang et al., Cell Physiol Biochem 2012 (MAP Kinase Signaling System) : Inhibition of PAR-2 suppressed tryptase induced ERK and p38 MAPK pathway activation in microglia