◀ Back to VEGFA
FLT1 — VEGFA
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of FLT1-VEGFA
→
THBS1
(increases)
Evidence: This was shown to increase the association of VEGF with its receptor VEGFR2 (REF. 50).
-
OpenBEL Selventa BEL large corpus:
KDR
→
Complex of FLT1-KDR-VEGFA
(decreases, FLT1/KDR/VEGFA Activity)
Evidence: VEGFR1 functions as a negative regulator of VEGFR2 a soluble form of the extracellular VEGFR1 domain occurs naturally, and overexpression of this form, but not of an artificial soluble VEGFR2, inhibits VEGF-induced migration and proliferation of HUVECs by forming an inactive complex with VEGF and the full-length VEGFR2
-
OpenBEL Selventa BEL large corpus:
FLT1
→
Complex of PGF-VEGFA
(increases, PGF/VEGFA Activity)
Evidence: VEGFR1 does appear to mediate VEGF- and PIGF-induced tissue factor expression and chemotaxis in monocytes, a cell type that expresses only VEGFR1
-
OpenBEL Selventa BEL large corpus:
Complex of FLT1-VEGFA
→
MMP9
(increases, FLT1/VEGFA Activity)
Evidence: a function of MMP9 is to render VEGF bioavailable to its receptors VEGF blockade inhibits bone repair
-
OpenBEL Selventa BEL large corpus:
Complex of FLT1-VEGFA
→
MMP9
(increases, FLT1/VEGFA Activity)
Evidence: The matrix metalloproteinase (MMP)-9 was also found to be a component of the angiogenic switch. By releasing sequestered VEGF, this proteinase makes VEGF available for interaction with its receptors45.
-
KEGG Focal adhesion:
EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD/PGF/VEGFA/VEGFB/VEGFC
→
EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB
(protein-protein, activation)
-
KEGG Rheumatoid arthritis:
PGF/VEGFA/VEGFB
→
FLT1
(protein-compound, activation)
-
KEGG Cytokine-cytokine receptor interaction:
VEGFA
→
FLT1
(protein-protein, activation)
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (FLT1)
→
VEGFA (dimer) complex (VEGFA)
(modification, collaborate)
Autiero et al., Nat Med 2003*, Tischer et al., J Biol Chem 1991*, Leung et al., Science 1989*, Cohen et al., J Biol Chem 1995*, Keyt et al., J Biol Chem 1996*, Cunningham et al., Biochem Biophys Res Commun 1997, Ito et al., J Biol Chem 1998
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (FLT1)
→
VEGFR1 (dimer)/VEGFA (dimer) complex (FLT1-VEGFA)
(modification, collaborate)
Autiero et al., Nat Med 2003*, Tischer et al., J Biol Chem 1991*, Leung et al., Science 1989*, Cohen et al., J Biol Chem 1995*, Keyt et al., J Biol Chem 1996*, Cunningham et al., Biochem Biophys Res Commun 1997, Ito et al., J Biol Chem 1998
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA (dimer) complex (VEGFA)
→
VEGFR1 (dimer)/VEGFA (dimer) complex (FLT1-VEGFA)
(modification, collaborate)
Autiero et al., Nat Med 2003*, Tischer et al., J Biol Chem 1991*, Leung et al., Science 1989*, Cohen et al., J Biol Chem 1995*, Keyt et al., J Biol Chem 1996*, Cunningham et al., Biochem Biophys Res Commun 1997, Ito et al., J Biol Chem 1998
Evidence: physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/VEGFA homodimer complex (FLT1-VEGFA)
→
NCK1 (NCK1)
(modification, collaborate)
Igarashi et al., Biochem Biophys Res Commun 1998, Ito et al., J Biol Chem 1998
Evidence: genetic interaction, physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/VEGFA homodimer complex (FLT1-VEGFA)
→
VEGFR1 homodimer/VEGFA homodimer/NCK1 complex (FLT1-VEGFA-NCK1)
(modification, collaborate)
Igarashi et al., Biochem Biophys Res Commun 1998, Ito et al., J Biol Chem 1998
Evidence: genetic interaction, physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
NCK1 (NCK1)
→
VEGFR1 homodimer/VEGFA homodimer/NCK1 complex (FLT1-VEGFA-NCK1)
(modification, collaborate)
Igarashi et al., Biochem Biophys Res Commun 1998, Ito et al., J Biol Chem 1998
Evidence: genetic interaction, physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
CD2AP (CD2AP)
→
VEGFR1 homodimer/VEGFA homodimer complex (FLT1-VEGFA)
(modification, collaborate)
Duval et al., J Biol Chem 2003, Kobayashi et al., FASEB J 2004*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database VEGFR1 specific signals:
CD2AP (CD2AP)
→
VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP complex (FLT1-VEGFA-CBL-CD2AP)
(modification, collaborate)
Duval et al., J Biol Chem 2003, Kobayashi et al., FASEB J 2004*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/VEGFA homodimer complex (FLT1-VEGFA)
→
CBL (CBL)
(modification, collaborate)
Duval et al., J Biol Chem 2003, Kobayashi et al., FASEB J 2004*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/VEGFA homodimer complex (FLT1-VEGFA)
→
VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP complex (FLT1-VEGFA-CBL-CD2AP)
(modification, collaborate)
Duval et al., J Biol Chem 2003, Kobayashi et al., FASEB J 2004*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database VEGFR1 specific signals:
CBL (CBL)
→
VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP complex (FLT1-VEGFA-CBL-CD2AP)
(modification, collaborate)
Duval et al., J Biol Chem 2003, Kobayashi et al., FASEB J 2004*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/NRP1/VEGFR 121 complex (FLT1-NRP1-VEGFA)
→
VEGFR1 homodimer/NRP1 complex (FLT1-NRP1)
(modification, collaborate)
Mamluk et al., J Biol Chem 2002
Evidence: physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/NRP1/VEGFR 121 complex (FLT1-NRP1-VEGFA)
→
VEGFA121 (VEGFA)
(modification, collaborate)
Mamluk et al., J Biol Chem 2002
Evidence: physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/NRP1 complex (FLT1-NRP1)
→
VEGFA121 (VEGFA)
(modification, collaborate)
Mamluk et al., J Biol Chem 2002
Evidence: physical interaction
-
NCI Pathway Database Glypican 1 network:
GPC1/VEGF165 homodimer/VEGFR1 homodimer complex (GPC1-FLT1-VEGFA)
→
VEGFR1 homodimer complex (FLT1)
(modification, collaborate)
Gengrinovitch et al., J Biol Chem 1999*
Evidence: assay, physical interaction
-
NCI Pathway Database Glypican 1 network:
GPC1/VEGF165 homodimer/VEGFR1 homodimer complex (GPC1-FLT1-VEGFA)
→
VEGF165 homodimer complex (VEGFA)
(modification, collaborate)
Gengrinovitch et al., J Biol Chem 1999*
Evidence: assay, physical interaction
-
NCI Pathway Database Glypican 1 network:
GPC1/VEGF165 homodimer/VEGFR1 homodimer complex (GPC1-FLT1-VEGFA)
→
GPC1 (GPC1)
(modification, collaborate)
Gengrinovitch et al., J Biol Chem 1999*
Evidence: assay, physical interaction
-
NCI Pathway Database Glypican 1 network:
VEGFR1 homodimer complex (FLT1)
→
VEGF165 homodimer complex (VEGFA)
(modification, collaborate)
Gengrinovitch et al., J Biol Chem 1999*
Evidence: assay, physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/VEGFA homodimer complex (FLT1-VEGFA)
→
Sck (SHC2) (SHC2)
(modification, collaborate)
Warner et al., Biochem J 2000*, Ratcliffe et al., Oncogene 2002*, Olsson et al., Nat Rev Mol Cell Biol 2006*, Igarashi et al., Biochem Biophys Res Commun 1998*
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/VEGFA homodimer complex (FLT1-VEGFA)
→
SHP2 (PTPN11)
(modification, collaborate)
Igarashi et al., Biochem Biophys Res Commun 1998, Ito et al., J Biol Chem 1998
Evidence: assay, physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/VEGFA homodimer complex (FLT1-VEGFA)
→
VEGFR1 homodimer/VEGFA homodimer/SHP2 complex (FLT1-VEGFA-PTPN11)
(modification, collaborate)
Igarashi et al., Biochem Biophys Res Commun 1998, Ito et al., J Biol Chem 1998
Evidence: assay, physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
SHP2 (PTPN11)
→
VEGFR1 homodimer/VEGFA homodimer/SHP2 complex (FLT1-VEGFA-PTPN11)
(modification, collaborate)
Igarashi et al., Biochem Biophys Res Commun 1998, Ito et al., J Biol Chem 1998
Evidence: assay, physical interaction
-
NCI Pathway Database S1P3 pathway:
VEGFR1 homodimer/VEGFA homodimer complex (FLT1-VEGFA)
→
S1P/S1P3/Gi complex (S1PR3-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(transcription, activates)
Fieber et al., Exp Cell Res 2006
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (FLT1)
→
VEGFR1 (dimer)/VEGFA206 (dimer) complex (FLT1-VEGFA)
(modification, collaborate)
Tischer et al., J Biol Chem 1991*, Houck et al., Mol Endocrinol 1991*, Sawano et al., Biochem Biophys Res Commun 1997*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (FLT1)
→
VEGFA206 (dimer) complex (VEGFA)
(modification, collaborate)
Tischer et al., J Biol Chem 1991*, Houck et al., Mol Endocrinol 1991*, Sawano et al., Biochem Biophys Res Commun 1997*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (dimer)/VEGFA206 (dimer) complex (FLT1-VEGFA)
→
VEGFA206 (dimer) complex (VEGFA)
(modification, collaborate)
Tischer et al., J Biol Chem 1991*, Houck et al., Mol Endocrinol 1991*, Sawano et al., Biochem Biophys Res Commun 1997*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (dimer)/VEGFA189 (dimer) complex (FLT1-VEGFA)
→
VEGFA189 (dimer) complex (VEGFA)
(modification, collaborate)
Tischer et al., J Biol Chem 1991*, Plouët et al., J Biol Chem 1997*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (dimer)/VEGFA189 (dimer) complex (FLT1-VEGFA)
→
VEGFR1 (FLT1)
(modification, collaborate)
Tischer et al., J Biol Chem 1991*, Plouët et al., J Biol Chem 1997*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA189 (dimer) complex (VEGFA)
→
VEGFR1 (FLT1)
(modification, collaborate)
Tischer et al., J Biol Chem 1991*, Plouët et al., J Biol Chem 1997*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1/2 (dimer)/VEGFA/PLGF1 complex (VEGFA-PGF-FLT1-KDR)
→
VEGFR1 (FLT1)
(modification, collaborate)
Autiero et al., Nat Med 2003*, DiSalvo et al., J Biol Chem 1995*, Cao et al., J Clin Invest 1996*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1/2 (dimer)/VEGFA/PLGF1 complex (VEGFA-PGF-FLT1-KDR)
→
VEGFA/PLGF1 complex (VEGFA-PGF)
(modification, collaborate)
Autiero et al., Nat Med 2003*, DiSalvo et al., J Biol Chem 1995*, Cao et al., J Clin Invest 1996*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1/2 (dimer)/VEGFA/PLGF1 complex (VEGFA-PGF-FLT1-KDR)
→
VEGFR2 (KDR)
(modification, collaborate)
Autiero et al., Nat Med 2003*, DiSalvo et al., J Biol Chem 1995*, Cao et al., J Clin Invest 1996*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (FLT1)
→
VEGFA/PLGF1 complex (VEGFA-PGF)
(modification, collaborate)
Autiero et al., Nat Med 2003*, DiSalvo et al., J Biol Chem 1995*, Cao et al., J Clin Invest 1996*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1/2 (dimer)/VEGFA (dimer) complex (VEGFA-FLT1-KDR)
→
VEGFR1 (FLT1)
(modification, collaborate)
Bernatchez et al., Br J Pharmacol 2001, Autiero et al., Nat Med 2003*, Gerhardt et al., J Cell Biol 2003, Neagoe et al., J Biol Chem 2005*, Matsumoto et al., EMBO J 2005*, Poltorak et al., J Biol Chem 1997*, Ito et al., J Biol Chem 1998
Evidence: assay, physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1/2 (dimer)/VEGFA (dimer) complex (VEGFA-FLT1-KDR)
→
VEGFA (dimer) complex (VEGFA)
(modification, collaborate)
Bernatchez et al., Br J Pharmacol 2001, Autiero et al., Nat Med 2003*, Gerhardt et al., J Cell Biol 2003, Neagoe et al., J Biol Chem 2005*, Matsumoto et al., EMBO J 2005*, Poltorak et al., J Biol Chem 1997*, Ito et al., J Biol Chem 1998
Evidence: assay, physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1/2 (dimer)/VEGFA (dimer) complex (VEGFA-FLT1-KDR)
→
VEGFR2 (KDR)
(modification, collaborate)
Bernatchez et al., Br J Pharmacol 2001, Autiero et al., Nat Med 2003*, Gerhardt et al., J Cell Biol 2003, Neagoe et al., J Biol Chem 2005*, Matsumoto et al., EMBO J 2005*, Poltorak et al., J Biol Chem 1997*, Ito et al., J Biol Chem 1998
Evidence: assay, physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (FLT1)
→
VEGFA (dimer) complex (VEGFA)
(modification, collaborate)
Bernatchez et al., Br J Pharmacol 2001, Autiero et al., Nat Med 2003*, Gerhardt et al., J Cell Biol 2003, Neagoe et al., J Biol Chem 2005*, Matsumoto et al., EMBO J 2005*, Poltorak et al., J Biol Chem 1997*, Ito et al., J Biol Chem 1998
Evidence: assay, physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA (dimer) complex (VEGFA)
→
VEGFR1 (dimer)/VEGFA (dimer)/NRP2 complex (FLT1-VEGFA-NRP2)
(modification, collaborate)
Gluzman-Poltorak et al., J Biol Chem 2001*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA (dimer) complex (VEGFA)
→
VEGFR1 (FLT1)
(modification, collaborate)
Gluzman-Poltorak et al., J Biol Chem 2001*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (dimer)/VEGFA (dimer)/NRP2 complex (FLT1-VEGFA-NRP2)
→
NRP2 (NRP2)
(modification, collaborate)
Gluzman-Poltorak et al., J Biol Chem 2001*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (dimer)/VEGFA (dimer)/NRP2 complex (FLT1-VEGFA-NRP2)
→
VEGFR1 (FLT1)
(modification, collaborate)
Gluzman-Poltorak et al., J Biol Chem 2001*
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VEGFR1/2 (dimer)/VEGFA (dimer) complex (VEGFA-FLT1-KDR)
→
PLCgamma1 (PLCG1)
(modification, activates)
Huang et al., Int J Biochem Cell Biol 2001*, Cunningham et al., Biochem Biophys Res Commun 1997
Evidence: assay, physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (dimer)/VEGFA (dimer)/NRP1 complex (FLT1-VEGFA-NRP1)
→
VEGFA (dimer) complex (VEGFA)
(modification, collaborate)
Fuh et al., J Biol Chem 2000*, Banerjee et al., Biochemistry 2008*, Kawamura et al., Blood 2008*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (dimer)/VEGFA (dimer)/NRP1 complex (FLT1-VEGFA-NRP1)
→
NRP1 (NRP1)
(modification, collaborate)
Fuh et al., J Biol Chem 2000*, Banerjee et al., Biochemistry 2008*, Kawamura et al., Blood 2008*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR1 (dimer)/VEGFA (dimer)/NRP1 complex (FLT1-VEGFA-NRP1)
→
VEGFR1 (FLT1)
(modification, collaborate)
Fuh et al., J Biol Chem 2000*, Banerjee et al., Biochemistry 2008*, Kawamura et al., Blood 2008*
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA (dimer) complex (VEGFA)
→
VEGFR1 (FLT1)
(modification, collaborate)
Fuh et al., J Biol Chem 2000*, Banerjee et al., Biochemistry 2008*, Kawamura et al., Blood 2008*
Evidence: physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/VEGFA homodimer complex (FLT1-VEGFA)
→
VEGFR1 homodimer complex (FLT1)
(modification, collaborate)
Keyt et al., J Biol Chem 1996*
Evidence: assay, physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/VEGFA homodimer complex (FLT1-VEGFA)
→
VEGFA (dimer) complex (VEGFA)
(modification, collaborate)
Keyt et al., J Biol Chem 1996*
Evidence: assay, physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer complex (FLT1)
→
VEGFA (dimer) complex (VEGFA)
(modification, collaborate)
Keyt et al., J Biol Chem 1996*
Evidence: assay, physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFA121 (VEGFA)
→
VEGFR1 homodimer/NRP2/VEGFR121 complex (FLT1-NRP2-VEGFA)
(modification, collaborate)
Mamluk et al., J Biol Chem 2002
Evidence: physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFA121 (VEGFA)
→
VEGFR1 homodimer/NRP2 complex (FLT1-NRP2)
(modification, collaborate)
Mamluk et al., J Biol Chem 2002
Evidence: physical interaction
-
NCI Pathway Database VEGFR1 specific signals:
VEGFR1 homodimer/NRP2/VEGFR121 complex (FLT1-NRP2-VEGFA)
→
VEGFR1 homodimer/NRP2 complex (FLT1-NRP2)
(modification, collaborate)
Mamluk et al., J Biol Chem 2002
Evidence: physical interaction
-
Reactome Reaction:
VEGFA
→
FLT1
(indirect_complex)
Takahashi et al., EMBO J 2001*, Autiero et al., Journal of thrombosis and haemostasis : JTH 2003*, Leung et al., Science 1989*, Olofsson et al., Proc Natl Acad Sci U S A 1996*, Muller et al., Proc Natl Acad Sci U S A 1997*, Ito et al., J Biol Chem 1998
-
Reactome Reaction:
VEGFA
→
FLT1
(reaction)
Takahashi et al., EMBO J 2001*, Autiero et al., Journal of thrombosis and haemostasis : JTH 2003*, Leung et al., Science 1989*, Olofsson et al., Proc Natl Acad Sci U S A 1996*, Muller et al., Proc Natl Acad Sci U S A 1997*, Ito et al., J Biol Chem 1998
-
WikiPathways Angiogenesis:
VEGFA
→
FLT1
(unknown)
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16
→
FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK
(activation)
-
WikiPathways Focal Adhesion:
EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PGF/PDGFC/PDGFD/VEGFA/VEGFB/VEGFC
→
BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
FLT1
—
VEGFA
Yamazaki et al., J Biol Chem 2003*
-
IRef Bind Interaction:
FLT1
—
VEGFA
Gerhardt et al., J Cell Biol 2003
-
IRef Bind Interaction:
FLT1
—
VEGFA
Starovasnik et al., J Mol Biol 1999*, Wiesmann et al., Cell 1997*
-
IRef Bind Interaction:
FLT1
—
VEGFA
Wiesmann et al., Cell 1997*
-
IRef Bind_translation Interaction:
FLT1
—
VEGFA
(surface plasmon resonance)
Yamazaki et al., J Biol Chem 2003*
-
IRef Bind_translation Interaction:
FLT1
—
VEGFA
(coimmunoprecipitation)
Gerhardt et al., J Cell Biol 2003
-
IRef Bind_translation Interaction:
FLT1
—
VEGFA
(x-ray crystallography)
Wiesmann et al., Cell 1997*
-
IRef Biogrid Interaction:
FLT1
—
VEGFA
(direct interaction, pull down)
Allain et al., Cell Signal 2012*
-
IRef Dip Interaction:
FLT1
—
VEGFA
(physical association, biochemical)
Keyt et al., J Biol Chem 1996*
-
IRef Hprd Interaction:
FLT1
—
VEGFA
(in vivo)
Ambati et al., Nature 2006*, Keyt et al., J Biol Chem 1996*, Wiesmann et al., Cell 1997*
-
IRef Hprd Interaction:
FLT1
—
VEGFA
(in vitro)
Ambati et al., Nature 2006*, Keyt et al., J Biol Chem 1996*, Wiesmann et al., Cell 1997*
-
IRef Intact Interaction:
FLT1
—
VEGFA
(direct interaction, x-ray crystallography)
Starovasnik et al., J Mol Biol 1999*
-
IRef Intact Interaction:
FLT1
—
VEGFA
(direct interaction, x-ray crystallography)
Wiesmann et al., Cell 1997*
-
IRef Ophid Interaction:
FLT1
—
VEGFA
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
FLT1
—
VEGFA
(aggregation, confirmational text mining)
Keyt et al., J Biol Chem 1996*
Text-mined interactions from Literome
Tufro et al., J Am Soc Nephrol 1999
:
In late fetal kidneys ( E19 ), immunoreactive
VEGF was
detected in glomerular epithelial and tubular cells, whereas
Flt-1 and Flk-1 were expressed in contiguous endothelial cells ...
VEGF induced upregulation of Flk-1 and
Flt-1 expression, as assessed by Western blot analysis
Aoki et al., Blood 1999
(Lymphoma, Non-Hodgkin) :
Two of the PEL cell lines expressed the VEGF/VPF receptor
Flt-1 , but
VEGF/VPF did not
stimulate proliferation in these cells
Warner et al., Biochem J 2000
:
It has also been difficult to demonstrate
VEGF induced phosphorylation of
Flt1 , which has led to speculation that KDR may be the more important receptor for the mitogenic action of VEGF on endothelial cells
Kroll et al., Z Kardiol 2000
(Cardiovascular Diseases) :
VEGF-A stimulates many actions of endothelial cells including proliferation, migration, and nitric oxide release via binding to and activation of the two primarily endothelial-specific receptor-tyrosine kinases KDR and
Flt-1
Sato et al., Ann N Y Acad Sci 2000
:
VEGF stimulated the expression of transcription factor Ets-1 as well as matrix metalloproteinase-1 (MMP-1) and
Flt-1 in HUVECs
Suzuma et al., J Biol Chem 2000
:
VEGF activated the tyrosine receptor phosphorylation of KDR and
Flt1 and increased the binding of phosphatidylinositol 3-kinase ( PI3-kinase ) p85 subunit to KDR and Flt1, both of which could mediate CTGF gene induction
Abbott et al., Dev Dyn 2000
:
VEGFR1 may be primarily
responsible for binding of
VEGF to yolk sac and embryonic tissues, as masking VEGFR2 did not reduce VEGF binding in those areas, and it is interesting that major structural defects were also not found in those regions
Aoki et al., Leukemia & lymphoma 2001
(Herpesviridae Infections...) :
Two of the PEL cell lines express the VEGF/VPF receptor
Flt-1 , but
VEGF did not
stimulate proliferation in these cells
Wulff et al., J Clin Endocrinol Metab 2001
:
Luteal
Flt mRNA expression is dependent upon VEGF, and
VEGF inhibition
results in abortive increases in expression of VEGF, angiopoietin-2, and Tie-2
Deroanne et al., Oncogene 2002
:
TSA inhibited in a dose dependent and reversible fashion the
VEGF induced expression of VEGF receptors,
VEGFR1 , VEGFR2, and neuropilin-1
Koolwijk et al., Angiogenesis 2001
:
Involvement of VEGFR-2 ( kdr/flk-1 ) but not
VEGFR-1 ( flt-1 ) in
VEGF-A and VEGF-C induced tube formation by human microvascular endothelial cells in fibrin matrices in vitro ... These data indicate that
VEGF-A or VEGF-C
activation of the VEGFR-2, and not of
VEGFR-1 , is involved in the formation of capillary-like tubular structures of hMVEC in 3D fibrin matrices used as a model of repair associated or pathological angiogenesis in vitro
Witmer et al., Invest Ophthalmol Vis Sci 2002
(Diabetic Retinopathy) :
Initial vascular
VEGF signaling may
act primarily through
VEGFR-1
Zhao et al., Circulation 2002
(Arteriosclerosis...) :
Soluble
FLT-1 can
suppress VEGF activity both by sequestering VEGF and by functioning as a dominant negative inhibitor of VEGF receptors
Bernatchez et al., J Cell Biochem 2002
:
In contrast,
stimulation of
PAEC-Flt-1 and PAEC-NRP-1 with
VEGF-A or VEGF-C did not induce proliferation, migration, or PAF synthesis
Hoshida et al., Pancreas 2002
(Neovascularization, Pathologic...) :
The soluble form of
flt-1 VEGF receptor
inhibits VEGF activity in a dominant negative manner
Itokawa et al., Mol Cancer Ther 2002
(Neovascularization, Pathologic) :
SU5416 inhibited cell migration of human vascular endothelial cells expressing both
Flt-1 and KDR in
response to
VEGF and also inhibited the cell migration in response to placenta growth factor ( PIGF ), a specific ligand for Flt-1
Zhang et al., Am J Reprod Immunol 2003
:
We found that up-regulation of the expression of MMPs was
induced by FN and
VEGF through the focal adhesion kinase ( FAK ) /mitogen activated protein kinase ( MAPK ) and
Flt-1/p38SAPK/MAPKAPK2 signaling pathways, respectively
Lissbrant et al., Prostate 2004
:
The testosterone stimulated increase in epithelial cell proliferation was unaffected by
flt ( 1-3 ) IgG, but endothelial and epithelial cell apoptosis were
increased in the
anti-VEGF compared to the vehicle treated groups
Kobayashi et al., FASEB J 2004
:
The c-Cbl/CD2AP complex regulates
VEGF induced endocytosis and degradation of
Flt-1 ( VEGFR-1 )
Takeda et al., Circ Res 2004
:
In conclusion, EPAS1 promotes
Flt-1 gene expression and
induces mRNA expression of
VEGF , Flk-1, and Tie2, leading to enhancement of mature angiogenesis in vivo
Huckle et al., J Cell Biochem 2004
:
Alternative Flt-1 RNA processing, involving retention of intron 13 and the use of intronic cleavage-polyadenylation signals, produces a secreted form of
Flt-1 , `` sFlt-1, '' that binds VEGF with high affinity and can
inhibit VEGF signaling
Chen et al., Biochem Biophys Res Commun 2005
:
In addition, 11,11'-dideoxyverticillin decreased VEGF secretion by MDA-MB-468 breast cancer cells, and significantly suppressed
VEGF induced tyrosine phosphorylation of
Flt-1 and KDR/Flk-1
Singh et al., Invest Ophthalmol Vis Sci 2005
(Anoxia...) :
Flt24K suppressed
VEGF expression by 30.8 % ( P = 0.042 ), leukocytes by 25.8 % ( P < 0.001 ), and neovascularization by 49.5 % ( P = 0.015 )
Wey et al., Cancer 2005
(Neoplasm Invasiveness...) :
VEGFR-1 stimulation by
VEGF-A or VEGF-B was found to promote migration in both cell lines
Aldridge et al., Biochem Biophys Res Commun 2005
(Bone Resorption) :
We have shown that
VEGF induces osteoclast differentiation through its action on
VEGFR1
Wang et al., Int J Cancer 2006
(Carcinoma...) :
Using real-time PCR, we found that
VEGF , at 20 ng/ml, significantly
increased the expression of
VEGFR-1 and VEGFR-2 by approximately 4-fold and 31-fold, respectively, compared to untreated control ( p < 0.05 )
Krysiak et al., Circ Res 2005
(Pre-Eclampsia) :
Soluble
vascular endothelial growth factor receptor-1 ( sFLT-1 )
mediates downregulation of
FLT-1 and prevents activated neutrophils from women with preeclampsia from additional migration by VEGF ...
VEGF dependent
FLT-1 expression is regulated by changing FLT-1-promoter activity
Cai et al., J Biol Chem 2006
(Neovascularization, Pathologic) :
PEDF was also able to inhibit
VEGF induced phosphorylation of
VEGFR-1
Kumai et al., J Cereb Blood Flow Metab 2007
(Brain Ischemia) :
Our goal in this study was to explore protective effects of gene transfer of soluble
flt-1 ( sFlt-1 ), a natural
inhibitor of
VEGF , on focal brain ischemia
Hirokoshi et al., Nephron. Clinical practice 2007
(Pre-Eclampsia) :
Here, we determined the ratio of serum concentration of soluble
fms-like tyrosine kinase 1 ( sFlt-1 ), a natural
inhibitor of pro-angiogenic
vascular endothelial growth factor ( VEGF ) relative to angiopoietin-2 (Ang-2), a natural antagonist of angiopoietin-1 (Ang-1) involved in promoting angiogenesis in the presence of VEGF, in women with preeclampsia
Lee et al., PLoS Med 2007
(Breast Neoplasms...) :
This study provides, to our knowledge for the first time, evidence of a unique survival system in breast cancer cells by which
VEGF can
act as an internal autocrine ( intracrine ) survival factor through its binding to
VEGFR1
Chandrasekaran et al., J Mol Graph Model 2007
:
In an attempt to identify the binding site for SPARC on VEGF, we hypothesized that this binding site could overlap at least partially the binding site of VEGF receptor 1 (VEGFR-1), as SPARC acts by preventing
VEGF induced phosphorylation of
VEGFR-1
Banerjee et al., Biochemistry 2008
(Breast Neoplasms) :
We found that
VEGF-A 165
induces hAOSMC migration parallel with the induction of NRP-1 and
VEGFR1 expressions and their associations along with the activation of PI3K/Akt
Jacobsen et al., J Bone Miner Res 2008
:
To test the hypothesis that DO is strictly dependent on vascualrization, we
inhibited vascular endothelial growth factor ( VEGF ) activity by antibody blockade of both receptors
VEGFR1 ( Flt-1 ) and VEGFR2 ( Flk-1 ) or only VEGFR2 ( Flk-1 ) in a previously developed murine tibia DO model
Krum et al., Exp Neurol 2008
(Brain Injuries...) :
VEGF signaling is
regulated mainly through its two primary receptors : flk-1 ( KDR/VEGF-R2 ) is expressed on vascular endothelium and some neurons and
flt-1 ( VEGF-R1 ) in the CNS, is expressed predominantly by activated astrocytes
Kimura et al., Cancer Sci 2008
(Colonic Neoplasms...) :
On the other hand, the three dihydroxystilbenes had no effect on VEGFR-1 and-2 expression, and
VEGF induced
VEGFR-1 phosphorylation in HUVECs
Rodewald et al., Hum Reprod 2009
(Ovarian Hyperstimulation Syndrome) :
The increased permeability in the presence of LGCs and hCG was inhibited when
VEGF was
blocked by
Flt-1Fc ( P < 0.05 )
Horta et al., J Mol Graph Model 2009
:
VEGF activates both
Flt-1 and KDR
Krejca et al., Med Sci Monit 2010
:
Outside stenting of the vein graft decreases
VEGF-A expression and
induces significant down-regulation of
VEGFR-1 in the intimal and medial layers after the re-endothelialization period ... These findings indicate that outside stenting of the vein graft decreases
VEGF-A expression and
induces significant down-regulation of
VEGFR-1 in the intima and media after the re-endothelialization
Genetos et al., Bone 2010
:
This suggests that
VEGF induction of Annexin A2 is not
mediated via VEGF-R1 agonism alone but by
VEGF-R1 and Neuropilin-1 or Neuropilin-2 heterodimers
Lee et al., Cancer Res 2010
(Carcinoma, Renal Cell...) :
VEGF induced greater phosphorylation of VEGFR-2 in lung ECs and of
VEGFR-1 in liver ECs
Ozgurtas et al., Hormone research in pædiatrics 2011
:
A soluble truncated form of
VEGFR-1 ( sVEGFR-1 ) binds to VEGF as strongly as full-length VEGFR-1 and
inhibits VEGF activity
Brave et al., Mol Cancer Ther 2011
:
Cediranib inhibited
VEGF-A stimulated
VEGFR-1 activation in AG1-G1-Flt1 cells ( IC ( 50 ) = 1.2 nmol/L ) ...
VEGF-A induced greatest phosphorylation of
VEGFR-1 at tyrosine residues Y1048 and Y1053 ; this was reversed by cediranib
Forsten-Williams et al., BMC systems biology 2011
:
VEGF also binds to extracellular matrix ( ECM ) and neuropilin ( NP ), a cell surface glycoprotein that
enhances VEGF binding to VEGFR2 while inhibiting
VEGF-VEGFR1 interactions
Cai et al., J Biol Chem 2011
(Neovascularization, Pathologic) :
We have reported previously that pigment epithelium derived factor (PEDF) can, via ?-secretase mediated events, inhibit VEGF induced angiogenesis in microvascular endothelial cells by both ( a ) cleavage and intracellular translocation of a C-terminal fragment of VEGF receptor-1 (VEGFR1) and ( b ) inhibition of
VEGF induced phosphorylation of
VEGFR1
Le Roux et al., J Am Soc Nephrol 2012
(Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis) :
Here, we observed a marked increase in serum levels of soluble
Flt1 ( sFlt1 ), a potent
inhibitor of
vascular endothelial growth factor , in patients with active ANCA associated vasculitis compared with patients during remission and other controls
Takahashi et al., Biol Pharm Bull 2011
(Neoplasms) :
VEGF-A activates
VEGFR-1 and VEGFR-2, whereas VEGF-B and PlGF bind to only VEFGR-1
Dellinger et al., PloS one 2011
:
In vitro experiments with primary human dermal lymphatic endothelial cells ( LECs ) demonstrate that blocking
VEGF-A activation of VEGFR2, not
VEGFR1 , significantly inhibits VEGF-A induced proliferation and migration of LECs
Avraham-Lubin et al., Stem Cell Rev 2012
(Disease Models, Animal...) :
VEGF signaling
mediated by
Flt-1 induces early neural and sustained astrocytic differentiation of stem cells elutriated from adult bone-marrow, with significant contribution to stabilization retinal architecture following ischemic injury
Woollard et al., Prostate 2013
(Lymphatic Metastasis...) :
These results suggest that
activation of
VEGFR-1 by
VEGF-A within the carcinoma, and activation of lymphatic endothelial cell VEGFR-3 by VEGF-D within the adjacent benign stroma may be important signaling mechanisms involved in the progression and subsequent metastatic spread of prostate cancer
Gennari-Moser et al., Hypertension 2013
(Pre-Eclampsia) :
In rats, overexpression of soluble
fms-like tyrosine kinase-1 , an endogenous
VEGF inhibitor , led to adrenocortical capillary rarefaction and fall in aldosterone concentrations that correlated inversely with soluble fms-like tyrosine kinase-1 levels
Zheng et al., J Ethnopharmacol 2013
:
tPNS ( 100µg/ml ) significantly
enhanced the mRNA expression level of
VEGF-A and Kdr compared to the control group, while they had no obvious effect on the expression of
Flt-1
Saito et al., FEBS Lett 2013
(MAP Kinase Signaling System) :
VEGF-A induces its negative regulator, soluble form of
VEGFR-1 , by modulating its alternative splicing
Sato et al., J Clin Invest 1995
(Graves Disease) :
VEGF , a secretable angiogenesis factor, subsequently
stimulates Flt receptors on endothelial cells in a paracrine manner, leading to their proliferation and producing hypervascularity of the thyroid gland, as seen in patients with Graves ' disease
Waltenberger et al., J Biol Chem 1994
:
KDR was found to undergo ligand induced autophosphorylation in intact cells, and both
Flt1 and KDR were phosphorylated in vitro in
response to
VEGF , however, KDR much more efficiently than Flt1
Pajusola et al., Oncogene 1994
:
Also,
FLT4 did not interact with KDR in
response to
VEGF
Lee et al., Proc Natl Acad Sci U S A 1996
:
Flt1 and Flk1 have been shown to play key roles in vascular development ; these two receptors bind and are
activated by
vascular endothelial growth factor ( VEGF )
Albini et al., Nat Med 1996
(Neovascularization, Pathologic) :
Endothelial cell stimulation by Tat occurs in the absence of
activation of
FLT-1 , another
VEGF-A tyrosine kinase receptor
Barleon et al., Cancer Res 1997
:
VEGF stimulated
FLT-1 mRNA expression was inhibited by actinomycin D
Landgren et al., Oncogene 1998
:
We furthermore examined induction of protein levels of plasminogen activator (PA), which was evident in the PlGF stimulated
Flt 1 cells, but not in the
VEGF stimulated KDR cells
Joukov et al., J Biol Chem 1998
:
VEGF activates the endothelial VEGF receptors
(VEGFR) 1 and 2, and VEGF-C activates VEGFR-3 and VEGFR-2
Oyama et al., J Immunol 1998
:
Thus, NF-kappa B plays an important role in maturation of HPCs to DC, and
VEGF activation of the
Flt-1 receptor is able to block the activation of NF-kappa B in this system