Liu et al., Mol Cell Biol 2001
:
Overexpression of Gab2 in FD-Fms cells enhanced both mitogen activated protein kinase ( MAPK ) activity and macrophage differentiation, but reduced proliferation, in response to M-CSF
Million et al., Mol Cell Biol 2004
(Cell Transformation, Neoplastic...) :
A Tel-Abl point mutant ( Y314F ) and a splice variant without TEL exon 5 sequences ( Deltae5 ) lacked Grb2 interaction and exhibited decreased binding and phosphorylation of the scaffolding protein Gab2 and impaired activation of phosphatidylinositol 3-kinase, Akt, and extracellular signal regulated kinase/mitogen activated protein kinase in hematopoietic cells
Zhang et al., Mol Cell Biol 2013
(Breast Neoplasms) :
We now demonstrate that activation of the Ras/mitogen activated protein kinase ( MAPK ) pathway promotes Gab2 phosphorylation on basic consensus motifs