Gene interactions and pathways from curated databases and text-mining

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GAST — MAPK6

Text-mined interactions from Literome

Dehez et al., FEBS Lett 2001 : We present evidence that gastrin , binding to a G protein coupled receptor, activates the p38-mitogen activated protein kinase ( MAPK ) pathway
Schmitz et al., Eur J Clin Invest 2001 (Colorectal Neoplasms) : Mutation 287V -- > F is associated with a loss of gastrin induced MAPK p44/p42 signalling in Colo 320 cells while clonal expansion from single cells is increased by 53.1 +/- 15.9 % when compared to Colo 320 cells expressing wild-type CCK-B/gastrin receptors
Tucker et al., Helicobacter 2010 (Disease Models, Animal...) : Activation of gastrin through MAPK signaling did not require CagA or VacA virulence factors
Todisco et al., J Biol Chem 1995 : In similar fashion, gastrin stimulated the activity of mitogen activated protein kinase , an enzyme known to mediate the induction of the c-fos serum response element in response to growth factor stimulation
Seva et al., Biochem Biophys Res Commun 1997 (Pancreatic Neoplasms) : In addition, blocking PI-3-kinase activity by wortmannin partially decreased gastrin induced MAPK activation ( 42 % +/- 3 ) as well as the tyrosine phosphorylation of She ( 50 % +/- 6 ), an upstream regulator of the Ras dependent MAPK pathway ... These results indicate that at least two signaling pathways lead to MAPK activation by gastrin , only one of which is sensitive to PI-3-kinase inhibitors