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EPHB2 — GATA4
Text-mined interactions from Literome
Fowkes et al., Biol Reprod 2002
:
Electrophoretic mobility shift assays for SF-1 and GATA revealed that PMA failed to affect SF-1 binding but enhanced GATA binding to a consensus GATA oligonucleotide, an effect that was blocked with U0126 pretreatment, suggesting that
GATA may
mediate ERK activation of alphaGSU transcription
Huang et al., Am J Physiol Heart Circ Physiol 2008
(Cardiomyopathy, Dilated...) :
Previous studies in neonatal cardiac myocytes indicated that the cardiac-specific transcription factor GATA4 is a downstream mediator of
alpha1-ERK signaling and that phosphorylation of
GATA4 by ERK
increases DNA binding and transcriptional activity
Liu et al., J Cell Sci 2009
:
Pharmacological inhibition of
ERK1/2 or p38 MAPK
blocked vitronectin induced
GATA4 nuclear translocation and endoderm maturation, whereas expression of a constitutively active ERK kinase ( MEK1 ) or p38 MAPK in the mutant cells rescued endoderm maturation in integrin-beta1-null endoderm cells
Ku et al., Cardiovascular diabetology 2011
(Cardiomegaly...) :
Hyperglycemia can cause systolic dysfunction and a higher expression of cTnI in cardiomyocytes through ROS, enhancing
MEK/ERK induced
GATA-4 phosphorylation and accumulation in the cell nucleus
Jun et al., J Cell Physiol 2013
:
Inhibition of
ERK activity by U0126,
suppressed EPO induced expression of
GATA-4 protein in rat cardiac myocytes ... In addition,
ERK activation by over-expression of constitutively active MEK1 strongly
increased GATA-4 phosphorylation and subsequently enhanced its acetylation in P19 cells ... EPO induced
ERK activation further
increased the association of
GATA-4 with p300 ... Taken together, these results indicated that EPO induced
ERK signaling activation
increased GATA-4 phosphorylation and acetylation, partly via increase in the association between GATA-4 and p300, and these processes required the phosphorylation of GATA-4 at Ser-261 residue
Jun et al., Biol Pharm Bull 2013
:
ERK activation by over-expression of constitutively active mitogen activated protein kinase 1 ( MEK1 ) strongly
increased GATA-4 phosphorylation and its protein levels and decreased GATA-4 ubiquitination under hypoxia