Gene interactions and pathways from curated databases and text-mining

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EPHB2 — GATA4

Text-mined interactions from Literome

Fowkes et al., Biol Reprod 2002 : Electrophoretic mobility shift assays for SF-1 and GATA revealed that PMA failed to affect SF-1 binding but enhanced GATA binding to a consensus GATA oligonucleotide, an effect that was blocked with U0126 pretreatment, suggesting that GATA may mediate ERK activation of alphaGSU transcription
Huang et al., Am J Physiol Heart Circ Physiol 2008 (Cardiomyopathy, Dilated...) : Previous studies in neonatal cardiac myocytes indicated that the cardiac-specific transcription factor GATA4 is a downstream mediator of alpha1-ERK signaling and that phosphorylation of GATA4 by ERK increases DNA binding and transcriptional activity
Liu et al., J Cell Sci 2009 : Pharmacological inhibition of ERK1/2 or p38 MAPK blocked vitronectin induced GATA4 nuclear translocation and endoderm maturation, whereas expression of a constitutively active ERK kinase ( MEK1 ) or p38 MAPK in the mutant cells rescued endoderm maturation in integrin-beta1-null endoderm cells
Ku et al., Cardiovascular diabetology 2011 (Cardiomegaly...) : Hyperglycemia can cause systolic dysfunction and a higher expression of cTnI in cardiomyocytes through ROS, enhancing MEK/ERK induced GATA-4 phosphorylation and accumulation in the cell nucleus
Jun et al., J Cell Physiol 2013 : Inhibition of ERK activity by U0126, suppressed EPO induced expression of GATA-4 protein in rat cardiac myocytes ... In addition, ERK activation by over-expression of constitutively active MEK1 strongly increased GATA-4 phosphorylation and subsequently enhanced its acetylation in P19 cells ... EPO induced ERK activation further increased the association of GATA-4 with p300 ... Taken together, these results indicated that EPO induced ERK signaling activation increased GATA-4 phosphorylation and acetylation, partly via increase in the association between GATA-4 and p300, and these processes required the phosphorylation of GATA-4 at Ser-261 residue
Jun et al., Biol Pharm Bull 2013 : ERK activation by over-expression of constitutively active mitogen activated protein kinase 1 ( MEK1 ) strongly increased GATA-4 phosphorylation and its protein levels and decreased GATA-4 ubiquitination under hypoxia