Gene interactions and pathways from curated databases and text-mining

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GLI1 — MAPK10

Text-mined interactions from Literome

Neill et al., Cancer Res 2003 (Carcinoma, Basal Cell...) : Furthermore, PKC regulation of Gli1 did not involve activation of mitogen activated protein kinase signaling
Seto et al., Mol Carcinog 2009 (Adenocarcinoma, Mucinous...) : Indeed, MAPK signaling increased the GLI transcriptional activity and induced the expression of hedgehog target genes in gastric cancer cells ... The inductive effect of activated KRAS and mitogen activated protein/extracellular signal regulated kinase kinase ( MEK) 1 was blocked by the suppressor of fused (SUFU), indicating that MAPK signaling regulates GLI activity via a SUFU independent process
Atkinson et al., J Neurochem 2009 : Selective inhibition of p38 MAPK significantly attenuated Shh dependent up-regulation of Gli-1 , inter-alpha trypsin inhibitor and thrombomodulin mRNA, however did not affect expression of insulin-like growth factor 2 or a novel Shh target, membrane associated guanylate kinase p55 subfamily member 6