Gene interactions and pathways from curated databases and text-mining

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GLO1 — TNF

Text-mined interactions from Literome

Van Herreweghe et al., Proc Natl Acad Sci U S A 2002 : Tumor necrosis factor induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal derived AGE ... Furthermore, we provide evidence that the TNF induced phosphorylation of glyoxalase I is not involved in detoxification of MG by means of the glyoxalase system, but that phosphorylated glyoxalase I is on the pathway leading to the formation of a specific MG-derived advanced glycation end product
de Hemptinne et al., Biochem J 2007 : We have previously shown that TNF ( tumour necrosis factor ) induces phosphorylation of GLO1 ( glyoxalase I ), which is required for cell death in L929 cells ... In the present paper, we show that the TNF induced phosphorylation of GLO1 occurs primarily on the NO ( nitric oxide ) -responsive form of GLO1 ... In summary, these data suggest that the TNF induced phosphorylation of GLO1 is the dominant factor for cell death
de Hemptinne et al., Mol Cell Biochem 2009 : By using this phospho-specific antibody, we demonstrated that TNF induces phosphorylation of GLO1 on Thr-106