Gene interactions and pathways from curated databases and text-mining

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GNRH1 — RELA

Text-mined interactions from Literome

Gründker et al., J Clin Endocrinol Metab 2000 (Cystadenocarcinoma, Serous...) : We conclude that LHRH induces activation of NFkappaB and thus reduces Doxorubicin induced apoptosis in human ovarian cancer cells
Gründker et al., Eur J Endocrinol 2001 (Endometrial Neoplasms) : In addition, LHRH activates nucleus factor kappaB (NFkappaB) and protects the cancer cells from apoptosis
Günthert et al., Biochem Biophys Res Commun 2002 (Adenocarcinoma...) : Since LHRH activates nucleus factor kappa B (NF kappa B) and protects ovarian cancer cells from doxorubicin induced apoptosis and JunD is shown to decrease cell cycle and cell proliferation, we propose that JunD activated by LHRH acts as a modulator of cell proliferation and cooperates with the anti-apoptotic and anti-mitogenic functions of LHRH
Gründker et al., Reproductive biology and endocrinology : RB&E 2003 (Ovarian Neoplasms) : In addition GnRH activates nucleus factor kappaB (NFkappaB) and protects the cancer cells from apoptosis
Naidich et al., Endocrinology 2010 : Indeed, GnRH stimulates p65/RelA phosphorylation ( 22-fold ) in LbetaT2 cells and the two nuclear factor-kappaB sites apparently act as a composite response element