Gene interactions and pathways from curated databases and text-mining

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GPR115 — TNF

Text-mined interactions from Literome

Pascual et al., Am J Physiol Lung Cell Mol Physiol 2001 (MAP Kinase Signaling System) : In this study, we examined the mechanisms by which IL-1 beta and TNF-alpha affect inhibition of cell growth, G protein coupled receptor ( GPCR ) desensitization, and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures
Chen et al., J Appl Physiol 2003 : We previously reported that TNF-alpha , a cytokine involved in asthma, augments G-protein coupled receptor ( GPCR ) agonist evoked calcium responses in cultured ASM cells
Suo et al., J Neurosci 2004 (Alzheimer Disease...) : We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above, Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release, and at subthreshold doses, Abeta indirectly potentiated TNF-alpha release induced by certain G-protein coupled receptor ( GPCR ) activators