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GRB10 — MAPK12

Pathways - manually collected, often from reviews:

• WikiPathways Insulin Signaling: RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10 → MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14 (activation)
  

Text-mined interactions from Literome

Guilloton et al., Cell Signal 2007 (Leukemia, Myeloid, Acute) : The effects of TNFalpha and FasL on GrB expression were specifically mediated by p38MAPK ( Mitogen-activated-protein-kinase ) activation
Wang et al., Mol Cell Biol 2007 (Body Weight) : Loss of Grb10 expression in insulin target tissues, such as skeletal muscle and fat, resulted in enhanced insulin stimulated Akt and mitogen activated protein kinase phosphorylation
Nantel et al., J Biol Chem 1998 : Interaction of Grb10 with Raf1 is constitutive, while interaction between Grb10 and MEK1 needs insulin treatment of the cells and follows mitogen activated protein kinase activation