Gene interactions and pathways from curated databases and text-mining

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GRB2 — MAPK6

Pathways - manually collected, often from reviews:

  • WikiPathways Insulin Signaling: RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10 → MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14 (activation)

Text-mined interactions from Literome

Uchida et al., Mol Cell Biol 2000 : Insulin promoted the association of Grb-2 with IRS-1 and IRS-4, whereas IRS-2 weakly bound Grb-2 ; consequently, IRS-1 and IRS-4 enhanced insulin stimulated mitogen activated protein kinase activity
Zhou et al., J Immunol 2000 : In contrast, the phosphorylation of LAT and enhanced association with Grb2 led to activation of extracellular signal regulated kinase ( ERK ) mitogen activated protein kinase
Wang et al., Oncogene 2000 (Bone Neoplasms...) : The specific effect of LAR on FGF induced MAPK activation appeared to be mediated by specific inhibition of the phosphorylation of two signal transducers that act downstream of the FGF receptor, FRS2 and a 180 kDa protein, and by prevention of their interaction with the adaptor protein GRB2
Weng et al., Hum Mol Genet 2001 (Breast Neoplasms) : PTEN inhibits insulin stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
Leshem et al., Exp Cell Res 2002 (MAP Kinase Signaling System) : Whereas enhanced Grb2 binding increased the phosphorylation of the mitogen activated protein kinase/extracellular signal regulated protein kinases ( MAPK/ERK ) and abrogated that of p38 MAPK, PI3K had the opposite effect
Guilloton et al., Cell Signal 2007 (Leukemia, Myeloid, Acute) : The effects of TNFalpha and FasL on GrB expression were specifically mediated by p38MAPK ( Mitogen-activated-protein-kinase ) activation
Smith et al., EMBO J 2010 : The ShcA adaptor contains two phosphotyrosine recognition modules responsible for binding activated receptors, resulting in the subsequent recruitment of Grb2 and activation of Ras/MAPK
Maru et al., J Cell Physiol 1998 : Matrigel induced long lasting tyrosine phosphorylation of Shc, with recruitment of Grb-2 and microtubule associated protein kinase ( MAPK ) activation in both parental NP31 and NP31 transformed by ts-v-Ras, which was blocked by anti-beta1 integrin antibody